This product is isolated and purified from the rhizomes of Ferula sinkiangensis K.M.Shen
DMSO : 100 mg/mL (514.99 mM; Need ultrasonic)
372.3±27.0 °C at 760 mmHg
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For Reference Standard and R&D, Not for Human Use Directly.
provides coniferyl ferulate(CAS#:1135-24-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate
During the development of artificial red blood cell (RBC) substitutes, oxidation side reaction is one of the major factors that hinder the application of haemoglobin (Hb)-based oxygen carriers (HBOCs). In order to avoid oxidation toxicity, we designed and prepared natural Hb conjugated with ferulic acid (FA) via simple chemical modification. In addition, the thiol groups on Hb surface were increased via the reaction of Hb with 2-iminothiolane (2-IT) and then modified with FA for the study of anti-oxidant ability. It was showed that Hb modified with FA (FA-Hb) had similar oxygen-binding capacity to natural Hb. Moreover, the anti-oxidant ability of FA-Hb in vitro in different systems was superior to natural Hb and in proportion to the degree of modification of FA. The results indicate that FA-Hb might have the potential to serve as a novel oxygen carrier with the capacity to reduce oxidative side reaction.
2-iminothiolane; Haemoglobin-based oxygen carriers; anti-oxidation; ferulic acid; methaemoglobin.
Ferulic Acid Modification Enhances the Anti-Oxidation Activity of Natural Hb in Vitro
Donglai Qi 1 , Qian Li 1 , Chen Chen 1 , Xiang Wang 1
Ferulic acid is a cinnamic derivative of phenolic acid and its pharmacophore (catechol) is responsible for antioxidant, prooxidant and antibacterial activities. In this study, we evaluated the influence of ferulic acid on the antibacterial activity of quinolone-based antibiotics against Acinetobacter baumannii. The minimum inhibitory concentration of ferulic acid against Acinetobacter baumannii AB5075 were considerably lowered for ΔsodB and ΔkatG mutants. Checkerboard assay shows synergistic interactions between ferulic acid and quinolones. In a murine sepsis model, ferulic acid potentiated the antibacterial activities of quinolones. Ferulic acid amplified quinolones-induced redox imbalance by increasing superoxide ion generation, NAD+/NADH ratio and ADP/ATP ratio. Conversely, the level of reduced glutathione was significantly lowered. We conclude that ferulic acid potentiates the antibacterial activity of quinolone-based antibiotics against A. baumannii by increasing ROS generation, energy metabolism and electron transport chain activity with a concomitant decrease in glutathione.
Acinetobacter baumannii; Catalase; Electron transport; Ferulic acid; Glutathione; Superoxide dismutase.
Ferulic Acid Potentiates the Antibacterial Activity of Quinolone-Based Antibiotics Against Acinetobacter Baumannii
O B Ibitoye 1 , T O Ajiboye 2
Oxidative stress plays an important role in both initiation and progression of neurodegenerative diseases, such as Alzheimer and Parkinson. Therefore, much attention has been paid to antioxidants for developing therapeutic strategies for the neurodegenerative diseases. However, as serious adverse effects are related to synthetic antioxidants, recent research has been focused on natural products especially phenolic antioxidants. In the present article, we critically review the available literature related to the beneficial role of ferulic acid on Alzheimer’s disease, since it is a natural antioxidant which is widely found in different fruits and vegetables. We also provide some informations about sources, chemical structure, bioavailability and clinical impacts of ferulic acid.
Ferulic Acid and Alzheimer's Disease: Promises and Pitfalls
Seyed Fazel Nabavi, Kasi Pandima Devi 1 , Dicson Sheeja Malar, Antoni Sureda, Maria Daglia, Seyed Mohammad Nabavi
Crit Rev Biotechnol. 2004;24(2-3):59-83. Ferulic acid: an antioxidant found naturally in plant cell walls and feruloyl esterases involved in its release and their applications.[Pubmed: 15493526 ]Ferulic acid is the most abundant hydroxycinnamic acid in the plant world and maize bran with 3.1% (w/w) Ferulic acid is one of the most promising sources of this antioxidant. METHODS AND RESULTS:The dehydrodimers of Ferulic acid are important structural components in the plant cell wall and serve to enhance its rigidity and strength. Feruloyl esterases are a subclass of the carboxylic acid esterases that hydrolyze the ester bond between hydroxycinnamic acids and sugars present in plant cell walls and they have been isolated from a wide range of microorganisms, when grown on complex substrates such as cereal brans, sugar beet pulp, pectin and xylan. These enzymes perform a function similar to alkali in the deesterification of plant cell wall and differ in their specificities towards the methyl esters of cinnamic acids and ferulolylated oligosaccharides. They act synergistically with xylanases and pectinases and facilitate the access of hydrolases to the backbone of cell wall polymers. CONCLUSIONS:The applications of Ferulic acid and feruloyl esterase enzymes are many and varied. Ferulic acid obtained from agricultural byproducts is a potential precursor for the production of natural vanillin, due to the lower production cost.