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Dimethyl phthalate


  • Brand : BIOFRON

  • Catalogue Number : BN-O1294

  • Specification : 98%(HPLC)

  • CAS number : 131-11-3

  • Formula : C10H10O4

  • Molecular Weight : 194.18

  • PUBCHEM ID : 8554

  • Volume : 0.1ml

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Catalogue Number


Analysis Method





Molecular Weight




Botanical Source

This product is isolated and purified from the herbs of Toona ciliata

Structure Type





phthalic acid dimethyl ester/Phthalic acid methyl ester/1,2-Benzenedicarboxylic acid, dimethyl ester/dimethyl 4-phthalate/Dimethyl phthalate acid ester/dimethyl 1,2-benzendicarboxylate/Benzene-1,2-dicarboxylic acid dimethyl ester/Dimethyl phthalate/Dimethyl phthalate soution/1,2-dimethyl 1,2-benzenedicarboxylate/Dimethyl benzeneorthodicarboxylate/dimethyl 1,2-benzenedicarboxylate/Dimethyl phthalate (DMP)/1,2-Benzenedicarboxylic acid dimethyl ester/dimethyl benzene-1,2-dicarboxylate/dimethyl o-phthalate/DIMETHYL P-PHTHALATE



1.2±0.1 g/cm3


Flash Point

146.1±0.0 °C

Boiling Point

282.7±8.0 °C at 760 mmHg

Melting Point

2 °C(lit.)


InChl Key


WGK Germany


HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:131-11-3) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.




Dimethyl phthalate (DMP) is a ubiquitous pollutant that is very harmful to organisms due to its mutagenicity, teratogenicity and carcinogenicity. Pseudomonas fluorescens (P. fluorescens) is one of the most important bacteria in the environment. In this study, the response of P. fluorescens to DMP was investigated. It was found that DMP greatly inhibited the growth and glucose utilization of P. fluorescens when the concentration of DMP was ranged from 20 to 40 mg/l. The surface hydrophobicity and membrane permeability of P. fluorescens were also increased by DMP. DMP could lead to the deformations of cell membrane and the mis-opening of membrane channels. RNA-Seq and RT-qPCR results showed that the expression of some genes in P. fluorescens were altered, including the genes involved in energy metabolism, ATP-binding cassette (ABC) transporting and two-component systems. Additionally, the productions of lactic acid and pyruvic acid were reduced and the activity of hexokinase was inhibited in P. fluorescens by DMP. Clearly, the results suggested that DMP contamination could alter the biological function of P. fluorescens in the environment.

Copyright © 2018 Elsevier Inc. All rights reserved.


ATP-binding cassette; Membrane damage; Phthalic acid esters; RNA-Seq; Two-component systems


Response of Pseudomonas fluorescens to dimethyl phthalate.


Wang Z1, Wang C2, You Y3, Xu W4, Lv Z5, Liu Z6, Chen W7, Shi Y8, Wang J9.

Publish date

2019 Jan 15




Phthalates are used in food packaging, and are transferred to foods as contaminants. In this study, we examined the hydrolytic metabolism of dimethyl phthalate (DMP), dibutyl phthalate (DBP) and di(2-ethylhexyl) phthalate (DEHP) by rat tissue microsomes. We found that carboxylesterase and lipase contribute differently to these activities. When DMP, DBP and DEHP were incubated with rat liver microsomes, DBP was most effectively hydrolyzed to the phthalate monoester, followed by DMP, and the activity toward DEHP was marginal. In contrast, small-intestinal microsomes exhibited relatively higher activity toward long-side-chain phthalates. Pancreatic microsomes showed high activity toward DEHP and DBP. Liver microsomal hydrolase activity toward DMP was markedly inhibited by bis(4-nitrophenyl)phosphate, and could be extracted with Triton X-100. The activity toward DBP and DEHP was partly inhibited by carboxylesterase inhibitor, and was partly solubilized with Triton X-100. Ces1e, Ces1d and Ces1f expressed in COS cells exhibited the highest hydrolase activity toward DBP, showing a similar pattern to that of liver microsomes. Ces1e showed activity towards DMP and DEHP. Pancreatic lipase also hydrolyzed DBP and DEHP. Thus, carboxylesterase and lipase contribute differently to phthalate hydrolysis: short-side-chain phthalates are mainly hydrolyzed by carboxylesterase and long-side-chain phthalates are mainly hydrolyzed by lipase.

Copyright © 2016 Elsevier Ltd. All rights reserved.


Carboxylesterase; Hydrolytic metabolism; Phthalate; Rat liver microsomes; Rat small-intestinal microsomes; Substrate specificity


Comparative study of hydrolytic metabolism of dimethyl phthalate, dibutyl phthalate and di(2-ethylhexyl) phthalate by microsomes of various rat tissues.


Ozaki H1, Sugihara K2, Watanabe Y3, Moriguchi K3, Uramaru N3, Sone T4, Ohta S1, Kitamura S5.

Publish date

2017 Feb




The aerobic biodegradation of dimethyl phthalate (DMP) is initiated with two hydrolysis reactions that generate an intermediate, phthalic acid (PA), that is further biodegraded through a two-step di-oxygenation reaction. DMP biodegradation is inhibited when PA accumulates, but DMP’s biodegradation can be enhanced by adding an exogenous electron donor. We evaluated the effect of adding succinate, acetate, or formate as an exogenous electron donor. PA removal rates were increased by 15 and 30% for initial PA concentrations of 0.3 and 0.6 mM when 0.15 and 0.30 mM succinate, respectively, were added as exogenous electron donor. The same electron-equivalent additions of acetate and formate had the same acceleration impacts on PA removal. Consequently, the DMP-removal rate, even PA coexisting with DMP simultaneously, was accelerated by 37% by simultaneous addition of 0.3 mM succinate. Thus, lowering the accumulation of PA by addition of an electron increased the rate of DMP biodegradation.


Di-oxygenation; Dimethyl phthalate; Electron donors; Phthalic acid


Enhanced dimethyl phthalate biodegradation by accelerating phthalic acid di-oxygenation.


Tang Y1, Zhang Y2, Jiang L1, Yang C1, Rittmann BE3.

Publish date

2017 Dec

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