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Ganhuangenin

$1,274

  • Brand : BIOFRON

  • Catalogue Number : BN-O1315

  • Specification : 98%(HPLC)

  • CAS number : 92519-91-0

  • Formula : C17H14O8

  • Molecular Weight : 346.2896

  • PUBCHEM ID : 5271991

  • Volume : 5mg

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Catalogue Number

BN-O1315

Analysis Method

HPLC,NMR,MS

Specification

98%(HPLC)

Storage

-20℃

Molecular Weight

346.2896

Appearance

Yellow powder

Botanical Source

This product is isolated and purified from the roots of Scutellaria viscidula Bge.

Structure Type

Flavonoids

Category

Standards;Natural Pytochemical;API

SMILES

COC1=C(C=CC(=C1C2=CC(=O)C3=C(O2)C(=C(C=C3O)O)OC)O)O

Synonyms

2',5,5',7-Tetrahydroxy-6',8-dimethoxyflavone/5,7,2',5'-tetrahydroxy-8,6'-dimethoxyflavone/viscidulin III/Sb 1/2-(3,6-Dihydroxy-2-methoxyphenyl)-5,7-dihydroxy-8-methoxy-4H-chromen-4-one/5,7,3',6'-Tetrahydroxy-8,2'-dimethoxyflavone/Ganhuangenin/4H-1-Benzopyran-4-one, 2-(3,6-dihydroxy-2-methoxyphenyl)-5,7-dihydroxy-8-methoxy-/1',2',5,7-tetrahydroxy-2',8-dimethoxy-flavone

IUPAC Name

2-(3,6-dihydroxy-2-methoxyphenyl)-5,7-dihydroxy-8-methoxychromen-4-one

Density

1.6±0.1 g/cm3

Solubility

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

Flash Point

251.5±25.0 °C

Boiling Point

673.7±55.0 °C at 760 mmHg

Melting Point

InChl

InChI=1S/C17H14O8/c1-23-15-8(19)4-3-7(18)14(15)12-6-10(21)13-9(20)5-11(22)16(24-2)17(13)25-12/h3-6,18-20,22H,1-2H3

InChl Key

CPFJPTACQDZPLS-UHFFFAOYSA-N

WGK Germany

RID/ADR

HS Code Reference

2914500000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:92519-91-0) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

11933121

Abstract

We previously showed that ganhuangenin (GHG) has beneficial antioxidative properties against lipid peroxidation in tissues of Sprague-Dawley (SD) rats. In this study, the effect of GHG on immunoglobulin E (IgE), histamine and leukotriene B(4) (LTB(4)) levels of cells isolated from SD rats was examined with regard to the manifestation of the type I allergic reaction. We showed that GHG inhibited the IgE production of mesenteric lymph node (MLN) lymphocytes. In the presence or absence of concanavalin A (ConA), the concentration used did not exert a toxic effect against MLN lymphocytes. Interestingly, the increase in the IgE content and lipid peroxidation induced by ConA was alleviated in the presence of GHG. Moreover, GHG also inhibited histamine release from the peritoneal exudate cells stimulated with a calcium ionophore, A23187, or with the histamine releaser, compound 48/80. In the case of LTB(4), GHG markedly inhibited its release at a concentration of 100 microM. Thus, it is concluded that GHG may block the common pathway for the release of histamine and LTB(4), and that the IgE level is responsible for the lipid peroxidation induced by ConA.

Copyright 2002 John Wiley & Sons, Ltd.

Title

Effect of ganhuangenin obtained from Scutellaria radix on the chemical mediator production of peritoneal exudate cells and immunoglobulin E level of mesenteric lymph node lymphocytes in Sprague-Dawley rats.

Author

Lim BO1.

Publish date

2002 Mar

PMID

10479757

Abstract

The antioxidative effect of ganhuangenin (GHG), isolated from Scutellaria baicalensis Georgi, was examined by measuring its ability to suppress the formation of phospatidylcholine hydroperoxide (PCOOH). The results show that a pretreatment with GHG effectively suppressed PCOOH formation, which was initiated by the peroxyl-generating oxidant, AAPH (2,2′-azobis-2-aminopropane hydrochloride). The protective action of GHG against the formation of the PCOOH was observed in liver, lung, and kidney. When compared with other known antioxidants, we found the antioxidative potency of GHG to be greater than that of alpha-tocopherol. Our data strongly indicate that GHG is a powerful antioxidant against lipid peroxidation and is, therefore, responsible for this prophylactic effect.

Title

The antioxidative effect of ganhuangenin against lipid peroxidation.

Author

Lim BO1, Yu BP, Kim SC, Park DK.

Publish date

1999 Sep

PMID

6544550

Title

[The structure of ganhuangenin, a new flavonoid from the root of gansuhuangqin (Scutellaria rehderiana)].

Author

Liu YL, Song WZ, Ji QY, Bai YL.

Publish date

1984 Nov


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