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Disodium clodronate tetrahydrate

$928

  • Brand : BIOFRON

  • Catalogue Number : BN-O1364

  • Specification : 98%(HPLC)

  • CAS number : 88416-50-6

  • Formula : CH10Cl2Na2O10P2

  • Molecular Weight : 360.91

  • PUBCHEM ID : 23724874

  • Volume : 20mg

In stock

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Catalogue Number

BN-O1364

Analysis Method

Specification

98%(HPLC)

Storage

2-8°C

Molecular Weight

360.91

Appearance

Botanical Source

Structure Type

Category

SMILES

C(P(=O)(O)[O-])(P(=O)(O)[O-])(Cl)Cl.O.O.O.O.[Na+].[Na+]

Synonyms

Sodium (dichloromethylene)bis[hydrogen (phosphonate)] hydrate (2:1:4)/Phosphonic acid, (dichloromethylene)bis-, sodium salt, hydrate (1:2:4)/Disodium clodronate tetrahydrate/clodronate disodium tetrahydrate/Clodronate Disodium

IUPAC Name

disodium;[dichloro-[hydroxy(oxido)phosphoryl]methyl]-hydroxyphosphinate;tetrahydrate

Applications

Density

Solubility

Flash Point

Boiling Point

Melting Point

InChl

InChl Key

XWHPUCFOTRBMGS-UHFFFAOYSA-L

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:88416-50-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

9487556

Abstract

PURPOSE:
31P CP/MAS NMR is used to characterize stability and changes in solid state properties of disodium clodronate tetrahydrate upon variable temperature and slow dehydration.

METHODS:
Variable temperature 31P CP/MAS NMR spectroscopy.

RESULTS:
A fast rise in temperature leads to loss of lattice waters and produces an averaged structure characterized by a single 31P NMR resonance at 398 K. Slow room temperature dehydration converts the crystalline form to an anhydrous structure with two non-equivalent phosphorus atoms. The molecular skeleton of clodronate is stable within the temperature range 296 K-398 K of experiments. Rehydration of the anhydrous samples at room temperature restores the crystalline tetrahydrate form verified by a 31P CP/MAS NMR spectrum similar to that of a virginal sample.

CONCLUSIONS:
Solid state NMR is a method which can offer both molecular and crystal scale information, when either bulk or dosage forms of a drug can be altered by temperature or by loss of lattice waters or solvents. The experiments are easy to perform, though time consuming, especially when low abundant nuclei are examined.

Title

A 31P CP/MAS NMR study on dehydration of disodium clodronate tetrahydrate.

Author

Timonen JT1, Pohjala E, Nikander H, Pakkanen TT.

Publish date

1998 Jan