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Glomeratose A

$390

  • Brand : BIOFRON

  • Catalogue Number : AV-H17103

  • Specification : 98%

  • CAS number : 202471-84-9

  • Formula : C24H34O15

  • Molecular Weight : 562.52

  • PUBCHEM ID : 73157754

  • Volume : 20mg

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Catalogue Number

AV-H17103

Analysis Method

HPLC,NMR,MS

Specification

98%

Storage

-20℃

Molecular Weight

562.52

Appearance

White crystalline powder

Botanical Source

Polygala tenuifolia/Polygala senega and Polygala tenuifolia

Structure Type

Phenylpropanoids

Category

Standards;Natural Pytochemical;API

SMILES

COC1=CC(=CC(=C1OC)OC)C=CC(=O)OC2C(C(OC2(CO)OC3C(C(C(C(O3)CO)O)O)O)CO)O

Synonyms

3-O-[(2E)-3-(3,4,5-Trimethoxyphenyl)-2-propenoyl]-β-D-fructofuranosyl α-D-glucopyranoside/α-D-Glucopyranoside, 3-O-[(2E)-1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propen-1-yl]-β-D-fructofuranosyl

IUPAC Name

[4-hydroxy-2,5-bis(hydroxymethyl)-2-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxolan-3-yl] 3-(3,4,5-trimethoxyphenyl)prop-2-enoate

Applications

Density

1.5±0.1 g/cm3

Solubility

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

Flash Point

274.9±27.8 °C

Boiling Point

826.5±65.0 °C at 760 mmHg

Melting Point

InChl

InChI=1S/C24H34O15/c1-33-12-6-11(7-13(34-2)21(12)35-3)4-5-16(28)37-22-18(30)15(9-26)38-24(22,10-27)39-23-20(32)19(31)17(29)14(8-25)36-23/h4-7,14-15,17-20,22-23,25-27,29-32H,8-10H2,1-3H3/b5-4+/t14-,15-,17-,18-,19+,20-,22+,23-,24-/m1/s1

InChl Key

PQHNJDATPYXLIX-YRUWNDPZSA-N

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:202471-84-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

29261155

Abstract
The quality control of Polygala tenuifolia Wild. is a major challenge in its clinical application. In this paper, a new strategy for the quality evaluation of P. tenuifolia extracts was verified through reverse-phase ultra-performance liquid chromatography (UPLC). The quantitative analysis of multi-components by a single marker (QAMS) was conducted with 3,6'-disinapoyl sucrose as an internal reference substance. Eight components (i.e., sibiricose A5, sibiricose A6, glomeratose A, tenuifoliside A, tenuifoliside B, tenuifoliside C, sibiricaxanthone B, and polygalaxanthone III) were determined based on the relative correction factors. The concentrations of these components were also determined by applying a conventional external standard method. The cosine value confirmed the consistency of the two methods (cosine ratio value >0.999920). Hierarchical cluster analysis, radar plots, and discriminant analysis were performed to classify 23 batches of P. tenuifolia extracts from Shanxi, Hebei, and Shaanxi in China. Results revealed that QAMS combined with radar plots and multivariate data analysis could accurately measure and clearly distinguish the different quality samples of P. tenuifolia. Hence, QAMS is a feasible and promising method for the quality control of P. tenuifolia.
KEYWORDS

Polygala tenuifolia Wild.; multi-components by single marker; quality evaluation; ultra-performance liquid chromatography

Title

UPLC Quantitative Analysis of Multi-Components by Single Marker and Quality Evaluation of Polygala tenuifolia Wild. Extracts.

Author

Xu R1, Mao F2,3, Zhao Y4,5,6, Wang W7,8, Fan L9, Gao X10,11, Zhao J12,13, Tian H14.

Publish date

2017 Dec 20

PMID

30520580

Abstract
A new ajmaline-type alkaloid, 21-Ο-methylisoajmaline (1), together with twenty-one known compounds, a mixture of β-sitosterol (2) and stigmasterol (3), reserpinine (4); tetrahydroalstonine (5), reserpine (6), venoterpine (7), yohimbine (8), 6'-O-(3,4,5-trimethoxybenzoyl)glomeratose A (9), isoajmaline (10), 3-epi-α-yohimbine (11), methyl 3,4,5-trimethoxy-trans-cinnamate (12), a mixture of β-sitosterol 3-Ο-β-D-glucopyranoside (13) and stigmasterol 3-Ο-β-D- glucopyranoside (14), rescidine (15), 7-deoxyloganic acid (16), ajmaline (17), suaveoline (18), (+)-tetraphyllicine (19), loganic acid (20), 3-hydroxysarpagine (21), and sarpagine (22), were isolated from the roots of Rauvolla serpentina. Their structures were elucidated by spectroscopic data analysis and comparison with literature data. Compounds 11, 12 and 15 were for the first time identified from the genus Rauvolfla and 5, 7, 11, 12, 15, 18 and 22 were found from R. sepentina for the first time. Compound 11 showed moderate anticholinesterase activity with IC?? value of 15.58 μM, whereas 6 exhibited strong vasorelaxant activity with the EC?? value of 0.05 μM.
Title

A New Ajmaline-type Alkaloid from the Roots of Rauvolfia serpentina.

Author

Rukachaisirikul T, Chokchaisiri S, Suebsakwong P, Suksamrarn A, Tocharus C.

Publish date

2017 Apr;

PMID

28134488

Abstract
Stroke is the second leading cause of death worldwide. Lactate dehydrogenase inhibitors are currently widely used in the treatment of ischemic stroke, and natural products are considered promising sources of lactate dehydrogenase inhibitors. In this study, ultrafiltration liquid chromatography coupled with mass spectrometry was used for the screening and identification of lactate dehydrogenase inhibitors from Polygala tenuifolia. Furthermore, five lactate dehydrogenase inhibitors, sibiricose A5, 3,6'-di-O-sinapoyl-sucrose, glomeratose A, tenuifoliside B, and tenuifoliside C, were selected as target lactate dehydrogenase inhibitors. In addition, the five target compounds with purities of 96.45, 97.65, 96.38, 94.34, and 93.29% were extracted and isolated using a new hyphenated strategy of microwave-assisted extraction coupled with countercurrent chromatography with a two-phase solvent system of n-hexane/n-butanol/ethanol/water (5.321:1.00:1.664:6.647). The bioactivities of the isolated compounds were analyzed using PC12 cells and the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. The results also demonstrated that microwave-assisted extraction coupled with countercurrent chromatography is an efficient method of isolating chemical constituents from medicinal herbs. Moreover, the research route consisting of activity screening, extraction, separation, and activity verification of the compounds has the advantages of being efficient, orientated, and objective. ? 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
KEYWORDS

countercurrent chromatography; lactate dehydrogenase inhibitors; microwave-assisted extraction; stroke; ultrafiltration

Title

Bioactivity screening, extraction, and separation of lactate dehydrogenase inhibitors from Polygala tenuifolia Willd. based on a hyphenated strategy.

Author

Li S1,2, Liu S1, Liu Z1, Liu C2, Song F1, Pi Z1.

Publish date

2017 Mar