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ent-6,11-Dihydroxy-15-oxo-16-kauren-19-oic acid beta-D-glucopyranosyl ester

$1,120

  • Brand : BIOFRON

  • Catalogue Number : BN-O0573

  • Specification : 95%(HPLC)

  • CAS number : 81263-97-0

  • Formula : C26H38O10

  • Molecular Weight : 510.57

  • PUBCHEM ID : 98049792

  • Volume : 5mg

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Catalogue Number

BN-O0573

Analysis Method

HPLC,NMR,MS

Specification

95%(HPLC)

Storage

-20℃

Molecular Weight

510.57

Appearance

Cryst.

Botanical Source

This product is isolated and purified from the herbs of Pteris semipinnata

Structure Type

Diterpenoids

Category

Standards;Natural Pytochemical;API

SMILES

CC12CCCC(C1C(CC34C2C(CC(C3)C(=C)C4=O)O)O)(C)C(=O)OC5C(C(C(C(O5)CO)O)O)O

Synonyms

1-O-[(5β,6β,8α,9β,10α,11β,13α)-6,11-Dihydroxy-15,18-dioxokaur-16-en-18-yl]-β-D-glucopyranose/1-O-[(5β,8α,9β,10α)-6,11-Dihydroxy-15,18-dioxokaur-16-en-18-yl]-β-D-glucopyranose

IUPAC Name

[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] (1S,3R,4S,5R,9S,10S,11S,13S)-3,11-dihydroxy-5,9-dimethyl-14-methylidene-15-oxotetracyclo[11.2.1.01,10.04,9]hexadecane-5-carboxylate

Applications

Density

1.4±0.1 g/cm3

Solubility

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

Flash Point

236.9±26.4 °C

Boiling Point

713.4±60.0 °C at 760 mmHg

Melting Point

InChl

InChI=1S/C26H38O10/c1-11-12-7-13(28)20-24(2)5-4-6-25(3,19(24)14(29)9-26(20,8-12)21(11)33)23(34)36-22-18(32)17(31)16(30)15(10-27)35-22/h12-20,22,27-32H,1,4-10H2,2-3H3/t12-,13+,14-,15-,16-,17+,18-,19+,20+,22+,24-,25-,26+/m1/s1

InChl Key

OIMCIPSRGXJJFP-OHHFPUJUSA-N

WGK Germany

RID/ADR

HS Code Reference

2933990000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:81263-97-0) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

21754845

Abstract

The crystal structure of the title compound, C25H31NO3, exists in a twin-chair conformation with an equatorial orientation of the ortho-eth­oxy­phenyl groups. According to Cremer and Pople [Cremer & Pople (1975 ▶), J. Am. Chem. Soc. 97, 1354-1358], both the piperidone and cyclo­hexa­none rings are significantly puckered with total puckering amplitutdes Q T of 0.5889 (18) and 0.554 (2) a, respectively. The ortho-eth­oxy­phenyl groups are located on either side of the secondary amino group and make a dihedral angle of 12.41 (4)° with respect to each other. The methyl group on the cyclo­hexa­none part occupies an exocyclic equatorial disposition. The crystal packing is stabilized by weak van der Waals inter­actions.

Title

2,4-Bis(2-eth­oxy­phen­yl)-7-methyl-3-aza­bicyclo­[3.3.1]nonan-9-one

Author

P. Parthiban,a V. Ramkumar,b Dong Ho Park,c and Yeon Tae Jeonga,*

Publish date

2011 Jun 1;

PMID

26230320

Abstract

Objective
For various reasons, people of Chinese (China, Hong Kong or Taiwan) and South Asian (Indian subcontinent) ancestry (the two largest ethnic minority groups in Ontario, Canada) may be less likely to register for deceased organ donation than the general public, and their families may be less likely to consent for deceased organ donation at the time of death.

Methods
We conducted two population-based studies: (1) a cross-sectional study of deceased organ donor registration as of May 2013, and (2) a cohort study of the steps in proceeding with deceased organ donation for patients who died in hospital from October 2008 to December 2012.

Results
A total of 49 938 of 559 714 Chinese individuals (8.9%) and 47 774 of 374 291 South Asians (12.8%) were registered for deceased organ donation, proportions lower than the general public (2 676 260 of 10 548 249 (25.4%). Among the 168 703 Ontarians who died in a hospital, the families of 33 of 81 Chinese (40.1%; 95% CI: 30.7%-51.6%) and 39 of 72 South Asian individuals (54.2%; 95% CI: 42.7-65.2%) consented for deceased organ donation, proportions lower than the general public (68.3%; 95% CI: 66.4%-70.0%).

Conclusions
In Ontario, Canada Chinese and South Asian individuals are less likely to register and their families are less likely to consent to deceased organ donation compared to the remaining general public. There is an opportunity to build support for organ and tissue donation in these two large ethnic communities in Canada.

Title

Deceased Organ Donation Registration and Familial Consent among Chinese and South Asians in Ontario, Canada

Author

Alvin Ho-ting Li, 1 ,* Eric McArthur, 2 Janet Maclean, 3 Cynthia Isenor, 3 Versha Prakash, 3 S. Joseph Kim, 2 , 4 Greg Knoll, 5 Baiju Shah, 2 , 6 and Amit X. Garg 1 , 2

Publish date

2015;

PMID

28052758

Abstract

Background
Health-related quality-of-life (HRQOL) assessment with EORTC QLQ-C30 was prognostic for overall survival (OS) in patients with advance-stage hepatocellular carcinoma (HCC), but no data existed for early-stage patients. The HCC-specific QLQ-HCC18 has not been evaluated for prognostic value in HCC patients. Utilization of raw HRQOL data in clinical setting has been impractical and non-meaningful. Therefore we developed index scores of QLQ-C30 and QLQ-HCC18 in an attempt to enable clinical utilization of these HRQOL measurements. This study investigates the prognostic significance of QLQ-C30, QLQ-HCC18 and C30/HCC18 index-scores in patients with newly diagnosed HCC which encompasses all stages.

Methods
From 2007-2011, 517 patients were prospectively recruited. HRQOL was assessed at diagnosis using QLQ-C30 and QLQ-HCC18; C30 and HCC18 index-scores were calculated from raw HRQOL data. Cox regression was performed using continuous, dichotomized QLQ-C30 and QLQ-HCC18 variables, or index-scores, together with clinical factors to identify independent factors for OS. Various multivariate models were validated with c-index and bootstrapping for 1000 replications.

Results
Four hundred and seventy two patients had complete HRQOL data. Their median OS was 8.6 months. In multivariate analysis, independent prognostic HRQOL variables for OS were QLQ-C30 pain (HR 1.346 [1.092-1.661], p = 0.0055), QLQ-C30 physical functioning (HR 0.652 [0.495-0.860], p = 0.0024); QLQ-HCC18 pain (HR 1.382 [1.089-1.754], p = 0.0077) and QLQ-HCC18 fatigue (HR 1.441 [1.132-1.833], p = 0.0030). C30 index-score (HR 2.143 [1.616-2.841], p < 0.0001) and HCC18 index-score (HR 1.957 [1.411-2.715], p < 0.0001) were highly significant factors for OS. The median OS of patients with C30 index-score of 0-20, 21-40, 41-60, 61-100 were 16.4, 7.3, 3.1, 1.8 months respectively (p < 0.0001); while for HCC18 index-score: 16.4, 6.0, 2.8, 1.8 months respectively (p < 0.0001). All the multivariate models were validated, with mean optimism <0.01. The bootstrap validated c-index was 0.78.

Conclusions
QLQ-C30 and QLQ-HCC18 were prognostic for OS in patients with newly diagnosed HCC irrespective of stage. Both C30 and HCC18 index-scores were highly significant prognostic factors for OS in newly diagnosed HCC patients. Index-scoring provides an effective way to summarize, analyze and interpret raw HRQOL data, and renders QLQ-C30 and QLQ-HCC18 meaningful and communicable in clinical practice. Index-scores could potentially serve as a standardized tool for future HRQOL research.

KEYWORDS

Health-related quality-of-life, QLQ-HCC18, QLQ-C30, Index-score, Prognosis, Overall survival, Hepatocellular carcinoma, Liver cancer

Title

Prognostic values of EORTC QLQ-C30 and QLQ-HCC18 index-scores in patients with hepatocellular carcinoma - clinical application of health-related quality-of-life data

Author

Leung Li,1 Frankie KF Mo,1 Stephen L Chan,1 Edwin P Hui,1 Nelson SL Tang,4 Jane Koh,1 Linda KS Leung,1 Annette NY Poon,1 Joyce Hui,2 Cheuk M Chu,2 Kit F Lee,3 Brigette BY Ma,1 Paul BS Lai,3 Anthony TC Chan,1 Simon CH Yu,2 and Winnie Yeocorresponding author1

Publish date

2017