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DL-2-Amino-n-octanoic acid

$53

  • Brand : BIOFRON

  • Catalogue Number : BN-O1192

  • Specification : 98%(HPLC)

  • CAS number : 644-90-6

  • Formula : C8H17NO2

  • Molecular Weight : 159.23

  • PUBCHEM ID : 69522

  • Volume : 5mg

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Catalogue Number

BN-O1192

Analysis Method

Specification

98%(HPLC)

Storage

2-8°C

Molecular Weight

159.23

Appearance

Botanical Source

Structure Type

Category

SMILES

CCCCCCC(C(=O)O)N

Synonyms

(2S)-2-Ammoniooctanoate/1-Heptanaminium, 1-carboxy-, inner salt, (1S)-/DL-2-AMINOOCTANOIC ACID/H-ACPL(2)-OH/2-Aminoctanoic acid/aminooctanoic acid/2-AMINOCAPRYLIC ACID/aminocaprylic acid/H-AOC(2)-OH/(+/-)-octanoicaci/2-amino-octanoic acid/DL-Capryline

IUPAC Name

2-aminooctanoic acid

Density

0.999 g/cm3

Solubility

Methanol; Ethyl Acetate

Flash Point

115.8±22.6 °C

Boiling Point

267.8±23.0 °C at 760 mmHg

Melting Point

260 °C (dec.)(lit.)

InChl

InChl Key

AKVBCGQVQXPRLD-UHFFFAOYSA-N

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:644-90-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

21575829

Title

Does early school entry prevent obesity among adolescent girls?

Author

NING ZHANG, PhD1 and QI ZHANG, PhD2

Publish date

2012 Jun 1.

PMID

29881816

Abstract

Rodent and cell‐culture models support a role for iron‐related adipokine dysregulation and insulin resistance in the pathogenesis of nonalcoholic fatty liver disease (NAFLD); however, substantial human data are lacking. We examined the relationship between measures of iron status, adipokines, and insulin resistance in patients with NAFLD in the presence and absence of venesection. This study forms part of the Impact of Iron on Insulin Resistance and Liver Histology in Nonalcoholic Steatohepatitis (IIRON2) study, a prospective randomized controlled trial of venesection for adults with NAFLD. Paired serum samples at baseline and 6 months (end of treatment) in controls (n = 28) and patients who had venesection (n = 23) were assayed for adiponectin, leptin, resistin, retinol binding protein‐4, tumor necrosis factor α, and interleukin‐6, using a Quantibody, customized, multiplexed enzyme‐linked immunosorbent assay array. Hepatic iron concentration (HIC) was determined using MR FerriScan. Unexpectedly, analysis revealed a significant positive correlation between baseline serum adiponectin concentration and HIC, which strengthened after correction for age, sex, and body mass index (rho = 0.36; P = 0.007). In addition, there were significant inverse correlations between HIC and measures of insulin resistance (adipose tissue insulin resistance (Adipo‐IR), serum insulin, serum glucose, homeostasis model assessment of insulin resistance, hemoglobin A1c, and hepatic steatosis), whereas a positive correlation was noted with the insulin sensitivity index. Changes in serum adipokines over 6 months did not differ between the control and venesection groups. Conclusion: HIC positively correlates with serum adiponectin and insulin sensitivity in patients with NAFLD. Further study is required to establish causality and mechanistic explanations for these associations and their relevance in the pathogenesis of insulin resistance and NAFLD. (Hepatology Communications 2018;2:644‐653)

Title

Hepatic iron concentration correlates with insulin sensitivity in nonalcoholic fatty liver disease

Author

Laurence Britton,corresponding author 1 , 2 , 3 , 4 Kim Bridle, 1 , 2 Janske Reiling, 1 , 2 , 5 Nishreen Santrampurwala, 1 , 2 , 4 Leesa Wockner, 4 Helena Ching, 6 Katherine Stuart, 1 , 3 V. Nathan Subramaniam, 4 , 7 Gary Jeffrey, 6 , 8 Tim St. Pierre, 9 Michael House, 9 Joel Gummer, 10 Robert Trengove, 10 John Olynyk, 11 , 12 Darrell Crawford, 1 , 2 and Leon Adams 6 , 8

Publish date

2018 Jun

PMID

23447581

Abstract

The potent inflammatory mediator prostaglandin E2 (PGE2) is implicated in the pathogenesis of several chronic inflammatory conditions, including periodontitis. The inducible enzyme microsomal prostaglandin E synthase-1 (mPGES-1), catalyzing the terminal step of PGE2 biosynthesis, is an attractive target for selective PGE2 inhibition. To identify mPGES-1 inhibitors, we investigated the effect of aminothiazoles on inflammation-induced PGE2 synthesis in vitro, using human gingival fibroblasts stimulated with the cytokine IL-1β and a cell-free mPGES-1 activity assay, as well as on inflammation-induced bone resorption in vivo, using ligature-induced experimental periodontitis in Sprague-Dawley rats. Aminothiazoles 4-([4-(2-naphthyl)-1,3-thiazol-2-yl]amino)phenol (TH-848) and 4-(3-fluoro-4-methoxyphenyl)-N-(4-phenoxyphenyl)-1,3-thiazol-2-amine (TH-644) reduced IL-1β-induced PGE2 production in fibroblasts (IC50 1.1 and 1.5 μM, respectively) as well as recombinant mPGES-1 activity, without affecting activity or expression of the upstream enzyme cyclooxygenase-2. In ligature-induced experimental periodontitis, alveolar bone loss, assessed by X-ray imaging, was reduced by 46% by local treatment with TH-848, compared to vehicle, without any systemic effects on PGE2, 6-keto PGF1α, LTB4 or cytokine levels. In summary, these results demonstrate that the aminothiazoles represent novel mPGES-1 inhibitors for inhibition of PGE2 production and reduction of bone resorption in experimental periodontitis, and may be used as potential anti-inflammatory drugs for treatment of chronic inflammatory diseases, including periodontitis.—Kats, A., Bage, T., Georgsson, P., Jonsson, J., Quezada, H. C., Gustafsson, A., Jansson, L., Lindberg, C., Nasstrom, K., Yucel-Lindberg, T. Inhibition of microsomal prostaglandin E synthase-1 by aminothiazoles decreases prostaglandin E2 synthesis in vitro and ameliorates experimental periodontitis in vivo.

KEYWORDS

cyclooxygenase-2, gingival fibroblasts, interleukin-1β, PGE2, mPGES-1 inhibitor, anti-inflammatory

Title

Inhibition of microsomal prostaglandin E synthase-1 by aminothiazoles decreases prostaglandin E2 synthesis in vitro and ameliorates experimental periodontitis in vivo

Author

Anna Kats,*† Tove Bage,*† Pierre Georgsson,*† Jorgen Jonsson,* Hernan Concha Quezada,§ Anders Gustafsson,* Leif Jansson,‖ Claes Lindberg,¶ Karin Nasstrom,‡ and Tulay Yucel-Lindberg*†,1

Publish date

2013 Jun


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