Shipping to France We Offer Worldwide Shipping
Login Wishlist

Forskolin

$93

  • Brand : BIOFRON

  • Catalogue Number : BF-F4001

  • Specification : 98%(HPLC)

  • CAS number : 66575-29-9

  • Formula : C22H34O7

  • Molecular Weight : 410.5

  • PUBCHEM ID : 47936

  • Volume : 20mg

In stock

Quantity
Checkout Bulk Order?

Catalogue Number

BF-F4001

Analysis Method

HPLC,NMR,MS

Specification

98%(HPLC)

Storage

2-8°C

Molecular Weight

410.5

Appearance

White crystalline powder

Botanical Source

herbs of Coleus forskohlii

Structure Type

Terpenoids

Category

Standards;Natural Pytochemical;API

SMILES

CC(=O)OC1C(C2C(CCC(C2(C3(C1(OC(CC3=O)(C)C=C)C)O)C)O)(C)C)O

Synonyms

(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-6,10,10b-Trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-3-vinyldodecahydro-1H-benzo[f]chromen-5-yl acetate/(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-3-ethenyl-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxododecahydro-1H-benzo[f]chromen-5-yl acetate/HL 362/(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-6,10,10b-Trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-3-vinyldodecahydro-1H-benzo[f]chromen-5-ylacetat/Coleonol/1H-Naphtho[2,1-b]pyran-1-one, 5-(acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-, (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-/L 75-1362B/Forskolin/ForsLean/FORSKOHLIN/boforsin/[3H]-Forskolin/COLFORSIN

IUPAC Name

[(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-3-ethenyl-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-5,6,6a,8,9,10-hexahydro-2H-benzo[f]chromen-5-yl] acetate

Applications

Forskolin is a potent adenylate cyclase activator, with IC50 and EC50 of 41 nM and 0.5 μM for type I adenylyl cyclase, respectively.

Density

1.2±0.1 g/cm3

Solubility

Methanol; Chloroform

Flash Point

171.8±23.6 °C

Boiling Point

519.9±50.0 °C at 760 mmHg

Melting Point

282-232ºC

InChl

InChl Key

WGK Germany

RID/ADR

HS Code Reference

2932990000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:66575-29-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

PMID

29902441

Title

Gut Microbiota Produced Tryptamine Activates an Epithelial G-protein Coupled Receptor to Increase Colonic Secretion

Author

Yogesh Bhattarai,1 Brianna B. Williams,2 Eric J. Battaglioli,1 Weston R. Whitaker,3 Lisa Till,4 Madhusudan Grover,1,4 David R. Linden,4 Yasutada Akiba,5,6,7 Karunya K. Kandimalla,8 Nicholas C. Zachos,9 Jonathan D. Kaunitz,5,6,7,10 Justin L. Sonnenburg,3 Michael A. Fischbach,2 Gianrico Farrugia,1,4,11 and Purna C. Kashyap1,4,*

Publish date

2019 Jun 13

PMID

31484301

Abstract

The G-protein-coupled receptor (GPCR) regulated intracellular signaling pathway is known to be involved in the development of insecticide resistance in the mosquito, Culex quinquefasciatus. To elucidate the specific role of each effector in the GPCR regulating pathway, we initially expressed a GPCR, G-protein alpha subunit (Gαs), adenylate cyclase (AC), and protein kinase A (PKA) in insect Spodoptera frugiperda (Sf9) cells and investigated their regulation function on cyclic AMP (cAMP) production and PKA activity. GPCR, Gαs, and AC individually expressed Sf9 cells showed higher cAMP production as the expression of each effector increased. All the effector-expressed cell lines showed increased PKA activity however. Moreover, Sf9 cytochrome P450 gene expression and cell tolerance to permethrin were examined. The relative expression of CYP9A32gene in Sf9 cells tested was significantly increased in all effector-expressed cell lines compared to a control cell line; these effector-expressed cell lines also showed significantly higher tolerance to permethrin. Inhibitor treatments on each effector-expressed cell line revealed that Bupivacaine HCl and H89 2HCl robustly inhibited cAMP production and PKA activity, respectively, resulting in decreased tolerance to permethrin in all cell lines. The synergistic functions of Bupivacaine HCl and H89 2HCl with permethrin were further examined in Culex mosquito larvae, providing a valuable new information for mosquito control strategies.

KEYWORDS

G-protein coupled receptor regulation pathway, insecticide resistance, Sf9 cell

Title

Role of the G-Protein-Coupled Receptor Signaling Pathway in Insecticide Resistance

Author

Ting Li and Nannan Liu*

Publish date

2019 Sep

PMID

31364987

Abstract

The number of neurotransmitter-filled vesicles released into the synaptic cleft with each action potential dictates the reliability of synaptic transmission. Variability of this fundamental property provides diversity of synaptic function across brain regions, but the source of this variability is unclear. The prevailing view is that release of a single (univesicular release, UVR) or multiple vesicles (multivesicular release, MVR) reflects variability in vesicle release probability, a notion that is well-supported by the calcium-dependence of release mode. However, using mouse brain slices, we now demonstrate that the number of vesicles released is regulated by the size of the readily-releasable pool, upstream of vesicle release probability. Our results point to a model wherein protein kinase A and its vesicle-associated target, synapsin, dynamically control release site occupancy to dictate the number of vesicles released without altering release probability. Together these findings define molecular mechanisms that control MVR and functional diversity of synaptic signaling.

Research organism: Mouse

Title

The readily-releasable pool dynamically regulates multivesicular release

Author

Jada H Vaden,1 Gokulakrishna Banumurthy,1 Eugeny S Gusarevich,2† Linda Overstreet-Wadiche,1 and Jacques I Wadiche1

Publish date

2019