Catalogue Number
BN-O1640
Analysis Method
HPLC,NMR,MS
Specification
99%(HPLC)
Storage
-20℃
Molecular Weight
347.4
Appearance
Powder
Botanical Source
This product is isolated and purified from the herbs of Skimmia reevesiana Fort.
Structure Type
Alkaloids
Category
Standards;Natural Pytochemical;API
SMILES
CC(C)(C(COC1=C(C2=C(C=C1)C(=C3C=COC3=N2)OC)OC)O)O
Synonyms
Evoxin,Haploperine/(+)-1-((4,8-Dimethoxyfuro(2,3-b)quinolin-7-yl)oxy)-3-methyl-2,3-butanediol/Haploperine/2,3-Butanediol, 1-[(4,8-dimethoxyfuro[2,3-b]quinolin-7-yl)oxy]-3-methyl-/1-[(4,8-dimethoxyfuro[2,3-b]quinolin-7-yl)oxy]-3-methylbutane-2,3-diol/1-[(4,8-Dimethoxyfuro[2,3-b]quinolin-7-yl)oxy]-3-methyl-2,3-butanediol/2,3-Butanediol, 1-((4,8-dimethoxyfuro(2,3-b)quinolin-7-yl)oxy)-3-methyl-, (+)-/Evoxine/2,3-Butanediol, 1-[(4,8-dimethoxyfuro[2,3-b]quinolin-7-yl)oxy]-3-methyl-, (+)-
IUPAC Name
1-(4,8-dimethoxyfuro[2,3-b]quinolin-7-yl)oxy-3-methylbutane-2,3-diol
Density
1.3±0.1 g/cm3
Solubility
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Flash Point
283.9±28.7 °C
Boiling Point
545.9±45.0 °C at 760 mmHg
Melting Point
InChl
InChI=1S/C18H21NO6/c1-18(2,21)13(20)9-25-12-6-5-10-14(16(12)23-4)19-17-11(7-8-24-17)15(10)22-3/h5-8,13,20-21H,9H2,1-4H3
InChl Key
FGANMDNHTVJAHL-UHFFFAOYSA-N
WGK Germany
RID/ADR
HS Code Reference
2933990000
Personal Projective Equipment
Correct Usage
For Reference Standard and R&D, Not for Human Use Directly.
Meta Tag
provides coniferyl ferulate(CAS#:522-11-2) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate
No Technical Documents Available For This Product.
26701099
Patients with severe lung disease may develop hypercapnia, elevation of the levels of CO2 in the lungs and blood, which is associated with increased risk of death, often from infection. To identify compounds that ameliorate the adverse effects of hypercapnia, we performed a focused screen of 8832 compounds using a CO2-responsive luciferase reporter in Drosophila S2* cells. We found that evoxine, a plant alkaloid, counteracts the CO2-induced transcriptional suppression of antimicrobial peptides in S2* cells. Strikingly, evoxine also inhibits hypercapnic suppression of interleukin-6 and the chemokine CCL2 expression in human THP-1 macrophages. Evoxine’s effects are selective, since it does not prevent hypercapnic inhibition of phagocytosis by THP-1 cells or CO2-induced activation of AMPK in rat ATII pulmonary epithelial cells. The results suggest that hypercapnia suppresses innate immune gene expression by definable pathways that are evolutionarily conserved and demonstrate for the first time that specific CO2 effects can be targeted pharmacologically.
© 2015 Society for Laboratory Automation and Screening.
anti-infective drugs; cell-based assays; immune system diseases; reporter gene assays
Focused Screening Identifies Evoxine as a Small Molecule That Counteracts CO2-Induced Immune Suppression.
Helenius IT1, Nair A2, Bittar HE2, Sznajder JI2, Sporn PH3, Beitel GJ4
2016 Apr
