Furosemide

Catalogue Number

AV-B81206

Analysis Method

HPLC,NMR,MS

Specification

98%

Storage

2-8°C

Molecular Weight

330.74

Appearance

Botanical Source

Structure Type

Category

Standards;Natural Pytochemical;API

SMILES

C1=COC(=C1)CNC2=CC(=C(C=C2C(=O)O)S(=O)(=O)N)Cl

Synonyms

Mirfat/furesis/Odemase/Frumex/furosedon/Durafurid/Furosemide,5-(Aminosulfonyl)-4/chloro-2-([2/furanylmethyl]amino)benzoicacid/Frusemide/frusid/dryptal/Benzoic/acid,/5-(aminosulfonyl)-4/chloro-2-[(2/furanylmethyl)amino]-/Frusetic/Errolon/trofurit/Nicorol/Urex/macasirool/lasilix/Furosemid/Oedemex/Discoid/katlex/Impugan/profemin/desdemin/Furosemide/Fusid/4-Chloro-2-[(2-furylmethyl)amino]-5-sulfamoylbenzoic acid/Lasix/Eutensin/fulsix/rosemide/Fuluvamide/4-Chloro-N-Furfuryl-5-Sulfamoylanthranilic Acid

IUPAC Name

4-chloro-2-(furan-2-ylmethylamino)-5-sulfamoylbenzoic acid

Applications

ailure and edema.Target: NKCC Furosemide (INN/BAN) or frusemide is a loop diuretic used in the treatment of congestive heart failure and edema. It is most commonly marketed by Sanofi under the brand name Lasix, and also under the brand names Fusid and Frumex. It has also been used to prevent Thoroughbred and Standardbred race horses from bleeding through the nose during races.Along with some other diuretics, furosemide is also included on the World Anti-Doping Agency's banned drug list due to its alleged use as a masking agent for other drugs.Furosemide, like other loop diuretics, acts by inhibiting NKCC2, the luminal Na-K-2Cl symporter in the thick ascending limb of the loop of Henle. The action on the distal tubules is independent of any inhibitory effect on carbonic anhydrase or aldosterone; it also abolishes the corticomedullary osmotic gradient and blocks negative, as well as positive, free water clearance.Because of the large NaCl absorptive capacity of the loop of Henle, diuresis is not limited by development of acidosis, as it is with the carbonic anhydrase inhibitors. Additionally, furosemide is a noncompetitive subtype-specific blocker of GABA-A receptors. Furosemide has been reported to reversibly antagonize GABA-evoked currents of α6β2γ2 receptors at uM concentrations, but not α1β2γ2 receptors. During development, the α6β2γ2 receptor increases in expression in cerebellar granule neurons, corresponding to increased sensitivity to furosemide

Density

1.6±0.1 g/cm3

Solubility

Flash Point

305.9±32.9 °C

Boiling Point

582.1±60.0 °C at 760 mmHg

Melting Point

220 °C (dec.)(lit.)

InChl

InChl Key

WGK Germany

RID/ADR

HS Code Reference

2935900000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

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