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Dyphylline

$53

  • Brand : BIOFRON

  • Catalogue Number : BN-O1246

  • Specification : 98%(HPLC)

  • CAS number : 479-18-5

  • Formula : C10H14N4O4

  • Molecular Weight : 254.24

  • PUBCHEM ID : 3182

  • Volume : 5mg

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Catalogue Number

BN-O1246

Analysis Method

Specification

98%(HPLC)

Storage

-20℃

Molecular Weight

254.24

Appearance

Powder

Botanical Source

Structure Type

Category

SMILES

CN1C2=C(C(=O)N(C1=O)C)N(C=N2)CC(CO)O

Synonyms

Neutraphylline/COR-theophylline/Neutrafil/Teofen/Circain/Dyflex/Neostenovasan/Propyphyllin/Circair/7-(2,3-Dihydroxypropyl)-1,3-dimethylxanthine/7-(2,3-Dihydroxypropyl)-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione/Theophylline, 7- (2,3-dihydroxypropyl)-/Coronal/dilor/Hyphylline/tesfen/Diphylline/Airet/(1,2-Dihydroxy-3-propyl)theophylline/Lufyllin/Solufilin/Solufyllin/diprophylline/Asthmolysin/7-(2,3-Dihydroxypropyl)theophylline,Dyphylline/7-(β,γ-Dihydroxypropyl)theophylline/Neufil/Coronarin/Theal/Aristophyllin/Thefylan/Dyphylline/Astmamasit/7-(b,g-Dihydroxypropyl)theophylline/7-(2,3-Dihydroxypropyl)theophylline/1H-Purine-2,6-dione, 7-(2,3-dihydroxypropyl)-3,7-dihydro-1,3-dimethyl-/7-(2,3-dihydroxyprop-1-yl)theophylline

IUPAC Name

Density

1.6±0.1 g/cm3

Solubility

Flash Point

310.4±32.9 °C

Boiling Point

589.6±60.0 °C at 760 mmHg

Melting Point

161-162 °C(lit.)

InChl

InChl Key

KSCFJBIXMNOVSH-UHFFFAOYSA-N

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:479-18-5) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

30000536

Title

Dyphylline

Publish date

2018 Oct 31.

PMID

7073120

Title

Theophylline Toxicity After Dyphylline Therapy

Author

B L Ackerman, A Chhatriwalla

Publish date

1982 Apr;

PMID

28487190

Abstract

The aim of this study was to elucidate the importance of potential limited solubility effects for the control of drug release from hydrophilic matrix tablets loaded with a freely water-soluble drug. It is often assumed that the considerable amounts of water penetrating into this type of advanced drug delivery systems are sufficient to rapidly dissolve the entire drug loading, and that limited drug solubility is not playing a role for the control of drug release. Here, we show that this assumption can be erroneous. HPMC/lactose matrix tablets were loaded with 5 to 60% diprophylline (e.g. solubility in 0.1M HCl at 37°C: 235mg/mL), and drug release was measured at low and neutral pH, respectively. A mechanistically realistic mathematical theory was applied, considering drug diffusion in axial and radial direction in the cylindrical matrices and the potential co-existence of dissolved and non-dissolved drug. Importantly, only dissolved drug is available for diffusion. It is demonstrated that during major parts of the release periods, non-dissolved drug excess exists within tablets containing 30% or more diprophylline, despite of the substantial water contents of the systems. This leads to partially almost linear drug concentration distance profiles within the tablets, and reveals a major contribution of limited drug solubility effects to the control of drug release, even in the case of freely water-soluble diprophylline. It can be expected that also in other types of drug delivery systems, e.g. microparticles and implants (containing much less water), limited drug solubility effects play a much more important role than currently recognized.

KEYWORDS

Diffusion; Diprophylline; Drug release mechanism; HPMC tablet; Mathematical modeling; Solubility.

Title

Limited Drug Solubility Can Be Decisive Even for Freely Soluble Drugs in Highly Swollen Matrix Tablets

Author

F Siepmann 1, Y Karrout 1, M Gehrke 1, F K Penz 2, J Siepmann 3

Publish date

2017 Jun 30


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