(2S)-2-Ammoniooctanoate/1-Heptanaminium, 1-carboxy-, inner salt, (1S)-/DL-2-AMINOOCTANOIC ACID/H-ACPL(2)-OH/2-Aminoctanoic acid/aminooctanoic acid/2-AMINOCAPRYLIC ACID/aminocaprylic acid/H-AOC(2)-OH/(+/-)-octanoicaci/2-amino-octanoic acid/DL-Capryline
Methanol; Ethyl Acetate
267.8±23.0 °C at 760 mmHg
260 °C (dec.)(lit.)
HS Code Reference
Personal Projective Equipment
For Reference Standard and R&D, Not for Human Use Directly.
provides coniferyl ferulate(CAS#:644-90-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate
Does early school entry prevent obesity among adolescent girls?
NING ZHANG, PhD1 and QI ZHANG, PhD2
2012 Jun 1.
Rodent and cell‐culture models support a role for iron‐related adipokine dysregulation and insulin resistance in the pathogenesis of nonalcoholic fatty liver disease (NAFLD); however, substantial human data are lacking. We examined the relationship between measures of iron status, adipokines, and insulin resistance in patients with NAFLD in the presence and absence of venesection. This study forms part of the Impact of Iron on Insulin Resistance and Liver Histology in Nonalcoholic Steatohepatitis (IIRON2) study, a prospective randomized controlled trial of venesection for adults with NAFLD. Paired serum samples at baseline and 6 months (end of treatment) in controls (n = 28) and patients who had venesection (n = 23) were assayed for adiponectin, leptin, resistin, retinol binding protein‐4, tumor necrosis factor α, and interleukin‐6, using a Quantibody, customized, multiplexed enzyme‐linked immunosorbent assay array. Hepatic iron concentration (HIC) was determined using MR FerriScan. Unexpectedly, analysis revealed a significant positive correlation between baseline serum adiponectin concentration and HIC, which strengthened after correction for age, sex, and body mass index (rho = 0.36; P = 0.007). In addition, there were significant inverse correlations between HIC and measures of insulin resistance (adipose tissue insulin resistance (Adipo‐IR), serum insulin, serum glucose, homeostasis model assessment of insulin resistance, hemoglobin A1c, and hepatic steatosis), whereas a positive correlation was noted with the insulin sensitivity index. Changes in serum adipokines over 6 months did not differ between the control and venesection groups. Conclusion: HIC positively correlates with serum adiponectin and insulin sensitivity in patients with NAFLD. Further study is required to establish causality and mechanistic explanations for these associations and their relevance in the pathogenesis of insulin resistance and NAFLD. (Hepatology Communications 2018;2:644‐653)
Hepatic iron concentration correlates with insulin sensitivity in nonalcoholic fatty liver disease
Laurence Britton,corresponding author 1 , 2 , 3 , 4 Kim Bridle, 1 , 2 Janske Reiling, 1 , 2 , 5 Nishreen Santrampurwala, 1 , 2 , 4 Leesa Wockner, 4 Helena Ching, 6 Katherine Stuart, 1 , 3 V. Nathan Subramaniam, 4 , 7 Gary Jeffrey, 6 , 8 Tim St. Pierre, 9 Michael House, 9 Joel Gummer, 10 Robert Trengove, 10 John Olynyk, 11 , 12 Darrell Crawford, 1 , 2 and Leon Adams 6 , 8
The potent inflammatory mediator prostaglandin E2 (PGE2) is implicated in the pathogenesis of several chronic inflammatory conditions, including periodontitis. The inducible enzyme microsomal prostaglandin E synthase-1 (mPGES-1), catalyzing the terminal step of PGE2 biosynthesis, is an attractive target for selective PGE2 inhibition. To identify mPGES-1 inhibitors, we investigated the effect of aminothiazoles on inflammation-induced PGE2 synthesis in vitro, using human gingival fibroblasts stimulated with the cytokine IL-1β and a cell-free mPGES-1 activity assay, as well as on inflammation-induced bone resorption in vivo, using ligature-induced experimental periodontitis in Sprague-Dawley rats. Aminothiazoles 4-([4-(2-naphthyl)-1,3-thiazol-2-yl]amino)phenol (TH-848) and 4-(3-fluoro-4-methoxyphenyl)-N-(4-phenoxyphenyl)-1,3-thiazol-2-amine (TH-644) reduced IL-1β-induced PGE2 production in fibroblasts (IC50 1.1 and 1.5 μM, respectively) as well as recombinant mPGES-1 activity, without affecting activity or expression of the upstream enzyme cyclooxygenase-2. In ligature-induced experimental periodontitis, alveolar bone loss, assessed by X-ray imaging, was reduced by 46% by local treatment with TH-848, compared to vehicle, without any systemic effects on PGE2, 6-keto PGF1α, LTB4 or cytokine levels. In summary, these results demonstrate that the aminothiazoles represent novel mPGES-1 inhibitors for inhibition of PGE2 production and reduction of bone resorption in experimental periodontitis, and may be used as potential anti-inflammatory drugs for treatment of chronic inflammatory diseases, including periodontitis.—Kats, A., Bage, T., Georgsson, P., Jonsson, J., Quezada, H. C., Gustafsson, A., Jansson, L., Lindberg, C., Nasstrom, K., Yucel-Lindberg, T. Inhibition of microsomal prostaglandin E synthase-1 by aminothiazoles decreases prostaglandin E2 synthesis in vitro and ameliorates experimental periodontitis in vivo.
cyclooxygenase-2, gingival fibroblasts, interleukin-1β, PGE2, mPGES-1 inhibitor, anti-inflammatory
Inhibition of microsomal prostaglandin E synthase-1 by aminothiazoles decreases prostaglandin E2 synthesis in vitro and ameliorates experimental periodontitis in vivo
Anna Kats,*† Tove Bage,*† Pierre Georgsson,*† Jorgen Jonsson,* Hernan Concha Quezada,§ Anders Gustafsson,* Leif Jansson,‖ Claes Lindberg,¶ Karin Nasstrom,‡ and Tulay Yucel-Lindberg*†,1