Catalogue Number
BF-E1007
Analysis Method
HPLC,NMR,MS
Specification
98%
Storage
2-8°C
Molecular Weight
270.24
Appearance
Orange crystalline powder
Botanical Source
Periploca forrestii,Sarcandra glabra,Rheum palmatum,Reynoutria japonica,Chrysanthemum morifolium
Structure Type
Alkaloids
Category
Standards;Natural Pytochemical;API
SMILES
CC1=CC2=C(C(=C1)O)C(=O)C3=C(C2=O)C=C(C=C3O)O
Synonyms
6-Methyl-1,3,8-trihydroxyanthraquinone/Ecdyson/1,3,8-Trihydroxy-6-methylanthracene-9,10-dione/Alatinone/1,3,8-Trihydroxy-6-methylanthraquinone/EMODINE/1,3,8-Tri-hydroxy-6-methyl-anthra-quinone/Emodin/EMODIN 99/1,3,8-trihydroxy-6-methyl-9,10-anthraquinone/EMODOL/Archin/schuttgelb/Emdin
IUPAC Name
1,3,8-trihydroxy-6-methylanthracene-9,10-dione
Density
1.6±0.1 g/cm3
Solubility
Methanol; DMF; DMSO
Flash Point
322.8±23.6 °C
Boiling Point
586.9±39.0 °C at 760 mmHg
Melting Point
255 °C (dec.)(lit.)
InChl
InChl Key
WGK Germany
RID/ADR
HS Code Reference
2914690000
Personal Projective Equipment
Correct Usage
For Reference Standard and R&D, Not for Human Use Directly.
Meta Tag
provides coniferyl ferulate(CAS#:518-82-1) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate
COA
27188216
Emodin is a natural anthraquinone derivative that occurs in many widely used Chinese medicinal herbs, such as Rheum palmatum, Polygonum cuspidatum and Polygonum multiflorum. Emodin has been used as a traditional Chinese medicine for over 2000 years and is still present in various herbal preparations. Emerging evidence indicates that emodin possesses a wide spectrum of pharmacological properties, including anticancer, hepatoprotective, antiinflammatory, antioxidant and antimicrobial activities. However, emodin could also lead to hepatotoxicity, kidney toxicity and reproductive toxicity, particularly in high doses and with long-term use. Pharmacokinetic studies have demonstrated that emodin has poor oral bioavailability in rats because of its extensive glucuronidation. This review aims to comprehensively summarize the pharmacology, toxicity and pharmacokinetics of emodin reported to date with an emphasis on its biological properties and mechanisms of action.
Copyright © 2016 John Wiley & Sons, Ltd.
emodin; mechanisms; pharmacokinetics; pharmacology; toxicology
Emodin: A Review of its Pharmacology, Toxicity and Pharmacokinetics.
Dong X1, Fu J1, Yin X1, Cao S1, Li X1, Lin L1; Huyiligeqi, Ni J1.
2016 Aug
27671812
Diseases, such as heart disease, stroke, cancer, respiratory diseases, and diabetes, are by far the leading cause of mortality in the world, representing 60 % of all deaths. Although substantial medical advances have been made and many therapeutic approaches proposed yet traditional medicine and medicinal plants find an important place in therapy. They have been providing invaluable solutions to the various health problems. Emodin (1,3,8-trihydroxy-6-methylanthraquinone) is a natural anthraquinone derivative found in various Chinese medicinal herbs. Traditionally, it has been used as an active constituent of many herbal laxatives. However, in the last few years, significant progress has been made in studying the biological effects of emodin at cellular and molecular levels and it is emerging as an important therapeutic agent. This review provides an overview of the modulatory effects of emodin in various diseases and cell signaling pathways, which may have important implications in its future clinical use.
Anthraquinone; Bioavailability; Cancer; Chemosesitizer; Emodin; Radiosensitizer
Emodin and Its Role in Chronic Diseases.
Monisha BA1, Kumar N2, Tiku AB3.
2016
32246183
In the original publication of the article.
Erratum for
Emodin alleviated pulmonary inflammation in rats with LPS-induced acute lung injury through inhibiting the mTOR/HIF-1α/VEGF signaling pathway. [Inflamm Res. 2020]
Correction to: Emodin alleviated pulmonary inflammation in rats with LPS-induced acute lung injury through inhibiting the mTOR/HIF-1α/VEGF signaling pathway.
Li X1,2, Shan C1,2, Wu Z1,2, Yu H1,2, Yang A3,4, Tan B5.
2020 Apr 3
