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Donepezil hydrochloride

$64

  • Brand : BIOFRON

  • Catalogue Number : BN-O1017

  • Specification : 98%(HPLC)

  • CAS number : 120011-70-3

  • Formula : C24H30ClNO3

  • Molecular Weight : 415.95

  • PUBCHEM ID : 5741

  • Volume : 5mg

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Catalogue Number

BN-O1017

Analysis Method

Specification

98%(HPLC)

Storage

-20℃

Molecular Weight

415.95

Appearance

Powder

Botanical Source

Structure Type

Category

SMILES

COC1=C(C=C2C(=C1)CC(C2=O)CC3CCN(CC3)CC4=CC=CC=C4)OC.Cl

Synonyms

2-(1-Benzyl-4-piperidylmethyl)-5,6-dimethoxy-1-indanone Hydrochloride/2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one hydrochloride (1:1)/2-[(1-Benzyl-4-piperidinyl)methyl]-5,6-dimethoxy-1-indanone hydrochloride (1:1)/2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one hydrochloride/5,6-Dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-2,3-dihydro-1H-inden-1-one Hydrochloride/2-((1-Benzylpiperidin-4-yl)methyl)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one hydrochloride/1H-Inden-1-one, 2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-, hydrochloride (1:1)/2-[(1-Benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydro-1H-inden-1-onhydrochlorid/2-[(1-Benzyl-4-piperidinyl)methyl]-5,6-dimethoxy-1-indanone hydrochloride/1H-inden-1-one, 2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-, hydrochloride/2,3-Dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-one hydrochloride/1-Benzyl-4-[(5,6-dimethoxy-1-indanon-2-yl)methyl]piperidine Hydrochloride/Donepezil HCl/2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one hydrochloride/Donepezil hydrochloride/2-[(1-Benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one hydrochloride (1:1)/Donepezil

IUPAC Name

Density

Solubility

Flash Point

273.1ºC

Boiling Point

527.9ºC at 760 mmHg

Melting Point

220-222ºC

InChl

InChI=1S/C18H12O6/c1-21-11-7-12-13(8-5-6-22-18(8)24-12)17-15(11)16(20)14-9(19)3-2-4-10(14)23-17/h2-8,18-19H,1H3/t8-,18+/m0/s1

InChl Key

XWAIAVWHZJNZQQ-UHFFFAOYSA-N

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:120011-70-3) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

27252988

Abstract

Donepezil (and other cholinesterase inhibitors [ChEIs]) and memantine are the mainstays of treatment in Alzheimer’s dementia, addressing respectively, the cholinergic and glutamatergic dysregulation which underlies or results from its pathophysiology. To alleviate the pill burden and swallowing difficulties associated with the condition, a fixed drug combination of extended-release memantine and donepezil was developed. This combination was shown to be both bioequivalent to the components administered separately and could be administered sprinkled over soft food. The mode of action, pharmacokinetics, clinical efficacy and safety and tolerability of the combination are discussed together with the wider, often conflicting trial literature of combination versus monotherapy with memantine and ChEIs, their meta-analyses and treatment guidelines.

KEYWORDS

Alzheimer's disease; Cholinesterase inhibitors; Donepezil; Memantine; Neurologic drugs. Copyright 2016 Prous Science, S.A.U. or its licensors. All rights reserved.

Title

Memantine and Donepezil: A Fixed Drug Combination for the Treatment of Moderate to Severe Alzheimer's Dementia

Author

R T Owen 1

Publish date

2016 Apr

PMID

28937413

Title

Pharmacological Treatment for Memory Disorder in Multiple Sclerosis

Author

Susan Bellman 1

Publish date

Dec-17

PMID

28409590

Title

Alzheimer Disease: Monotherapy vs. Combination Therapy

Author

Elisabeth Lawler 1, Amber Avila 1

Publish date

2017 Apr 1


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