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  • Brand : BIOFRON

  • Catalogue Number : BF-E3002

  • Specification : 98%

  • CAS number : 140-67-0

  • Formula : C10H12O

  • Molecular Weight : 148.205

  • PUBCHEM ID : 8815

  • Volume : 100mg

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Catalogue Number


Analysis Method






Molecular Weight



Light yellow liquid

Botanical Source

Pandanus amaryllifolius

Structure Type



Standards;Natural Pytochemical;API




4-allyl-1-methoxybenzene/Anisole, p-allyl-/p-Allyl-Anisole/Tarragon/4-allyl/Estragol/1-Methoxy-4-(2-propen-1-yl)benzene/Estragole/4-Methoxyallylbenzene/Chavicol methyl ether,Estragole/4-MeOC6H4CH2-CH=CH2/Esdragon/methyl chavicol/p-methoxyallylbenzene/Benzene, 1-methoxy-4-(2-propen-1-yl)-/4-Allylmethoxybenzene/para-allylanisole/Terragon/Esdragol/4-Allylphenyl methyl ether/Chavicol methyl ether/Chavicol, O-methyl-/1-Allyl-4-methoxybenzene/1-Methoxy-4-(2-propenyl)benzene/1U2R DO1/4-Allylanisole/Esdragole




0.9±0.1 g/cm3


Flash Point

81.1±0.0 °C

Boiling Point

216.0±0.0 °C at 760 mmHg

Melting Point


InChl Key

WGK Germany


HS Code Reference


Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:140-67-0) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate




Toxoplasmosis is caused by Toxoplasma gondii , an obligatory intracellular protozoan. Normally benign, T. gondii infections can cause devastating disease in immunosuppressed patients and through congenital infection of newborn babies. Few prophylactic and therapeutic drugs are available to treat these infections. The goal of the present study was to assess the anti-Toxoplasma effects in a congenital and noncongenital model of toxoplasmosis (using ME49 strain), besides assessing immunological changes, in vitro cytotoxicity, and in vivo acute toxicity of commercial estragole and thymol. The congenital experimental model was used with intermediate stages of maternal infection. The serum levels of immunoglobulin (Ig)M, IgG, interleukin (IL)-10, IL-12, and interferon-gamma (IFN-γ) were quantified from infected and treated C57Bl/6 mice. Estragole and thymol respectively exhibited low to moderate in vivo toxicity and cytotoxicity. Animals treated with estragole showed high IFN-γ and strong type 1 helper T cell response. Both compounds were active against T. gondii ME49 strain. Furthermore, orally administered estragole in infected pregnant mice improved the weight of offspring compared with untreated controls. Subcutaneous administration of both compounds also increased the weight of mouse offspring born to infected mothers, compared with untreated controls. Estragole and thymol display important anti-Toxoplasma activity. Further studies are needed to elucidate the mechanism of action of these compounds.


Anti-Toxoplasma Activity of Estragole and Thymol in Murine Models of Congenital and Noncongenital Toxoplasmosis


Claudio B S Oliveira 1 , Ywlliane S R Meurer 1 , Thales L Medeiros 1 , Adrian M Pohlit, Murilo V Silva, Tiago W P Mineo, Valter F Andrade-Neto 1

Publish date

2016 Jun




Levels of estragole in fennel teas (n = 42) on the Austrian market and the associated dietary exposure were assessed in this study. The estimated daily exposure from consumption of fennel teas ranged from 0.25 to 5.04 μg kg-1 d-1, 0.32 to 6.42 μg kg-1 d-1, and 0.15 to 2.93 μg kg-1 d-1 for children, women, and men, respectively. Daily estragole exposures for infants were 0.008-20.78 μg kg-1 d-1. Despite MOE values are above 10,000 for nearly half of the fennel teas analyzed, there are still MOEs below this value indicating a potential risk for human health and a priority for risk management. However, fennel teas are generally consumed only for short periods of gastrointestinal disorders. Estimated daily intakes may, therefore, be conservative and tend to overestimate the potential risk for human health.


Estragole; dietary exposure; fennel tea; risk assessment.


Levels of Estragole in Fennel Teas Marketed in Austria and Assessment of Dietary Exposure


Daniela Mihats 1 , Leopold Pilsbacher 2 , Robert Gabernig 3 , Martin Routil 3 , Martin Gutternigg 3 , Reinhard Laenger 4

Publish date

2017 Aug




Estragole, a naturally occurring constituent of various herbs and spices, is a rodent liver carcinogen which requires bio-activation. To further understand the mechanisms underlying its carcinogenicity, genotoxicity was assessed in F344 rats using the comet, micronucleus (MN), and DNA adduct assays together with histopathological analysis. Oxidative damage was measured using human 8-oxoguanine-DNA-N-glycosylase (hOGG1) and EndonucleaseIII (EndoIII)-modified comet assays. Results with estragole were compared with the structurally related genotoxic carcinogen, safrole. Groups of seven-week-old male F344 rats received corn oil or corn oil containing 300, 600, or 1,000 mg/kg bw estragole and 125, 250, or 450 mg/kg bw safrole by gavage at 0, 24, and 45 hr and terminated at 48 hr. Estragole-induced dose-dependent increases in DNA damage following EndoIII or hOGG1 digestion and without enzyme treatment in liver, the cancer target organ. No DNA damage was detected in stomach, the non-target tissue for cancer. No elevation of MN was observed in reticulocytes sampled from peripheral blood. Comet assays, both without digestion or with either EndoIII or hOGG1 digestion, also detected DNA damage in the liver of safrole-dosed rats. No DNA damage was detected in stomach, nor was MN elevated in peripheral blood following dosing with safrole suggesting that, as far both safrole and estragole, oxidative damage may contribute to genotoxicity. Taken together, these results implicate multiple mechanisms of estragole genotoxicity. DNA damage arises from chemical-specific interaction and is also mediated by oxidative species.


In vivo comet assay; cell proliferation; direct DNA damage; inflammation; oxidative DNA damage.


In Vivo Genotoxicity of Estragole in Male F344 Rats


Wei Ding 1 , Dan D Levy, Michelle E Bishop, Mason G Pearce, Kelly J Davis, Alan M Jeffrey, Jian-Dong Duan, Gary M Williams, Gene A White, Lascelles E Lyn-Cook, Mugimane G Manjanatha

Publish date

2015 May

Description :

Estragole (4-Allylanisole), a relatively nontoxic volatile terpenoid ether, is a major component of the essential oil of many plants. Estragole has potent local anesthetic activity and dose-dependently blocks nerve excitability[1]. Estragole displays anti-toxoplasma activity[2].