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Fagarine

$390

  • Brand : BIOFRON

  • Catalogue Number : AV-H25198

  • Specification : 98%

  • CAS number : 524-15-2

  • Formula : C13H11NO3

  • Molecular Weight : 229.24

  • PUBCHEM ID : 107936

  • Volume : 10mg

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Catalogue Number

AV-H25198

Analysis Method

HPLC,NMR,MS

Specification

98%

Storage

2-8°C

Molecular Weight

229.24

Appearance

White crystalline powder

Botanical Source

Structure Type

Alkaloids

Category

Standards;Natural Pytochemical;API

SMILES

COC1=CC=CC2=C1N=C3C(=C2OC)C=CO3

Synonyms

8-Methoxydictamine/8-Methoxydictamnine/4,8-Dimethoxyfuro[2,3-b]quinoline/Fagarine/Furo[2,3-b]quinoline, 4,8-dimethoxy-/g-fagarine/γ-Fagarine

IUPAC Name

4,8-dimethoxyfuro[2,3-b]quinoline

Applications

Density

1.3±0.1 g/cm3

Solubility

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

Flash Point

184.2±26.5 °C

Boiling Point

381.0±37.0 °C at 760 mmHg

Melting Point

142°

InChl

InChI=1S/C13H11NO3/c1-15-10-5-3-4-8-11(10)14-13-9(6-7-17-13)12(8)16-2/h3-7H,1-2H3

InChl Key

KFBCTNNQFGONHB-UHFFFAOYSA-N

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:524-15-2) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

19296377

Abstract

Leaves and wood of Peltostigma guatemalense, a novel species of the family Rutaceae, yielded a total of 14 secondary metabolites, i.e. methyl p-hydroxy benzoate, phenylacetic acid, beta-sitosterol, lupeol, syringaresinol, scopoletin, gardenin B (1), and seven alkaloids: gamma-fagarine (2), skimmianine (3), kokusaginine (4), 7-O-isopentenyl-gamma-fagarine (5), anhydro-evoxine (6), evoxine (7) and 4-methoxy-1-methyl-quinolin-2-one (8). The compounds have been identified by spectroscopic methods. Antibacterial and antimalarial in vitro activity of the isolated compounds were also determined. Methyl p-hydroxy benzoate and quinolone (8) were the most effective on Plasmodium falciparium strains.

Title

Biological activity of secondary metabolites from Peltostigma guatemalense.

Author

Cuca Suarez LE1, Pattarroyo ME, Lozano JM, Delle Monache F.

Publish date

2009

PMID

18080680

Abstract

This study aimed to evaluate the in vitro and in vivo leishmanicidal activity of an endemic Turkish plant and compare its efficacy with a reference drug. In addition to the in vitro activities of the ethanol, acidified and alkaloid extracts and furoquinoline alkaloids skimmianine and gamma-fagarine, in vivo antileishmanial activitiy of the acidified extract of Haplophyllum myrtifolium Boiss. (Rutaceae) were investigated against Leishmania tropica (L. tropica), a causative agent of cutaneous leishmaniasis. All the extracts and pure compounds showed in vitro inhibitory activity against the promastigotes of. L. tropica. The in vitro 50% inhibitory concentrations of y-fagarine, acidified extract, ethanol extract, skimmianine and alkaloid extract against promastigotes were determined as 8.7, 9.4, 10.9, 25.7 and 25.8 microg/ml respectively. In vivo results of Haplophyllum myrtifolium acidified extract showed that this plant has a limited effect on decreasing the lesion size of experimental mice infected with Leishmania tropica. To the best of our knowledge, this is the first time both the in vitro and in vivo antileishmanial activity of Haplophyllum mrytifolium have been reported in the same research.

Title

In vitro and in vivo activities of Haplophyllum myrtifolium against Leishmania tropica.

Author

Ostan I1, Saglam H, Limoncu ME, Ertabaklar H, Toz SO, Ozbel Y, Ozbilgin A.

Publish date

2007 Oct;

PMID

18052337

Abstract

The study aimed to elucidate the effects of benzothiadiazole (BTH) and saccharin on the biosynthesis of simple coumarins, linear furanocoumarins, dihydrofuranocoumarins, and furoquinolone alkaloids in shoots of R. graveolens cultivated in vitro. The biosynthesized metabolites were analyzed and identified by GC-MS and by comparison of Kovats indices. Eight coumarin metabolites were identified: bergapten, chalepin, isopimpinelin, pinnarin, psoralen, rutacultin, rutamarin, and xanthotoxin, and also four alkaloids: dictamnine, gamma-fagarine, skimmianine, and kokusaginine. Each of the tested BTH concentrations induced a significant production of furanocoumarins and furoquinolone alkaloids. The use of saccharin also increased the production of bergapten, isopimpinelin, pinnarin, psoralen, and xanthotoxin several times.

Title

Identification of Ruta graveolens L. metabolites accumulated in the presence of abiotic elicitors.

Author

Orlita A1, Sidwa-Gorycka M, Kumirska J, Mali?ski E, Siedlecka EM, Gajdus J, Lojkowska E, Stepnowski P.

Publish date

2008 Jan-Feb;