This product is isolated and purified from the roots of Glycyrrhiza uralensis Fisch
docosyl 3,4-dihydroxy-E-cinnamate/docosyl caffeate/docosyl-3,4-dihyroxy-trans-cinnamate/ETHYL ALL CIS-7,10,13,16,19-DOCOSAPENTAENOATE/docosapentaenoic acid ethyl ester/Docosyl (2E)-3-(3,4-dihydroxyphenyl)acrylate/ALL CIS 7-10-13-16-19 DPA ETHYL ESTER/2-Propenoic acid, 3-(3,4-dihydroxyphenyl)-, docosyl ester, (2E)-/docosapentanoic acid ethyl ester/DPA ETHYL ESTER/all cis-7,10,13,16,19-Docosapentaenoic Acid Ethyl Ester DPA Ethyl Ester
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
604.0±45.0 °C at 760 mmHg
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Personal Projective Equipment
For Reference Standard and R&D, Not for Human Use Directly.
provides coniferyl ferulate(CAS#:28593-92-2) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate
Despite the epidemic of cardiovascular disease and the benefits of cardiac rehabilitation (CR), availability is known to be insufficient, although this is not quantified. This study ascertained CR availability, volumes and its drivers, and density.
A survey was administered to CR programs globally. Cardiac associations and local champions facilitated program identification. Factors associated with volumes were assessed using generalized linear mixed models, and compared by World Health Organization region. Density (i.e. annual ischemic heart disease [IHD] incidence estimate from Global Burden of Disease study divided by national CR capacity) was computed.
CR was available in 111/203 (54.7%) countries; data were collected in 93 (83.8% country response; N = 1082 surveys, 32.1% program response rate). Availability by region ranged from 80.7% of countries in Europe, to 17.0% in Africa (p < .001). There were 5753 programs globally that could serve 1,655,083 patients/year, despite an estimated 20,279,651 incident IHD cases globally/year. Volume was significantly greater where patients were systematically referred (odds ratio [OR] = 1.36, 95% confidence interval [CI] = 1.35-1.38) and programs offered alternative models (OR = 1.05, 95%CI = 1.04-1.06), and significantly lower with private (OR = .92, 95%CI = .91-.93) or public (OR = .83, 95%CI = .82-84) funding compared to hybrid sources. Median capacity (i.e., number of patients a program could serve annually) was 246/program (Q25-Q75 = 150-390). The absolute density was one CR spot per 11 IHD cases in countries with CR, and 12 globally. Interpretation CR is available in only half of countries globally. Where offered, capacity is grossly insufficient, such that most patients will not derive the benefits associated with participation.
Cardiac rehabilitation, Capacity, Density, Preventive cardiology, Global health, Health services
Cardiac Rehabilitation Availability and Density around the Globe☆
Karam Turk-Adawi,a Marta Supervia,b,c Francisco Lopez-Jimenez,c Ella Pesah,d Rongjing Ding,e Raquel R. Britto,f Birna Bjarnason-Wehrens,g Wayne Derman,h Ana Abreu,i Abraham S. Babu,j Claudia Anchique Santos,k Seng Khiong Jong,l Lucky Cuenza,m Tee Joo Yeo,n Dawn Scantlebury,o Karl Andersen,p Graciela Gonzalez,q Vojislav Giga,r Dusko Vulic,s Eleonora Vataman,t Jacqueline Cliff,u Evangelia Kouidi,v Ilker Yagci,w Chul Kim,x Briseida Benaim,y Eduardo Rivas Estany,z Rosalia Fernandez,aa Basuni Radi,ab Dan Gaita,ac Attila Simon,ad Ssu-Yuan Chen,ae Brendon Roxburgh,af Juan Castillo Martin,ag Lela Maskhulia,ah Gerard Burdiat,ai Richard Salmon,aj Hermes Lomeli,ak Masoumeh Sadeghi,al Eliska Sovova,am Arto Hautala,an Egle Tamuleviciute-Prasciene,ao Marco Ambrosetti,ap Lis Neubeck,aq Elad Asher,ar Hareld Kemps,as Zbigniew Eysymontt,at Stefan Farsky,au Jo Hayward,av Eva Prescott,aw Susan Dawkes,ax Claudio Santibanez,ay Cecilia Zeballos,az Bruno Pavy,ba Anna Kiessling,bb Nizal Sarrafzadegan,al,bc Carolyn Baer,bd Randal Thomas,c Dayi Hu,be and Sherry L. Graced,bf,⁎
Lentil (Lens culinaris Medikus) is an important source of protein for people in developing countries. Aphanomyces root rot (ARR) has emerged as one of the most devastating diseases affecting lentil production. In this study, we applied two complementary quantitative trait loci (QTL) analysis approaches to unravel the genetic architecture underlying this complex trait. A recombinant inbred line (RIL) population and an association mapping population were genotyped using genotyping by sequencing (GBS) to discover novel single nucleotide polymorphisms (SNPs). QTL mapping identified 19 QTL associated with ARR resistance, while association mapping detected 38 QTL and highlighted accumulation of favorable haplotypes in most of the resistant accessions. Seven QTL clusters were discovered on six chromosomes, and 15 putative genes were identified within the QTL clusters. To validate QTL mapping and genome-wide association study (GWAS) results, expression analysis of five selected genes was conducted on partially resistant and susceptible accessions. Three of the genes were differentially expressed at early stages of infection, two of which may be associated with ARR resistance. Our findings provide valuable insight into the genetic control of ARR, and genetic and genomic resources developed here can be used to accelerate development of lentil cultivars with high levels of partial resistance to ARR.
Aphanomyces euteiches, candidate genes, GBS, GWAS, lentil, linkage disequilibrium (LD), QTL mapping, root rot, SNP
Dissecting the Genetic Architecture of Aphanomyces Root Rot Resistance in Lentil by QTL Mapping and Genome-Wide Association Study
Yu Ma,1 Afef Marzougui,2 Clarice J. Coyne,3 Sindhuja Sankaran,2 Dorrie Main,1 Lyndon D. Porter,4 Deus Mugabe,5 Jamin A. Smitchger,5 Chongyuan Zhang,2 Md. Nurul Amin,6 Naser Rasheed,7 Stephen P. Ficklin,1 and Rebecca J. McGee8,*
Higher prevalence of suicide notes could signify more conservatism in accounting and greater proneness to undercounting of suicide by method. We tested two hypotheses: (1) an evidentiary suicide note is more likely to accompany suicides by drug-intoxication and by other poisoning, as less violent and less forensically overt methods, than suicides by firearm and hanging/suffocation; and (2) performance of a forensic autopsy attenuates any observed association between overtness of method and the reported presence of a note.
This multilevel (individual/county), multivariable analysis employed a generalized linear mixed model (GLMM). Representing the 17 states participating in the United States National Violent Death Reporting System throughout 2011-2013, the study population comprised registered suicides, aged 15 years and older. Decedents totaled 32,151. The outcome measure was relative odds of an authenticated suicide note.
An authenticated suicide note was documented in 31% of the suicide cases. Inspection of the full multivariable model showed a suicide note was more likely to manifest among drug intoxication (adjusted odds ratio [OR], 1.70; 95% CI, 1.56, 1.85) and other poisoning suicides (OR, 2.12; 1.85, 2.42) than firearm suicides, the referent. Respective excesses were larger when there was no autopsy or autopsy status was unknown (OR, 1.86; 95% CI, 1.61, 2.14) and (OR, 2.25; 95% CI, 1.86, 2.72) relative to the comparisons with a forensic autopsy (OR, 1.62, 95% CI, 1.45, 1.82 and OR, 2.01; 95% CI, 1.66, 2.43). Hanging/suffocation suicides did not differ from the firearm referent given an autopsy.
Suicide requires substantial affirmative evidence to establish manner of death, and affirmation of drug intoxication suicides appears to demand an especially high burden of proof. Findings and their implications argue for more stringent investigative standards, better training, and more resources to support comprehensive and accurate case ascertainment, as the foundation for developing evidence-based suicide prevention initiatives.
Method overtness, forensic autopsy, and the evidentiary suicide note: A multilevel National Violent Death Reporting System analysis
Ian R. H. Rockett, Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing - original draft, Writing - review & editing,1,2,* Eric D. Caine, Funding acquisition, Writing - original draft, Writing - review & editing,3,4 Steven Stack, Writing - review & editing,5,6 Hilary S. Connery, Writing - review & editing,7,8 Kurt B. Nolte, Writing - review & editing,9 Christa L. Lilly, Writing - review & editing,10 Ted R. Miller, Writing - review & editing,11,12 Lewis S. Nelson, Writing - review & editing,13 Sandra L. Putnam, Writing - review & editing,2 Paul S. Nestadt, Writing - review & editing,14,15 and Haomiao Jia, Data curation, Formal analysis, Investigation, Methodology, Resources, Software, Validation, Writing - original draft, Writing - review & editing16,17