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Gelsemiol

$1,152

  • Brand : BIOFRON

  • Catalogue Number : BN-O1493

  • Specification : 98%(HPLC)

  • CAS number : 110414-77-2

  • Formula : C10H16O4

  • Molecular Weight : 200.2

  • PUBCHEM ID : 10375526

  • Volume : 5mg

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Catalogue Number

BN-O1493

Analysis Method

HPLC,NMR,MS

Specification

98%(HPLC)

Storage

-20℃

Molecular Weight

200.2

Appearance

Powder

Botanical Source

This product is isolated and purified from the herbs of Verbena littoralis

Structure Type

Iridoids

Category

Standards;Natural Pytochemical;API

SMILES

CC1CC2C(C1CO)C(C(=O)O2)CO

Synonyms

2H-Cyclopenta[b]furan-2-one, hexahydro-3,4-bis(hydroxymethyl)-5-methyl-, (3R,3aS,4R,5S,6aS)-/(3R,3aS,4R,5S,6aS)-3,4-Bis(hydroxymethyl)-5-methylhexahydro-2H-cyclopenta[b]furan-2-one

IUPAC Name

(3R,3aS,4R,5S,6aS)-3,4-bis(hydroxymethyl)-5-methyl-3,3a,4,5,6,6a-hexahydrocyclopenta[b]furan-2-one

Density

1.2±0.1 g/cm3

Solubility

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

Flash Point

164.2±12.5 °C

Boiling Point

407.0±10.0 °C at 760 mmHg

Melting Point

InChl

InChI=1S/C10H16O4/c1-5-2-8-9(6(5)3-11)7(4-12)10(13)14-8/h5-9,11-12H,2-4H2,1H3/t5-,6+,7-,8-,9-/m0/s1

InChl Key

FNYPTQQTJGQJNF-BGKGJTHRSA-N

WGK Germany

RID/ADR

HS Code Reference

2933990000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:110414-77-2) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

Title

Abstracts from the 38th Annual Meeting of the Society of General Internal Medicine

Publish date

2015 Apr

PMID

28503393

Abstract

We present a procedure to perform and interpret pull-off force measurements during the jump-off-contact process between a liquid drop and rough surfaces using a conventional atomic force microscope. In this method, a micrometric liquid mercury drop is attached to an AFM tipless cantilever to measure the force required to pull this drop off a rough surface. We test the method with two surfaces: a square array of nanometer-sized peaks commonly used for the determination of AFM tip sharpness and a multi-scaled rough diamond surface containing sub-micrometer protrusions. Measurements are carried out in a nitrogen atmosphere to avoid water capillary interactions. We obtain information about the average force of adhesion between a single peak or protrusion and the liquid drop. This procedure could provide useful microscopic information to improve our understanding of wetting phenomena on rough surfaces.

KEYWORDS

atomic force microscopy, force of adhesion, functionalized-tip cantilevers, liquid probe

Title

Measuring adhesion on rough surfaces using atomic force microscopy with a liquid probe

Author

Juan V Escobar, Cristina Garza, Rolando Castillo

Publish date

2017;

PMID

25512507

Abstract

Long noncoding RNAs (lncRNAs) are transcripts longer than 200 nucleotides, located within the intergenic stretches or overlapping antisense transcripts of protein coding genes. LncRNAs are involved in numerous biological roles including imprinting, epigenetic regulation, apoptosis, and cell cycle. To determine whether lncRNAs are associated with clinical features and recurrent mutations in older patients (aged ≥60 y) with cytogenetically normal (CN) acute myeloid leukemia (AML), we evaluated lncRNA expression in 148 untreated older CN-AML cases using a custom microarray platform. An independent set of 71 untreated older patients with CN-AML was used to validate the outcome scores using RNA sequencing. Distinctive lncRNA profiles were found associated with selected mutations, such as internal tandem duplications in the FLT3 gene (FLT3-ITD) and mutations in the NPM1, CEBPA, IDH2, ASXL1, and RUNX1 genes. Using the lncRNAs most associated with event-free survival in a training cohort of 148 older patients with CN-AML, we derived a lncRNA score composed of 48 lncRNAs. Patients with an unfavorable compared with favorable lncRNA score had a lower complete response (CR) rate [P < 0.001, odds ratio = 0.14, 54% vs. 89%], shorter disease-free survival (DFS) [P < 0.001, hazard ratio (HR) = 2.88] and overall survival (OS) (P < 0.001, HR = 2.95). The validation set analyses confirmed these results (CR, P = 0.03; DFS, P = 0.009; OS, P = 0.009). Multivariable analyses for CR, DFS, and OS identified the lncRNA score as an independent marker for outcome. In conclusion, lncRNA expression in AML is closely associated with recurrent mutations. A small subset of lncRNAs is correlated strongly with treatment response and survival.

KEYWORDS

lncRNAs, acute myeloid leukemia, outcome

Title

Expression and prognostic impact of lncRNAs in acute myeloid leukemia

Author

Ramiro Garzon, Stefano Volinia, Dimitrios Papaioannou, Deedra Nicolet, Jessica Kohlschmidt, Pearlly S. Yan, Krzysztof Mrozek, Donna Bucci, Andrew J. Carroll, Maria R. Baer, Meir Wetzler, Thomas H. Carter, Bayard L. Powell, Jonathan E. Kolitz, Joseph O. Moore, Ann-Kathrin Eisfeld, James S. Blachly, William Blum, Michael A. Caligiuri, Richard M. Stone, Guido Marcucci, Carlo M. Croce, John C. Byrd, Clara D. Bloomfield

Publish date

2014 Dec 30;


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