We Offer Worldwide Shipping
Login Wishlist

Genipin

$43

  • Brand : BIOFRON

  • Catalogue Number : BF-G2003

  • Specification : 98%

  • CAS number : 6902-77-8

  • Formula : C11H14O5

  • Molecular Weight : 226.23

  • PUBCHEM ID : 442424

  • Volume : 20mg

In stock

Quantity
Checkout Bulk Order?

Catalogue Number

BF-G2003

Analysis Method

HPLC,NMR,MS

Specification

98%

Storage

2-8°C

Molecular Weight

226.23

Appearance

White crystalline powder

Botanical Source

Gardenia jasminoides

Structure Type

Terpenoids

Category

Standards;Natural Pytochemical;API

SMILES

COC(=O)C1=COC(C2C1CC=C2CO)O

Synonyms

Methyl (1R,4aS,7aS)-1-hydroxy-7-(hydroxymethyl)-1,4a,5,7a-tetrahydrocyclopenta[c]pyran-4-carboxylate/Cyclopenta[c]pyran-4-carboxylic acid, 1,4a,5,7a-tetrahydro-1-hydroxy-7-(hydroxymethyl)-, methyl ester, (1R,4aS,7aS)-

IUPAC Name

methyl (1R,4aS,7aS)-1-hydroxy-7-(hydroxymethyl)-1,4a,5,7a-tetrahydrocyclopenta[c]pyran-4-carboxylate

Density

1.4±0.1 g/cm3

Solubility

Flash Point

164.9±22.2 °C

Boiling Point

416.0±45.0 °C at 760 mmHg

Melting Point

106-108 °C(lit.)

InChl

InChl Key

WGK Germany

RID/ADR

HS Code Reference

2932990000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:6902-77-8) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

PMID

31955538

Abstract

OBJECTIVE:
To investigate the effects of bio-crosslinker genipin pretreatment on type Ⅰ collagen mineralization.

METHODS:
Type Ⅰ collagen gels were prepared and pretreated with 0.5wt%genipin (experimental group) and deionized water (control group) for 2 h, respectively. The pretreated products were subjected to Fourier transform infrared spectroscopy (FT-IR). Reconstituted collagen fibrils were pretreated with genipin or deionized water for 2 h and were mineralized for 4 h. The collagen density and mineralization degree were examined with transmission electron microscopy (TEM) and analyzed with ImageJ software. Then scanning electron microscopy (SEM) and TEM were used to observe the mineralization of cross-linked demineralized dentin collagen.

RESULTS:
FT-IR spectrum showed that the genipin was crosslinked with collagen. TEM observation and ImageJ results showed that after 4 h mineralization, the mineralization effect of 0.5wt% genipin group was significantly better than that of the control group[(73.3±5.3)%vs.(7.4±3.5)%,P<0.01]. TEM and SEM observation showed that the mineralization rate of type Ⅰ collagen and demineralized dentin pretreated with genipin were significantly faster than that of the control group.

CONCLUSIONS:
The study demonstrates that 0.5 wt% concentration of genipin can significantly promote the mineralization of type Ⅰ collagen.

Title

[Effect of genipin pretreatment on type Ⅰ collagen mineralization].

Author

Gu T1, Shuai J1, Chen C2, Feng J1.

Publish date

2019 Dec 25

PMID

31682429

Abstract

Genipin, a natural electrophilic cross-linker, was applied (5, 10, 20, and 30 mM) to modify hempseed protein isolate (HPI). Genipin treatments resulted in general losses of total sulfhydryls (up to 2.9 nmol/mg) and free amines (up to 77.3 nmol/mg). Surface hydrophobicity decreased by nearly 90% with 30 mM genipin, corresponding to similar tryptophan fluorescence quenching. The genipin treatment converted HPI into highly cross-linked polymers. Hydrogels formed with such polymers when also incorporated with hemp oil emulsions exhibited substantially enhanced gelling ability: up to 3.3- and 2.6-fold increases, respectively, in gel strength and gel elasticity over genipin-untreated protein. The genipin-modified composite gels also exhibited superior water-holding capacity. Microstructural analysis revealed a compact gel network filled with protein-coated oil globules that interacted intimately with the protein matrix when treated with genipin. Such gels remained readily digestible. Hence, genipin-treated hemp protein hydrogels show promise as functional food components.

KEYWORDS

composite gel; cross-linking; genipin; hemp protein

Title

Genipin-Aided Protein Cross-linking to Modify Structural and Rheological Properties of Emulsion-Filled Hempseed Protein Hydrogels.

Author

Wang Q1, Jiang J1, Xiong YL1,2.

Publish date

2019 Nov 20

PMID

31571857

Abstract

BACKGROUND:
Therapeutic proteins have been widely used in the treatment of various diseases, and effective carriers are highly required for achieving protein delivery to obtain favorable treatment potency.

MATERIALS AND METHODS:
A protein-polymer hybrid system was constructed through the genipin-mediated crosslinking of polyethyleneimine with a weight-average molecular weight of 25,000 g/mol (PEI25K) and ribonuclease A (RNase A), namely RGP.

RESULTS:
The RGP nanoparticles were observed to be easily internationalized in HeLa cells owing to the introduction of positively charged PEI25K, thereby triggering the antiproliferative effects by cleaving RNA molecules in the tumor cells. Moreover, red fluorescence could be obviously visualized in the tumor cells after RGP delivery, which was attributed to the intrinsic characteristics of genipin.

CONCLUSION:
The protein-polymer hybrid system prepared via the genipin-mediated crosslinking has exhibited potential to be used as a theranostic platform for both in vivo imaging and delivering diverse therapeutic proteins.

© 2019 Liang et al.

KEYWORDS

antitumor efficacy; genipin; polyethyleneimine; protein delivery; ribonuclease A

Title

A genipin-crosslinked protein-polymer hybrid system for the intracellular delivery of ribonuclease A.

Author

Liang X1, Tang X1, Yang J1, Zhang J1, Han H1, Li Q1.

Publish date

2019 Sep 10


Description :

Genipin is a natural water soluble crosslinking reagent.