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Falcarindiol

$560

Brand : BIOFRON
Catalogue Number : BD-P0003
Specification : 98.0%(HPLC)
CAS number : 225110-25-8
Formula : C17H24O2
Molecular Weight : 260.4
PUBCHEM ID : 5281148
Volume : 0.1ml

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Catalogue Number

BD-P0003

Analysis Method

Specification

98.0%(HPLC)

Storage

-20℃

Molecular Weight

260.4

Appearance

Oil

Botanical Source

This product is isolated and purified from the roots of Angelica sinensis

Structure Type

Category

SMILES

CCCCCCCC=CC(C#CC#CC(C=C)O)O

Synonyms

(3R,8S,9Z)-heptadeca-1,9-dien-4,6-diyne-3,8-diol

IUPAC Name

Density

1.0±0.1 g/cm3

Solubility

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

Flash Point

184.7±23.3 °C

Boiling Point

408.2±45.0 °C at 760 mmHg

Melting Point

InChl

InChl Key

QWCNQXNAFCBLLV-YWALDVPYSA-N

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:225110-25-8) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

28362800

Abstract

Toxoplasmosis is a zoonotic infection affecting approximately 30% of the world’s human population. After sexual reproduction in the definitive feline host, Toxoplasma oocysts, each containing 8 sporozoites, are shed into the environment where they can go on to infect humans and other warm-blooded intermediate hosts. Here, we use an in vitro model to assess host transcriptomic changes that occur in the earliest stages of such infections. We show that infection of rat intestinal epithelial cells with mature sporozoites primarily results in higher expression of genes associated with Tumor Necrosis Factor alpha (TNFα) signaling via NF-κB. Furthermore, we find that, consistent with their biology, these mature, invaded sporozoites display a transcriptome intermediate between the previously reported day 10 oocysts and that of their tachyzoite counterparts. Thus, this study uncovers novel host and pathogen factors that may be critical for the establishment of a successful intracellular niche following sporozoite-initiated infection.

Title

An in vitro model of intestinal infection reveals a developmentally regulated transcriptome of Toxoplasma sporozoites and a NF-κB-like signature in infected host cells

Author

Pascale S. Guiton,1

Publish date

2017

PMID

16870616

Abstract

Carnitine acyltransferases catalyze the reversible exchange of acyl groups between coenzyme A (CoA) and carnitine. They have important roles in many cellular processes, especially the oxidation of long-chain fatty acids in the mitochondria for energy production, and are attractive targets for drug discovery against diabetes and obesity. To help define in molecular detail the catalytic mechanism of these enzymes, we report here the high resolution crystal structure of wild-type murine carnitine acetyltransferase (CrAT) in a ternary complex with its substrates acetyl-CoA and carnitine, and the structure of the S554A/M564G double mutant in a ternary complex with the substrates CoA and hexanoylcarnitine. Detailed analyses suggest these structures may be good mimics for the Michaelis complexes for the forward and reverse reactions of the enzyme, representing the first time that such complexes of CrAT have been studied in molecular detail. The structural information provides significant new insights into the catalytic mechanism of CrAT and possibly carnitine acyltransferases in general.

Title

Crystal structures of murine carnitine acetyltransferase in ternary complexes with its substrates

Author

Yu-Shan Hsiao, Gerwald Jogl,1 and Liang Tong

Publish date

2010 Sep 16