Mentha haplocalyx Briq./Present in large amts. in Mentha piperita (peppermint) oil, also in other Mentha spp., Artemisia spp., Glechoma hederacea and others
(1R,2S,5R)-(−)-Menthol/levo-menthol/(-)-(1R,3R,4S)-Menthol/(−)-menthol/(-)-trans-p-Methan-cis-3-ol/(1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol/Levomenthol/L-Menthol/(-)-(1R,2S,5R)-Menthol/(-)-MENTHYL ALCOHOL/(1R)-(-)-Menthol/(R)-(-)-Menthol/DL-Menthol/(1R,2S,5R)-5-methyl-2-propan-2-yl-cyclohexan-1-ol/[1R-(1a,2b,5a)]-5-Methyl-2-(1-methylethyl)cyclohexanol/(-)-p-Menthan-3-ol/Cyclohexanol, 5-methyl-2-(1-methylethyl)-, (1R,2S,5R)-/(-)-Menthol/Menthol, l-/Menthol/(1R,2S,5R)-(-)-Menthol
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
215.4±8.0 °C at 760 mmHg
HS Code Reference
Personal Projective Equipment
For Reference Standard and R&D, Not for Human Use Directly.
provides coniferyl ferulate(CAS#:1490-04-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate
To investigate the role of mammalian target of rapamycin (mTOR) activation in menthol-induced expression of airway inflammation- related factors in human bronchial epithelial cells and explore its mechanism.
Cultured human bronchial epithelial cells (BEAS-2B) were divided into normal control group, menthol group, rapamycin group, and menthol+rapamycin group with corresponding treatments. The cell viability was measured with CCK-8 method. The mRNA levels of transient receptor potential melastatin 8 (TRPM8), tumor necrosis factor (TNF)-α and interleukin (IL)-1β were detected by RT-PCR, and the protein expressions of phosphorylated mTOR (p-mTOR), TRPM8, TNF-α and IL-1β were determined using Western blotting. The intracellular Ca2+ fluorescence intensity was measured by flow cytometry.
Compared with the normal control cells, menthol- treated cells showed significantly increased TNF-α, IL-1β, and p-mTOR expression and elevated intracellular Ca2+ concentration (P < 0.05), and the rapamycin-treated cells exhibited significantly decreased p-mTOR expression (P < 0.05). No significant difference was found in TNF-α, IL-1β or intracellular Ca2+ concentration between the normal control and rapamycin-treated cells (P>0.05). Compared with the menthol-treated cells, the cells treated with both menthol and rapamycin showed significantly decreased TNF- α, IL-1β, and p-mTOR expression and obviously lowered intracellular Ca2+ concentration (P < 0.05). CONCLUSIONS: Menthol promotes the expressions of airway inflammationrelated factors IL-1β and TNF-α possibly by activating mTOR to cause the increase of intracellular Ca2+ concentration.
airway inflammation; human bronchial epithelial cells; mammalian target of rapamycin; menthol; transient receptor potential melastatin 8
[Role of mammalian target of rapamycin activation in menthol-induced expressions of airway inflammation-related factors in human bronchial epithelial cells in vitro].
Chen H1, Li M1.
2019 Nov 30
to evaluate the effectiveness of menthol chewing gum, in the relief of the intensity and discomfort of the surgical patient’s thirst in the preoperative period.
a randomized controlled trial, with 102 patients in the preoperative period, randomized in a control group, with usual care, and an experimental group, which received menthol gum, which was the study treatment variable. The primary clinical outcome was the variation in thirst intensity, evaluated by the Numeral Verbal Scale, and the secondary, the variation of the discomfort of thirst, evaluated by the Perioperative Thirst Discomfort Scale. Mann-Whitney test was used to compare measures between groups. The significance level adopted was of 0.05.
menthol chewing gum significantly reduced the intensity (p <0.001), with Cohen's medium-effect d, and thirst discomfort (p <0.001), with a large-effect Cohen's d. CONCLUSION: menthol chewing gum was effective in reducing the intensity and discomfort of preoperative thirst. The strategy proved to be an innovative, feasible and safe option in the use for the surgical patient, in the management of the preoperative thirst, in elective surgeries. NCT: 03200197.
Menthol chewing gum on preoperative thirst management: randomized clinical trial.
Garcia AKA1,2,3, Furuya RK4, Conchon MF5, Rossetto EG6, Dantas RAS5, Fonseca LF6.
2019 Oct 7
The variations in average particle size, zeta potential, free fatty acids (FFA) release rate, and the bioavailability of menthol under in vitro simulated digestion conditions of peppermint oil nanoemulsion were investigated. 3D confocal laser scanning microscopy and Cryo-scanning electron microscopy were used to observe the microstructure characteristics of peppermint oil nanoemulsion, which indicated that soybean protein was completely adsorbed at the oil-water interface of the nanoemulsion and presented a core shell structure. And the results indicated that FFA release rate and menthol bioavailability of peppermint oil nanoemulsion prepared by using high-pressure homogenization were much higher. In the simulated gastric digestion phase, the average particle size and the zeta potential of the nanoemulsion increased, and droplet polymerization appeared. After the simulated intestinal, the interfacial protein of nanoemulsion was hydrolyzed, and the oil droplets were digested, which resulted in the decreased particle size and increased absolute value of zeta potential.
bioavailability; in vitro digestion; microstructure characteristics; nanoemulsion; peppermint oil
In vitro Simulated Digestion and Microstructure of Peppermint Oil Nanoemulsion.
Zhu Y1,2, Zhou Y1, Tian T1, Wang Z1, Qi B1, Zhang X1, Liu J3, Li Y1,2, Jiang L1,2, Wang Z1,2.