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Equol

$90

Brand : BIOFRON
Catalogue Number : AV-H03048
Specification : 98%
CAS number : 531-95-3
Formula : C15H14O3
Molecular Weight : 242.27
PUBCHEM ID : 91469
Volume : 20mg

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Catalogue Number

AV-H03048

Analysis Method

HPLC,NMR,MS

Specification

98%

Storage

2-8°C

Molecular Weight

242.27

Appearance

White crystalline powder

Botanical Source

Structure Type

Flavonoids

Category

Standards;Natural Pytochemical;API

SMILES

C1C(COC2=C1C=CC(=C2)O)C3=CC=C(C=C3)O

Synonyms

(3S)-3-(4-Hydroxyphenyl)chroman-7-ol/(3S)-3-(4-hydroxyphenyl)-3,4-dihydro-2H-chromen-7-ol/Equol/(3S)-3-(4-Hydroxyphenyl)-7-chromanol/(S)-Equol/(-)-Equol/4',7-DIHYDROXYISOFLAVAN/(S)-3-(4-Hydroxyphenyl)chroman-7-ol/R,S-EQUOL/7,4'-ISOFLAVANDIOL/EQUOL, (-)-/2H-1-Benzopyran-7-ol, 3,4-dihydro-3-(4-hydroxyphenyl)-, (3S)-/4',7-ISOFLAVANDIOL/(-)-(S)-Equol

IUPAC Name

(3S)-3-(4-hydroxyphenyl)-3,4-dihydro-2H-chromen-7-ol

Density

1.3±0.1 g/cm3

Solubility

Soluble in DMSO > 10 mM

Flash Point

220.9±28.7 °C

Boiling Point

441.7±45.0 °C at 760 mmHg

Melting Point

189-190ºC

InChl

InChl Key

ADFCQWZHKCXPAJ-GFCCVEGCSA-N

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:531-95-3) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

31629309

Abstract

“Isoformononetin (methoxy isoflavone) is a potent osteogenic isoflavone abundantly present in Butea monosperma, Pisum sativum, Mung bean, Machaerium villosum, Medicago sativa, and Glycine max. In the current study, an LC-ESI-MS/MS method for the simultaneous evaluation of isoformononetin (IFN), daidzein (DZN) and equol (EQL) was developed and validated in rat plasma using biochanin A as an internal standard. IFN, DZN, and EQL separation was achieved by using acetonitrile and acetic acid (0.1%) in the ratio of 90:10 (% v/v) as mobile phase under isocratic conditions at a flow rate of 0.6?mL/min on Atlantis C18 (4.6?×?250?mm, 5.0?μm) column. The achieved method was linear within the concentration range of 0.5-500?ng/mL. The method was effectively applied to investigate the permeability, protein binding estimation and pharmacokinetics studies of IFN in rats. The PAMPA permeability of IFN was found to be high at pH?4.0 and 7.0. The protein binding was found to be about 91% of IFN. The oral bioavailability of IFN was found to be poor (21.6%). IFN was found to have a moderate clearance (2.9?L/h/kg) and a large apparent volume of distribution (12.1?L/kg). The plasma half-life (t1/2) and maximum attainable concentration (Cmax) of IFN at systemic circulation was found to be 1.9?±?0.6?h and 269.3?±?0.4 after oral administration.
Copyright ? 2019. Published by Elsevier B.V.”

KEYWORDS

Bioavailability; Isoflavone; Isoformononetin; Permeability; Pharmacokinetics

Title

LC-ESI-MS/MS method for the simultaneous determination of isoformononetin, daidzein, and equol in rat plasma: Application to a preclinical pharmacokinetic study.

Author

Raju KSR1, Rashid M2, Gundeti M2, Taneja I3, Malik MY2, Singh SK4, Chaturvedi S4, Challagundla M2, Singh SP5, Gayen JR2, Wahajuddin M6.

Publish date

2019 Oct 15

PMID

31601322

Abstract

“OBJECTIVE:
To investigate the effect of racemic equol and equol enantiomers on the proliferation of colorectal cancer HCT-15 cell and the potential mechanism.
METHODS:
3-( 4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide( MTT) assay was used to detect the effect of different concentrations of racemic equol and equol enantiomers( 0, 0. 5, 1, 5 and 10 μmol/L) on the proliferation of colorectal cancer HCT-15 cell. Western blot was used to detect the expression of estrogen receptor( ER)and nuclear factor 2 related factor 2( Nrf2).
RESULTS:
Racemic equol and( R) equol inhibited the proliferation of HCT-15 cell in a dose-dependent manner, whereas( S) equol had no effect on the proliferation of HCT-15 cell. Racemic equol increased the expression of ERβ and Nrf2, while( R) equol increased the expression of Nrf2.
CONCLUSION:
Racemic equol can inhibit the proliferation of HCT-15 cell through estrogenic and antioxidative activity. R equol can inhibit the proliferation of HCT-15 cell through antioxidative activity, while( S) equol has no effect on the proliferation of HCT-15 cell.”

KEYWORDS

HCT-15 cell; colorectal cancer; equol; equol enantiomers; estrogen receptor

Title

[Effects of equol on proliferation of colorectal cancer HCT-15 cell].

Author

Zou Y1, Wang Y1, Cai Y1, Ma D1.

Publish date

2019 Sep

PMID

31231095

Abstract

We previously found that daidzein decreased food intake in female rats. To understand the mechanism of anorectic action of dietary daidzein, it is necessary to determine distributions of daidzein and S-equol, a metabolite of intestinal bacterial conversion from daidzein, in the body. In the present study, we measured the concentrations of daidzein and S-equol in serum and bile in sham-operated and ovariectomized female rats fed a diet containing 150 mg/kg daidzein for 7 days. Dietary daidzein increased serum and bile concentrations of S-equol to far higher levels than those of daidzein. S-equol concentration was more than several hundred fold-higher in bile than in serum, regardless of ovariectomy. Moreover, to investigate whether accumulation of S-equol is facilitated by efficient enterohepatic circulation during continuous intake of daidzein and S-equol, female rats were fed diet containing daidzein or S-equol (both 150 mg/kg), or control diet for 1, 2, 3, or 5 days. Dietary daidzein significantly increased serum and bile concentrations of S-equol in a time-dependent manner, but not those of daidzein. These results indicated that substantial proportion of dietary daidzein was converted to S-equol, which underwent efficient enterohepatic circulation and predominantly accumulated there

Title

Dietary daidzein induces accumulation of S-equol in enterohepatic circulation to far higher levels than that of daidzein in female rats with and without ovariectomy.

Author

Fujitani M1, Mizushige T2, Bhattarai K1,3, Adhikari S3, Ishikawa J4, Kishida T1,3.

Publish date

2019