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provides coniferyl ferulate(CAS#:1071-23-4) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate
EPA-enriched phosphoethanolamine plasmalogens (EPA-pPE), widely present in marine creatures, is a unique glycerophospholipid with EPA at the sn-2 position of the glycerol backbone. EPA-pPE has been reported to exhibit numerous distinctive bioactivities. However, the digestion, absorption, and metabolism characteristics of EPA-pPE in vivo are not clear, which restrict the molecular mechanism analysis related to its distinctive activities. The aim of the present study was to illustrate the digestion, absorption, and metabolism characteristics of EPA-pPE by lipid analysis in serum, intestinal wall, and content after oral administration of EPA-pPE emulsion. Results showed the EPA percentage of total fatty acids in serum was increasing over time, with two peaks at 5 and 10 h by 1.89 ± 0.2 and 2.58 ± 0.27, respectively, and then fell from 1.89 ± 0.17 at 10 h to 1.35 ± 0.16 at 16 h. In small intestinal content, EPA-pPE was hydrolyzed to lyso-phospholipids and EPA by phospholipases A2 and the vinyl ether bond was retained at the sn-1 position. The released EPA could be quickly taken up into the enterocytes and enter circulation. The comparison of simulated digestion in vitro showed that the distinct digestion and absorption process of EPA-pPE was a unique phenomenon. EPA could be retained in serum at a high level for a substantial period of time, which suggested that EPA-pPE was not just a short-lived circulating molecule.
absorption; digestion; ethanolamine plasmalogens; lipidomics analysis; metabolism.
Digestion, Absorption, and Metabolism Characteristics of EPA-Enriched Phosphoethanolamine Plasmalogens Based on Gastrointestinal Functions in Healthy Mice
Teng Wang 1, Pei-Xu Cong 1, Jie Cui 1, Shan Jiang 1, Jie Xu 1, Chang-Hu Xue 1 2, Qing-Rong Huang 3, Tian-Tian Zhang 1, Yu-Ming Wang 1 2
2019 Nov 20
Detection of a novel mcr-5.4 gene variant in hospital tap water by shotgun metagenomic sequencing
Giuseppe Fleres 1, Natacha Couto 1, Leonard Schuele 1, Monika A Chlebowicz 1, Catarina I Mendes 1, Luc W M van der Sluis 2, John W A Rossen 1, Alex W Friedrich 1, Silvia Garcia-Cobos 1
2019 Dec 1;
Structural diversity of natural cobamides (Cbas, B12 vitamers) is limited to the nucleotide loop. The loop is connected to the cobalt-containing corrin ring via an (R)-1-aminopropan-2-ol O-2-phosphate (AP-P) linker moiety. AP-P is produced by the l-threonine O-3-phosphate (l-Thr-P) decarboxylase CobD. Here, the CobD homolog SMUL_1544 of the organohalide-respiring epsilonproteobacterium Sulfurospirillum multivorans was characterized as a decarboxylase that produces ethanolamine O-phosphate (EA-P) from l-serine O-phosphate (l-Ser-P). EA-P is assumed to serve as precursor of the linker moiety of norcobamides that function as cofactors in the respiratory reductive dehalogenase. SMUL_1544 (SmCobD) is a pyridoxal-5′-phosphate (PLP)-containing enzyme. The structural analysis of the SmCobD apoprotein combined with the characterization of truncated mutant proteins uncovered a role of the SmCobD N-terminus in efficient l-Ser-P conversion.
cobamides; ethanolamine phosphate; norcobamide biosynthesis; serine phosphate decarboxylase.
Structural and functional analysis of an l-serine O-phosphate decarboxylase involved in norcobamide biosynthesis
Sebastian Keller 1, Karl M Wetterhorn 2, Alison Vecellio 2, Mark Seeger 2, Ivan Rayment 2, Torsten Schubert 1