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Fisetin

$78

  • Brand : BIOFRON

  • Catalogue Number : BF-F3006

  • Specification : 98%

  • CAS number : 528-48-3

  • Formula : C15H10O6

  • Molecular Weight : 286.24

  • PUBCHEM ID : 5281614

  • Volume : 25mg

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Catalogue Number

BF-F3006

Analysis Method

HPLC,NMR,MS

Specification

98%

Storage

-20℃

Molecular Weight

286.24

Appearance

Light yellow crystalline powder

Botanical Source

Glycyrrhiza uralensis,Cotinus coggygria,Rosa bracteata,Toxicodendron vernicifluum

Structure Type

Flavonoids

Category

Standards;Natural Pytochemical;API

SMILES

C1=CC(=C(C=C1C2=C(C(=O)C3=C(O2)C=C(C=C3)O)O)O)O

Synonyms

5-Deoxyquercetin/4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-3,7-dihydroxy-/Fisetin/Viset/3,3',4',7-tetrahydroxyflavone/Fustet/Superfustel/Cotinin/Fustel/Fisidenolon 1521/5-Desoxyquercetin/3,7-Dihydroxy-2-(3,4-dihydroxyphenyl)-4H-1-benzopyran-4-one/2-(3,4-Dihydroxyphenyl)-3,7-dihydroxy-4H-chromen-4-one/2-(3,4-dihydroxyphenyl)-3,7-dihydroxychromen-4-one/Fietin/3,7,3',4'-Tetrahydroxyflavone/Fisetholz

IUPAC Name

2-(3,4-dihydroxyphenyl)-3,7-dihydroxychromen-4-one

Density

1.7±0.1 g/cm3

Solubility

Methanol

Flash Point

233.0±23.6 °C

Boiling Point

599.4±50.0 °C at 760 mmHg

Melting Point

330ºC

InChl

InChl Key

WGK Germany

RID/ADR

HS Code Reference

2932990000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:528-48-3) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

PMID

30279143

Abstract

BACKGROUND:
Senescence is a tumor suppressor mechanism activated in stressed cells to prevent replication of damaged DNA. Senescent cells have been demonstrated to play a causal role in driving aging and age-related diseases using genetic and pharmacologic approaches. We previously demonstrated that the combination of dasatinib and the flavonoid quercetin is a potent senolytic improving numerous age-related conditions including frailty, osteoporosis and cardiovascular disease. The goal of this study was to identify flavonoids with more potent senolytic activity.

METHODS:
A panel of flavonoid polyphenols was screened for senolytic activity using senescent murine and human fibroblasts, driven by oxidative and genotoxic stress, respectively. The top senotherapeutic flavonoid was tested in mice modeling a progeroid syndrome carrying a p16INK4a-luciferase reporter and aged wild-type mice to determine the effects of fisetin on senescence markers, age-related histopathology, disease markers, health span and lifespan. Human adipose tissue explants were used to determine if results translated.

FINDINGS:
Of the 10 flavonoids tested, fisetin was the most potent senolytic. Acute or intermittent treatment of progeroid and old mice with fisetin reduced senescence markers in multiple tissues, consistent with a hit-and-run senolytic mechanism. Fisetin reduced senescence in a subset of cells in murine and human adipose tissue, demonstrating cell-type specificity. Administration of fisetin to wild-type mice late in life restored tissue homeostasis, reduced age-related pathology, and extended median and maximum lifespan.

INTERPRETATION:
The natural product fisetin has senotherapeutic activity in mice and in human tissues. Late life intervention was sufficient to yield a potent health benefit. These characteristics suggest the feasibility to translation to human clinical studies. FUND: NIH grants P01 AG043376 (PDR, LJN), U19 AG056278 (PDR, LJN, WLL), R24 AG047115 (WLL), R37 AG013925 (JLK), R21 AG047984 (JLK), P30 DK050456 (Adipocyte Subcore, JLK), a Glenn Foundation/American Federation for Aging Research (AFAR) BIG Award (JLK), Glenn/AFAR (LJN, CEB), the Ted Nash Long Life and Noaber Foundations (JLK), the Connor Group (JLK), Robert J. and Theresa W. Ryan (JLK), and a Minnesota Partnership Grant (AMAY-UMN#99)-P004610401-1 (JLK, EAA).

Copyright © 2018 The Authors. Published by Elsevier B.V. All rights reserved.

KEYWORDS

Aging; Healthspan; Lifespan; Progeria; Senescence; Senolytic

Title

Fisetin is a senotherapeutic that extends health and lifespan.

Author

Yousefzadeh MJ1, Zhu Y2, McGowan SJ1, Angelini L1, Fuhrmann-Stroissnigg H1, Xu M2, Ling YY1, Melos KI1, Pirtskhalava T2, Inman CL2, McGuckian C1, Wade EA1, Kato JI1, Grassi D1, Wentworth M3, Burd CE4, Arriaga EA5, Ladiges WL6, Tchkonia T2, Kirkland JL2, Robbins PD7, Niedernhofer LJ8.

Publish date

2018 Oct

PMID

27671819

Abstract

Chronic inflammation is a prolonged and dysregulated immune response leading to a wide variety of physiological and pathological conditions such as neurological abnormalities, cardiovascular diseases, diabetes, obesity, pulmonary diseases, immunological diseases, cancers, and other life-threatening conditions. Therefore, inhibition of persistent inflammation will reduce the risk of inflammation-associated chronic diseases. Inflammation-related chronic diseases require chronic treatment without side effects. Use of traditional medicines and restricted diet has been utilized by mankind for ages to prevent or treat several chronic diseases. Bioactive dietary agents or “Nutraceuticals” present in several fruits, vegetables, legumes, cereals, fibers, and certain spices have shown potential to inhibit or reverse the inflammatory responses and several chronic diseases related to chronic inflammation. Due to safe, nontoxic, and preventive benefits, the use of nutraceuticals as dietary supplements or functional foods has increased in the Western world. Fisetin (3,3′,4′,7-tetrahydroxyflavone) is a dietary flavonoid found in various fruits (strawberries, apples, mangoes, persimmons, kiwis, and grapes), vegetables (tomatoes, onions, and cucumbers), nuts, and wine that has shown strong anti-inflammatory, anti-oxidant, anti-tumorigenic, anti-invasive, anti-angiogenic, anti-diabetic, neuroprotective, and cardioprotective effects in cell culture and in animal models relevant to human diseases. In this chapter, we discuss the beneficial pharmacological effects of fisetin against different pathological conditions with special emphasis on diseases related to chronic inflammatory conditions.

KEYWORDS

Allergy; Cancer; Cardiovascular diseases; Chronic diseases; Cytokines; Diabetes; Fisetin; Inflammation; Neurological diseases; Nutraceuticals; Obesity; Pulmonary diseases; Transcription factors

Title

Fisetin and Its Role in Chronic Diseases.

Author

Pal HC1, Pearlman RL1, Afaq F2,3.

Publish date

2016

PMID

29225112

Abstract

A wide variety of chronic diseases, such as neurodegenerative and cardiovascular disorders, diabetes mellitus, osteoarthtitis, obesity and various cancers, are now being treated with cost effective phytomedicines. Since synthetic medicines are very expensive, concerted efforts are being made in developing and poor countries to discover cost effective medicines for the treatment of non-communicable diseases (NCDs). Understanding the underlying mechanisms of bioactive medicines from natural sources would not only open incipient avenues for the scientific community and pharmaceutical industry to discover new drug molecules for the therapy of NCDs, but also help to garner knowledge for alternative therapeutic approaches for the management of chronic diseases. Fisetin is a polyphenolic molecule of flavonoids class, and belongs to the bioactive phytochemicals that have potential to block multiple signaling pathways associated with NCDs such as cell division, angiogenesis, metastasis, oxidative stress, and inflammation. The emerging evidence suggests that fisetin may be useful for the prevention and management of several types of human malignancies. Efforts are being made to enhance the bioavailability of fisetin after oral administration to prevent and/or treat cancer of the liver, breast, ovary and other organs. The intent of this review is to highlight the in vitro and in vivo activities of fisetin and to provide up-to-date information about the molecular interactions of fisetin with its cellular targets involved in cancer initiation, promotion and progression as well as to focus on strategies underway to increase the bioavailability and reduce the risk of deleterious effects, if any, associated with fisetin administration.

Copyright © 2017 Elsevier Inc. All rights reserved.

KEYWORDS

Adverse effects; Anticancer properties; Bioavailability; Biosynthesis; Fisetin

Title

Fisetin: A bioactive phytochemical with potential for cancer prevention and pharmacotherapy.

Author

Kashyap D1, Sharma A2, Sak K3, Tuli HS4, Buttar HS5, Bishayee A6.

Publish date

2018 Feb 1


Description :

Fisetin is a natural flavonol found in many fruits and vegetables with various benefits, such as antioxidant, anticancer, neuroprotection effects.