This product is isolated and purified from the roots of Panax ginseng C. A. Mey.
(3β,6α,12β)-3,6,12-Trihydroxydammar-24-en-20-yl 6-O-α-L-arabinopyranosyl-β-D-glucopyranoside/Ginsenoside F3/β-D-Glucopyranoside, (3β,6α,12β)-3,6,12-trihydroxydammar-24-en-20-yl 6-O-α-L-arabinopyranosyl-
Chem Pharm Bull (Tokyo). 2013;61(3):273-8. Four new triterpenoid saponins from the leaves of Panax japonicus grown in southern Miyazaki Prefecture (4).[Pubmed: 23238233]METHODS AND RESULTS:Four new dammarane-type triterpenoid saponins such as chikusetsusaponin LM3 (1), chikusetsusaponin LM4 (2), chikusetsusaponin LM5 (3), chikusetsusaponin LM6 (4), and twenty known triterpenoid saponins such as ginsenoside Rb3 (5), ginsenoside Rc (6), ginsenoside Rd (7), ginsenoside Re (8), ginsenoside Rg1 (9), Ginsenoside F3 (10), ginsenoside F5 (11), ginsenoside F6 (12), chikusetsusaponin IVa (13), chikusetsusaponin V (14), chikusetsusaponin L5 (15), chikusetsusaponin L9a (16), chikusetsusaponin L9bc (17), chikusetsusaponin L10 (18), chikusetsusaponin FK2 (19), chikusetsusaponin FK6 (20), chikusetsusaponin FK7 (21), chikusetsusaponin FT1 (22), chikusetsusaponin LM1 (23), and chikusetsusaponin LM2 (24), were isolated from the leaves of Panax japonicus C. A. MEYER collected in Miyazaki prefecture, Japan. CONCLUSIONS:The structures of new chikusetsusaponins were elucidated on the basis of spectral and physicochemical evidences.Nat Prod Commun. 2012 Apr;7(4):491-3. New triterpenoid saponins from leaves of Panax japonicus (3). Saponins of the specimens collected in Miyazaki prefecture.[Pubmed: 22574450]Two new dammarane-type triterpenoid saponins, chikusetsusaponin LM1 (1), chikusetsusaponin LM2 (2), and three known triterpenoid saponins, ginsenoside Re (3), ginsenoside Rg1 (4), Ginsenoside F3 (5), were isolated from the leaves of P. japonicus C. A. Meyer collected in Miyazaki prefecture, Japan. The structures of new chikusetsusaponins were elucidated on the basis of spectroscopic and physicochemical evidences.
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
873.3±65.0 °C at 760 mmHg
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provides coniferyl ferulate(CAS#:62025-50-7) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate
Assassin flies (Diptera: Asilidae) inject paralysing venom into insect prey during hunting, but their venoms are poorly characterised in comparison to those produced by spiders, scorpions, or hymenopteran insects. Here we investigated the composition of the venom of the giant Australian assassin fly Dolopus genitalis using a combination of insect microinjection assays, calcium imaging assays of mammalian sensory neurons, proteomics and transcriptomics. Injection of venom into blowflies (Lucilia cuprina) produced rapid contractile paralysis (PD50 at 1 min = 3.1 μg per fly) followed by death, and also caused immediate activation of mouse dorsal root ganglion neurons (at 50 ng/μL). These results are consistent with venom use for both prey capture and predator deterrence. Paragon searches of tandem mass spectra of venom against a translated thoracic gland RNA-Seq database identified 122 polypeptides present in the venom, including six linear and 21 disulfide-rich peptides. Some of these disulfide-rich peptides display sequence homology to peptide families independently recruited into other animal venoms, including inhibitor cystine knots, cystine-stabilised α/β defensins, Kazal peptides, and von Willebrand factors. Numerous enzymes are present in the venom, including 35 proteases of the S1 family, proteases of the S10, C1A, M12A, M14, and M17 families, and phosphatase, amylase, hydrolase, nuclease, and dehydrogenase-like proteins. These results highlight convergent molecular evolution between the assassin flies and other venomous animals, as well as the unique and rich molecular composition of assassin fly venom.
venom, peptide, defensin, Asilidae, Diptera, insect venom, Asilidin, inhibitor cystine knot, extra-oral digestion
Buzz Kill: Function and Proteomic Composition of Venom from the Giant Assassin Fly Dolopus genitalis (Diptera: Asilidae)
Andrew A. Walker,1,*† James Dobson,2,† Jiayi Jin,1,† Samuel D. Robinson,1,3 Volker Herzig,1 Irina Vetter,1,4 Glenn F. King,1,* and Bryan G. Fry2,*
2018 Nov 5.
Infertility in men and women is a complex genetic trait with shared biological bases between the sexes. Here, we perform a series of rare variant analyses across 73,185 women and men to identify genes that contribute to primary gonadal dysfunction. We report CSMD1, a complement regulatory protein on chromosome 8p23, as a strong candidate locus in both sexes. We show that CSMD1 is enriched at the germ-cell/somatic-cell interface in both male and female gonads. Csmd1-knockout males show increased rates of infertility with significantly increased complement C3 protein deposition in the testes, accompanied by severe histological degeneration. Knockout females show significant reduction in ovarian quality and breeding success, as well as mammary branching impairment. Double knockout of Csmd1 and C3 causes non-additive reduction in breeding success, suggesting that CSMD1 and the complement pathway play an important role in the normal postnatal development of the gonads in both sexes.
Subject terms: Genetic association study, Structural variation, Menopause, Infertility
Rare mutations in the complement regulatory gene CSMD1 are associated with male and female infertility
Arthur S. Lee,1 Jannette Rusch,1 Ana C. Lima,1 Abul Usmani,1 Ni Huang,1 Maarja Lepamets,2 Katinka A. Vigh-Conrad,3 Ronald E. Worthington,4 Reedik Magi,2 Xiaobo Wu,5 Kenneth I. Aston,6 John P. Atkinson,5 Douglas T. Carrell,6 Rex A. Hess,7 Moira K. O’Bryan,8 and Donald F. Conradcorresponding author1,3,9
2019 Oct 11.
Image-guided surgery can enhance cancer treatment by decreasing, and ideally eliminating, positive tumor margins and iatrogenic damage to healthy tissue. Current state-of-the-art near-infrared fluorescence imaging systems are bulky and costly, lack sensitivity under surgical illumination, and lack co-registration accuracy between multimodal images. As a result, an overwhelming majority of physicians still rely on their unaided eyes and palpation as the primary sensing modalities for distinguishing cancerous from healthy tissue. Here we introduce an innovative design, comprising an artificial multispectral sensor inspired by the Morpho butterfly’s compound eye, which can significantly improve image-guided surgery. By monolithically integrating spectral tapetal filters with photodetectors, we have realized a single-chip multispectral imager with 1000 × higher sensitivity and 7 × better spatial co-registration accuracy compared to clinical imaging systems in current use. Preclinical and clinical data demonstrate that this technology seamlessly integrates into the surgical workflow while providing surgeons with real-time information on the location of cancerous tissue and sentinel lymph nodes. Due to its low manufacturing cost, our bio-inspired sensor will provide resource-limited hospitals with much-needed technology to enable more accurate value-based health care.
Bio-inspired imager improves sensitivity in near-infrared fluorescence image-guided surgery
Missael Garcia,1,13 Christopher Edmiston,1 Timothy York,2 Radoslav Marinov,1,3 Suman Mondal,4,5 Nan Zhu,6 Gail P. Sudlow,4 Walter J. Akers,4 Julie Margenthaler,7 Samuel Achilefu,4,5,10 Rongguang Liang,6 Mohamed A. Zayed,8,9 Marta Y. Pepino,11 and Viktor Gruev12,13,*
2018 Nov 19.