We Offer Worldwide Shipping
Login Wishlist

Emodin

$43

  • Brand : BIOFRON

  • Catalogue Number : BF-E1007

  • Specification : 98%

  • CAS number : 518-82-1

  • Formula : C15H10O5

  • Molecular Weight : 270.24

  • PUBCHEM ID : 3220

  • Volume : 20mg

In stock

Quantity
Checkout Bulk Order?

Catalogue Number

BF-E1007

Analysis Method

HPLC,NMR,MS

Specification

98%

Storage

2-8°C

Molecular Weight

270.24

Appearance

Orange crystalline powder

Botanical Source

Periploca forrestii,Sarcandra glabra,Rheum palmatum,Reynoutria japonica,Chrysanthemum morifolium

Structure Type

Alkaloids

Category

Standards;Natural Pytochemical;API

SMILES

CC1=CC2=C(C(=C1)O)C(=O)C3=C(C2=O)C=C(C=C3O)O

Synonyms

6-Methyl-1,3,8-trihydroxyanthraquinone/Ecdyson/1,3,8-Trihydroxy-6-methylanthracene-9,10-dione/Alatinone/1,3,8-Trihydroxy-6-methylanthraquinone/EMODINE/1,3,8-Tri-hydroxy-6-methyl-anthra-quinone/Emodin/EMODIN 99/1,3,8-trihydroxy-6-methyl-9,10-anthraquinone/EMODOL/Archin/schuttgelb/Emdin

IUPAC Name

1,3,8-trihydroxy-6-methylanthracene-9,10-dione

Density

1.6±0.1 g/cm3

Solubility

Methanol; DMF; DMSO

Flash Point

322.8±23.6 °C

Boiling Point

586.9±39.0 °C at 760 mmHg

Melting Point

255 °C (dec.)(lit.)

InChl

InChl Key

WGK Germany

RID/ADR

HS Code Reference

2914690000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:518-82-1) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

PMID

27188216

Abstract

Emodin is a natural anthraquinone derivative that occurs in many widely used Chinese medicinal herbs, such as Rheum palmatum, Polygonum cuspidatum and Polygonum multiflorum. Emodin has been used as a traditional Chinese medicine for over 2000 years and is still present in various herbal preparations. Emerging evidence indicates that emodin possesses a wide spectrum of pharmacological properties, including anticancer, hepatoprotective, antiinflammatory, antioxidant and antimicrobial activities. However, emodin could also lead to hepatotoxicity, kidney toxicity and reproductive toxicity, particularly in high doses and with long-term use. Pharmacokinetic studies have demonstrated that emodin has poor oral bioavailability in rats because of its extensive glucuronidation. This review aims to comprehensively summarize the pharmacology, toxicity and pharmacokinetics of emodin reported to date with an emphasis on its biological properties and mechanisms of action.

Copyright © 2016 John Wiley & Sons, Ltd.

KEYWORDS

emodin; mechanisms; pharmacokinetics; pharmacology; toxicology

Title

Emodin: A Review of its Pharmacology, Toxicity and Pharmacokinetics.

Author

Dong X1, Fu J1, Yin X1, Cao S1, Li X1, Lin L1; Huyiligeqi, Ni J1.

Publish date

2016 Aug

PMID

27671812

Abstract

Diseases, such as heart disease, stroke, cancer, respiratory diseases, and diabetes, are by far the leading cause of mortality in the world, representing 60 % of all deaths. Although substantial medical advances have been made and many therapeutic approaches proposed yet traditional medicine and medicinal plants find an important place in therapy. They have been providing invaluable solutions to the various health problems. Emodin (1,3,8-trihydroxy-6-methylanthraquinone) is a natural anthraquinone derivative found in various Chinese medicinal herbs. Traditionally, it has been used as an active constituent of many herbal laxatives. However, in the last few years, significant progress has been made in studying the biological effects of emodin at cellular and molecular levels and it is emerging as an important therapeutic agent. This review provides an overview of the modulatory effects of emodin in various diseases and cell signaling pathways, which may have important implications in its future clinical use.

KEYWORDS

Anthraquinone; Bioavailability; Cancer; Chemosesitizer; Emodin; Radiosensitizer

Title

Emodin and Its Role in Chronic Diseases.

Author

Monisha BA1, Kumar N2, Tiku AB3.

Publish date

2016

PMID

32246183

Abstract

In the original publication of the article.

Erratum for
Emodin alleviated pulmonary inflammation in rats with LPS-induced acute lung injury through inhibiting the mTOR/HIF-1α/VEGF signaling pathway. [Inflamm Res. 2020]

Title

Correction to: Emodin alleviated pulmonary inflammation in rats with LPS-induced acute lung injury through inhibiting the mTOR/HIF-1α/VEGF signaling pathway.

Author

Li X1,2, Shan C1,2, Wu Z1,2, Yu H1,2, Yang A3,4, Tan B5.

Publish date

2020 Apr 3


Description :

Emodin is a broad-spectrum anticancer agent. Emodin inhibits casein kinase II (CKII) activity with IC50 of 2 μM.