Sodium (dichloromethylene)bis[hydrogen (phosphonate)] hydrate (2:1:4)/Phosphonic acid, (dichloromethylene)bis-, sodium salt, hydrate (1:2:4)/Disodium clodronate tetrahydrate/clodronate disodium tetrahydrate/Clodronate Disodium
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provides coniferyl ferulate(CAS#:88416-50-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate
31P CP/MAS NMR is used to characterize stability and changes in solid state properties of disodium clodronate tetrahydrate upon variable temperature and slow dehydration.
Variable temperature 31P CP/MAS NMR spectroscopy.
A fast rise in temperature leads to loss of lattice waters and produces an averaged structure characterized by a single 31P NMR resonance at 398 K. Slow room temperature dehydration converts the crystalline form to an anhydrous structure with two non-equivalent phosphorus atoms. The molecular skeleton of clodronate is stable within the temperature range 296 K-398 K of experiments. Rehydration of the anhydrous samples at room temperature restores the crystalline tetrahydrate form verified by a 31P CP/MAS NMR spectrum similar to that of a virginal sample.
Solid state NMR is a method which can offer both molecular and crystal scale information, when either bulk or dosage forms of a drug can be altered by temperature or by loss of lattice waters or solvents. The experiments are easy to perform, though time consuming, especially when low abundant nuclei are examined.
A 31P CP/MAS NMR study on dehydration of disodium clodronate tetrahydrate.
Timonen JT1, Pohjala E, Nikander H, Pakkanen TT.