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Gardneramine

$1,280

  • Brand : BIOFRON

  • Catalogue Number : BN-O0632

  • Specification : 95%(HPLC)

  • CAS number : 34274-91-4

  • Formula : C23H28N2O5

  • Molecular Weight : 412.48

  • PUBCHEM ID : 6441560

  • Volume : 5mg

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Catalogue Number

BN-O0632

Analysis Method

Specification

95%(HPLC)

Storage

-20℃

Molecular Weight

412.48

Appearance

Powder

Botanical Source

This product is isolated and purified from the roots of Gardneria multiflora Makino

Structure Type

Category

SMILES

COCC=C1CN2C3CC1C4C2CC35C6=C(C(=CC(=C6OC)OC)OC)N=C5OC4

Synonyms

(12S,13S,16Z,17S)-3,4,6-Trimethoxy-16-(2-methoxyethylidene)-10-oxa-8,14-diazahexacyclo[11.6.1.0.0.0.0]icosa-2,4,6,8-tetraene/8,11,12a-Ethanylylidene-7H-pyrido[2',3':5,6]oxepino[2,3-b]indole, 7a,8,9,10,11a,12-hexahydro-1,2,4-trimethoxy-9-(2-methoxyethylidene)-, (7aS,8S,9Z,11aS)-/(5β,19E)-9,10,12,18-Tetramethoxy-1,2-didehydro-2,17-epoxy-5,16-cyclocorynox-19-en/8,11,12a-Ethanylylidene-7H-pyrido[2',3':5,6]oxepino[2,3-b]indole, 7a,8,9,10,11a,12-hexahydro-1,2,4-trimethoxy-9-(2-methoxyethylidene)-, (8S,9E,11aS,12aS,13S)-

IUPAC Name

Applications

Density

1.5±0.1 g/cm3

Solubility

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

Flash Point

298.7±32.9 °C

Boiling Point

570.3±60.0 °C at 760 mmHg

Melting Point

InChl

InChl Key

RIMDDIPKIZTBHU-KPDHXFAYSA-N

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:34274-91-4) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

31683708

Abstract

As a novel monoterpenoid indole alkaloid, gardneramine has been confirmed to possess excellent nervous depressive effects. However, there have been no reports about the measurement of gardneramine in vitro and in vivo. The motivation of this study was to establish and validate a specific, sensitive, and robust analytical method based on UHPLC-MS/MS for quantification of gardneramine in rat plasma and various tissues after intravenous administration. The analyte was extracted from plasma and tissue samples by protein precipitation with methanol using theophylline as an internal standard (I.S.). The analytes were separated on an Agilent ZORBAX Eclipse Plus C18 column using a gradient elution of acetonitrile and 0.1% formic acid in water at a flow rate of 0.3 mL/min. Gardneramine and I.S. were detected and quantified using positive electrospray ionization in multiple reaction monitoring (MRM) mode with transitions of m/z 413.1→217.9 for gardneramine and m/z 181.2→124.1 for I.S.. Perfect linearity range was 1-2000 ng/mL with a correlation coefficient (r2) of ≥0.990. The lower limit of quantification (LLOQ) of 1.0 ng/mL was adequate for application to different preclinical studies. The method was successfully applied for determination of gardneramine in bio-samples.

KEYWORDS

LC-MS/MS; gardneramine; monoterpenoid indole alkaloid; pharmacokinetics; tissue distribution.

Title

Development and Validation of a Sensitive UHPLC-MS/MS Method for the Measurement of Gardneramine in Rat Plasma and Tissues and its Application to Pharmacokinetics and Tissue Distribution Study.

Author

Zhao N1, Tan HR2, Chen QL3, Sun Q4, Wang L5, Song Y6, Olounfeh KM7, Meng FH8.

Publish date

2019 Oct 31;

PMID

6193306

Abstract

The ganglion blocking site of gardneramine (GA) and hirsutine (HS) was studied in the dog urinary bladder in an in situ preparation. GA and HS selectively inhibited the DMPP-induced contraction without having an antagonistic effect on the McN-A-343-induced and acetylcholine-induced contraction. In addition, since GA and HS showed a local anesthetic action weaker than that of procaine, the effect of procaine was studied on the same preparation. Procaine inhibited the McN-A-343-induced contraction, and it slightly inhibited the DMPP-induced and acetylcholine-induced contraction. From these findings, it is concluded that GA and HS inhibited the ganglionic transmission of the dog urinary bladder and that the blockade of the nicotinic receptor played a main role.

Title

Site of the ganglion blocking action of gardneramine and hirsutine in the dog urinary bladder in situ preparation.

Author

Ozaki Y, Harada M.

Publish date

1983 Apr;