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Erythritol

$43

  • Brand : BIOFRON

  • Catalogue Number : BF-E3004

  • Specification : 98%

  • CAS number : 149-32-6

  • Formula : C4H10O4

  • Molecular Weight : 122.12

  • Volume : 100mg

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Catalogue Number

BF-E3004

Analysis Method

HPLC,NMR,MS

Specification

98%

Storage

-20℃

Molecular Weight

122.12

Appearance

Oil

Botanical Source

Sparganium stoloniferum

Structure Type

Carbohydrates

Category

SMILES

C(C(C(CO)O)O)O

Synonyms

IUPAC Name

Density

1.4±0.1 g/cm3

Solubility

>6mg/mL in DMSO

Flash Point

208.7±21.1 °C

Boiling Point

330.0±0.0 °C at 760 mmHg

Melting Point

118-120 °C(lit.)

InChl

InChI=1S/C4H10O4/c5-1-3(7)4(8)2-6/h3-8H,1-2H2

InChl Key

UNXHWFMMPAWVPI-UHFFFAOYSA-N

WGK Germany

RID/ADR

HS Code Reference

2905490000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:149-32-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

PMID

32078770

Abstract

Out of 3439 children seen at entry-points, 2107 had an unknown HIV status (61.3%) and HIV testing acceptance rate was 99.9% (2104). Their mean age was 2.1 (Sd鈥=鈥2.96) years, with a sex ratio boy/girl of 6/5. HIV prevalence was 2.1% (44), without a significant difference between boys and girls (p鈥=鈥0.081). High rates of HIV-infection were found among siblings/descendants (22.2%), TB treatment unit attendees (11.4%) and hospitalized children/adolescents (5.6%);聽p鈥<鈥0.001. Up to 95.4% (42/44) of those infected children/adolescents were initiated on ART. Overall, 487 (23.2%) deaths were registered (122 per month) and among them, 7 (15.9%) were HIV-positive; mainly due to tuberculosis and malnutrition.

KEYWORDS

5-(2-hydroxyphenyl)pyrazole; IspD; MEP pathway; analogue; herbicide; pseudilin; synthesis.

Title

Synthesis and Evaluation of Halogenated 5-(2-Hydroxyphenyl)pyrazoles as Pseudilin Analogues Targeting the Enzyme IspD in the Methylerythritol Phosphate Pathway

Author

Jili Wang 1, Yaqing Zhou 1, Xiuwen Wang 1, Lixia Duan 1, Jiang Duan 1, Weiguo Li 1, Aidong Zhang 1

Publish date

2020 Mar 11;

PMID

31879352

Title

Uncovering the functional residues of Arabidopsis isoprenoid biosynthesis enzyme HDS

Author

Jin-Zheng Wang 1, Yongxing Lei 2, Yanmei Xiao 3, Xiang He 1, Jiubo Liang 1, Jishan Jiang 1, Shangzhi Dong 2, Haiyan Ke 1, Patricia Leon 4, Philipp Zerbe 3, Youli Xiao 5, Katayoon Dehesh 6

Publish date

2020 Jan 7

PMID

31792474

Abstract

Purpose: To explore the effect of erythritol on the growth of Porphyromonas gingivalis (Pg), Aggregatibacter actinomycetemcomitans(Aa), Actinomices viscosus (Av), and to explore how Porphyromonas gingivalis affected by erythritol influence mRNA expression level of inflammatory in periodontal cells.

Methods: Pg, Aa, Av were anaerobically cultured (80%N2, 10%CO2, 10%H2) at 37℃ in 2, 4, 8, 16, 32, 64, 128 g/L erythritol- BHI mixture groups (experimental groups) and BHI groups (control group). The lowest erythritol concentration without turbidity or precipitation was the minimum inhibitory concentration. Pg was cultured in MIC, 1/2, 1/4, 1/8 MIC erythritol- BHI mixture groups (experimental groups) and BHI groups (control group). Each kind of bacteria in each concentration group was centrifugalled and cleaned before added into DMEM. The mixed suspension was co-cultured with the periodontal ligament cells in four generations for 24 hours, the supernatan was removed , then the total RNA in cracking cells was extracted and reversing transcription. At last, the relative expression of IL-1, IL-6, TNF-a was detected real-time fluorescent quantitative PCR. The data were analyzed with SPSS19.0 software package.

Results: The minimum inhibitory by concentrations of erythritol on three bacteria were as followed: Pg: 64 g/L,Aa: 128 g/L,Av: 128 g/L. The ability of stimulating periodontal ligament cells to produce IL-1β, IL-6 and TNF-α was different when Pg was cultured under different concentrations of erythritol. There was no significant difference between 0 g/L of control group and 8 g/L of experimental group. As the concentration reached 16 g/L, the relative expression of IL-1β, IL-6, TNF-α was reduced, and the higher concentration was, the less inflammatory factors was. However, the inflammatory factors in all the experimental groups were always significantly higher than that in the blank control group (P<0.05).

Conclusions: Erythritol has an inhibitory effect on the growth of Pg, Aa and Av. In a certain range, higher concentration of erythritol delivers better inhibition effect. Erythritol can also reduce the periodontal pathogenicity of pathogenic bacteria in a way inhibiting the virulence of these bacteria, reducing the production of IL-1β, IL-6, and TNF-a in periodontal cells.

Title

[Antibacterial activity of erythritol on periodontal pathogen]

Author

Jia-Li Zhang 1, Jun Yao, Ji-Na Zhuge, Yan-Jun Zhang

Publish date

2019 Aug


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