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Gallic acid trimethyl ether

$42

  • Brand : BIOFRON

  • Catalogue Number : AV-H19021

  • Specification : 98%

  • CAS number : 118-41-2

  • Formula : C10H12O5

  • Molecular Weight : 212.2

  • PUBCHEM ID : 8357

  • Volume : 20mg

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Catalogue Number

AV-H19021

Analysis Method

HPLC,NMR,MS

Specification

98%

Storage

2-8°C

Molecular Weight

212.2

Appearance

White crystalline powder

Botanical Source

Structure Type

Phenols

Category

Standards;Natural Pytochemical;API

SMILES

COC1=CC(=CC(=C1OC)OC)C(=O)O

Synonyms

3,4,5-Trimethoxybenzoic acid/3,4,5-Trimethoxy-benzoic acid/Eudesmic acid/Gallic acid trimethyl ether/Benzoic acid, 3,4,5-trimethoxy-/Tri-O-methylgallic acid

IUPAC Name

3,4,5-trimethoxybenzoic acid

Density

1.2±0.1 g/cm3

Solubility

Flash Point

128.8±20.0 °C

Boiling Point

376.3±0.0 °C at 760 mmHg

Melting Point

168-171 °C(lit.)

InChl

InChl Key

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:118-41-2) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

24374339

Abstract
The phosphatase enzyme calcineurin controls gene expression in a variety of biological contexts however few potent inhibitors are currently available. A screen of 360 plant extracts for inhibition of calcineurin-dependent gene expression in the model organism Saccharomyces cerevisiae identified the compound 3,4,5-trimethoxybenzyl isothiocyanate as an inhibitor. The compound was subsequently shown to inhibit human calcineurin via a mixed inhibition mechanism. To gain further mechanistic insight a yeast haploinsufficiency screen of 1152 deletion strains was carried out using a novel liquid medium screening method. The resulting haploinsufficiency profile is similar to that reported for the known calcineurin inhibitor FK506. Copyright ? 2013 Federation of European Biochemical Societies. All rights reserved.
KEYWORDS

3,4,5-Trimethoxybenzyl isothiocyanate; Calcineurin; Haploinsufficiency screen; Iberis saxatilis; Yeast

Title

A yeast chemical genetics approach identifies the compound 3,4,5-trimethoxybenzyl isothiocyanate as a calcineurin inhibitor.

Author

Prescott TA1, Panaretou B2, Veitch NC3, Simmonds MS3.

Publish date

2014 Jan 31

PMID

24354193

Abstract
Two new compounds, (+)-rumphiin (3) and polyalthurea (7), together with seven known ones, 3,4,5-trimethoxy benzoic acid (1), (-)-seselinone (2), cannabisin D (4), allantoin (5), oxostephanine (6) and a mixture of beta-sitosterol (8) and stigmasterol (9) were isolated from the stems of Polyalthia rumphii. The chemical structures of 3 and 7 were elucidated by the combination of spectroscopic data, and the absolute configuration of 3 at C-2 was determined by the matrix method to be R. All compounds were evaluated for their cytotoxicity on four human cancer cell lines, which demonstrated that 3 was a moderate bioactive lignan, and 6 showed significant anticancer activity against SPC-A-1 and BEL-7402 cell lines with IC50 values of 1.47 and 1.73 microg/mL, respectively.
Title

(+)-rumphiin and polyalthurea, new compounds from the stems of Polyalthia rumphii.

Author

Wang TS1, Luo YP, Wang J, He MX, Zhong MG, Li Y, Song XP.

Publish date

2013 Oct

PMID

22246731

Abstract
The biotransformation potential of a selected Atropa belladonna hairy root clone (AB-09) had been evaluated with regard to three different aromatic carbonyl compounds, i.e., 3,4,5-trimethoxybenzaldehyde (1), 3,4,5-trimethoxyacetophenone (2), and 3,4,5-trimethoxy benzoic acid (3). The results demonstrated for the first time the untapped potentials of the selected hairy root clone to perform simultaneous oxidation (34.49%) and reduction (32.68%) of 3,4,5-trimethoxy benzaldehyde (1) into 3,4,5-trimethoxy benzoic acid (3), and 3,4,5-trimethoxy benzyl alcohol (4), respectively, without any intermediate separation or addition of reagents. The same hairy root clone also demonstrated reduction (<5%) of a 3,4,5-trimethoxyacetophenone (2) into a secondary alcohol, i.e., 1-(3,4,5-trimethoxyphenyl) ethanol (5), while in the case of aromatic carboxylic acid substrate (3), no biotransformation could be obtained under the similar conditions. The current observations revealed oxidation and reduction of the formyl group of the aromatic ring, and only reduction of the carbonyl group of acetophenone through the specific hairy root clone. The concurrent oxidation and reduction reactions by the selected hairy root clone highlight the importance of this study, which, as per our observations, is the first of its kind relating the hairy root culture of A. belladonna.
Title

Atropa belladonna hairy roots: orchestration of concurrent oxidation and reduction reactions for biotransformation of carbonyl compounds.

Author

Srivastava V1, Negi AS, Ajayakumar PV, Khan SA, Banerjee S.

Publish date

2012 Mar


Description :

3,4,5-Trimethoxybenzoic acid (Eudesmic acid;Trimethylgallic Acid) is a benzoic acid derivative. A building block in medicine and organic synthesis.