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Ganoderic acid B

$524

  • Brand : BIOFRON

  • Catalogue Number : BD-P0608

  • Specification : 98.0%(HPLC)

  • CAS number : 81907-61-1

  • PUBCHEM ID : 471003

  • Volume : 25mg

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Catalogue Number

BD-P0608

Analysis Method

HPLC,NMR,MS

Specification

98.0%(HPLC)

Storage

2-8°C

Molecular Weight

Appearance

Powder

Botanical Source

Ganodermalucidum(Leyss.exFr.)Karst.

Structure Type

Triterpenoids

Category

Standards;Natural Pytochemical;API

SMILES

CC(CC(=O)CC(C)C(=O)O)C1CC(=O)C2(C1(CC(=O)C3=C2C(CC4C3(CCC(C4(C)C)O)C)O)C)C

Synonyms

Ganoderic acid β/Ganoderic acid A/(7|A,15|A,25r)-7,15-dihydroxy-3,11,23-trioxolanost-8-en-26-oic acid/(3β,7β,25R)-3,7-Dihydroxy-11,15,23-trioxolanost-8-en-26-oic acid/ganoderic acid B/Lanost-8-en-26-oic acid, 3,7-dihydroxy-11,15,23-trioxo-, (3β,7β)-/Ganoderic acid/Lanost-8-en-26-oic acid, 3,7-dihydroxy-11,15,23-trioxo-, (3β,7β,25R)-/(3β,7β)-3,7-Dihydroxy-11,15,23-trioxolanost-8-en-26-oic acid/24,25-Dihydrolanosterol

IUPAC Name

(2R,6R)-6-[(3S,5R,7S,10S,13R,14R,17R)-3,7-dihydroxy-4,4,10,13,14-pentamethyl-11,15-dioxo-2,3,5,6,7,12,16,17-octahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-methyl-4-oxoheptanoic acid

Applications

Ganoderic acid B is a triterpene isolated from a mushroom Ganoderma lucidum. Ganoderic acid B inhibits the activation of Epstein-Barr virus (EBV) antigens as telomerase inhibitor. Ganoderic acid B is a moderately active inhibitor against HIV-1 protease[1][2][3]

Density

1.2±0.1 g/cm3

Solubility

Methanol

Flash Point

384.4±28.0 °C

Boiling Point

689.0±55.0 °C at 760 mmHg

Melting Point

InChl

InChI=1S/C30H44O7/c1-15(10-17(31)11-16(2)26(36)37)18-12-23(35)30(7)25-19(32)13-21-27(3,4)22(34)8-9-28(21,5)24(25)20(33)14-29(18,30)6/h15-16,18-19,21-22,32,34H,8-14H2,1-7H3,(H,36,37)/t15-,16-,18-,19+,21+,22+,28+,29-,30+/m1/s1

InChl Key

LWPLEHFGBRFRKI-NBCWKOIPSA-N

WGK Germany

RID/ADR

HS Code Reference

2918290000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:81907-61-1) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

25834543

Abstract

BACKGROUND:
Ganoderic acid B is an important bioactive ingredient isolated from Ganoderma lucidum, and exhibits various pharmacological activities.

AIMS:
To investigate the influence of Ganoderic acid B towards the therapeutic window of trifluoperazine (TFP).

METHODS:
In vitro human liver microsomes (HLMs) incubation system was used to determine the inhibition of Ganoderic acid B towards the glucuronidation of trifluoperazine (TFP).

RESULTS:
Ganoderic acid B exerted concentration-dependent inhibition towards the glucuronidation of TFP. Furthermore, Dixon plot was used to determine the inhibition type. The intersection point was located in the second quadrant in Dixon plot, indicating the competitive inhibition of Ganoderic acid B towards TFP glucuronidation. Through fitting the data using competitive nonlinear fitting equation, the inhibition kinetic parameter was calculated to be 56.7 uM.

CONCLUSION:
All this data indicated the potential influence of Ganoderic acid B-containing herbs towards therapeutic window of TFP. Given that the glucuronidation reaction of TFP is the probe reaction of UGT1A4, the data obtained from the present study also indicated the potential influence of Ganoderic acid-containing herbs towards the therapeutic window of drugs mainly undergoing UGT1A4-mediated metabolism.

KEYWORDS

Ganoderic acid B; UDP-glucuronosyltransferase (UGT) 1A4; trifluoperazine (TFP)

Title

Ganoderic acid B's influence towards the therapeutic window of trifluoperazine (TFP).

Author

Guo J1, Ni C2, Liu X3, Liu T4.

Publish date

2015 Mar

PMID

12575063

Abstract

The paper reports the assay of ganoderic acid B from Ganoderma lucidum in different places and stages by means of HPLC. The results show that contents of ganoderic acid B from different cultured places have differnces, different stages have effect on the amount too.

Title

[Effects of places and stages on the contents of ganoderic acid B from Ganoderma lucidum].

Author

Ding P1, Zhen Y, Lai X, Xu H.

Publish date

1999 Jun