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Ethanolamine O-phosphate

$43

  • Brand : BIOFRON

  • Catalogue Number : BF-E3001

  • Specification : 95%

  • CAS number : 1071-23-4

  • Formula : C2H8NO4P

  • Molecular Weight : 141.063

  • Volume : 100mg

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Catalogue Number

BF-E3001

Analysis Method

HPLC,NMR,MS

Specification

95%

Storage

2-8°C

Molecular Weight

141.063

Appearance

powder

Botanical Source

Proteus mirabilis

Structure Type

Others

Category

SMILES

NCCO[P](O)(O)=O

Synonyms

IUPAC Name

Density

1.554g/cm3

Solubility

H2O : 250 mg/mL (1772.30 mM; Need ultrasonic)

Flash Point

156.9ºC

Boiling Point

335.8ºC at 760mmHg

Melting Point

241-243 °C(lit.)

InChl

InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)

InChl Key

SUHOOTKUPISOBE-UHFFFAOYSA-N

WGK Germany

RID/ADR

HS Code Reference

2921190000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:1071-23-4) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

PMID

31657926

Abstract

EPA-enriched phosphoethanolamine plasmalogens (EPA-pPE), widely present in marine creatures, is a unique glycerophospholipid with EPA at the sn-2 position of the glycerol backbone. EPA-pPE has been reported to exhibit numerous distinctive bioactivities. However, the digestion, absorption, and metabolism characteristics of EPA-pPE in vivo are not clear, which restrict the molecular mechanism analysis related to its distinctive activities. The aim of the present study was to illustrate the digestion, absorption, and metabolism characteristics of EPA-pPE by lipid analysis in serum, intestinal wall, and content after oral administration of EPA-pPE emulsion. Results showed the EPA percentage of total fatty acids in serum was increasing over time, with two peaks at 5 and 10 h by 1.89 ± 0.2 and 2.58 ± 0.27, respectively, and then fell from 1.89 ± 0.17 at 10 h to 1.35 ± 0.16 at 16 h. In small intestinal content, EPA-pPE was hydrolyzed to lyso-phospholipids and EPA by phospholipases A2 and the vinyl ether bond was retained at the sn-1 position. The released EPA could be quickly taken up into the enterocytes and enter circulation. The comparison of simulated digestion in vitro showed that the distinct digestion and absorption process of EPA-pPE was a unique phenomenon. EPA could be retained in serum at a high level for a substantial period of time, which suggested that EPA-pPE was not just a short-lived circulating molecule.

KEYWORDS

absorption; digestion; ethanolamine plasmalogens; lipidomics analysis; metabolism.

Title

Digestion, Absorption, and Metabolism Characteristics of EPA-Enriched Phosphoethanolamine Plasmalogens Based on Gastrointestinal Functions in Healthy Mice

Author

Teng Wang 1, Pei-Xu Cong 1, Jie Cui 1, Shan Jiang 1, Jie Xu 1, Chang-Hu Xue 1 2, Qing-Rong Huang 3, Tian-Tian Zhang 1, Yu-Ming Wang 1 2

Publish date

2019 Nov 20

PMID

31504580

Title

Detection of a novel mcr-5.4 gene variant in hospital tap water by shotgun metagenomic sequencing

Author

Giuseppe Fleres 1, Natacha Couto 1, Leonard Schuele 1, Monika A Chlebowicz 1, Catarina I Mendes 1, Luc W M van der Sluis 2, John W A Rossen 1, Alex W Friedrich 1, Silvia Garcia-Cobos 1

Publish date

2019 Dec 1;

PMID

31325159

Abstract

Structural diversity of natural cobamides (Cbas, B12 vitamers) is limited to the nucleotide loop. The loop is connected to the cobalt-containing corrin ring via an (R)-1-aminopropan-2-ol O-2-phosphate (AP-P) linker moiety. AP-P is produced by the l-threonine O-3-phosphate (l-Thr-P) decarboxylase CobD. Here, the CobD homolog SMUL_1544 of the organohalide-respiring epsilonproteobacterium Sulfurospirillum multivorans was characterized as a decarboxylase that produces ethanolamine O-phosphate (EA-P) from l-serine O-phosphate (l-Ser-P). EA-P is assumed to serve as precursor of the linker moiety of norcobamides that function as cofactors in the respiratory reductive dehalogenase. SMUL_1544 (SmCobD) is a pyridoxal-5′-phosphate (PLP)-containing enzyme. The structural analysis of the SmCobD apoprotein combined with the characterization of truncated mutant proteins uncovered a role of the SmCobD N-terminus in efficient l-Ser-P conversion.

KEYWORDS

cobamides; ethanolamine phosphate; norcobamide biosynthesis; serine phosphate decarboxylase.

Title

Structural and functional analysis of an l-serine O-phosphate decarboxylase involved in norcobamide biosynthesis

Author

Sebastian Keller 1, Karl M Wetterhorn 2, Alison Vecellio 2, Mark Seeger 2, Ivan Rayment 2, Torsten Schubert 1

Publish date

2019 Nov


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