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Glycozolinine

$1,184

  • Brand : BIOFRON

  • Catalogue Number : BN-O1532

  • Specification : 98%(HPLC)

  • CAS number : 5257-08-9

  • Formula : C13H11NO

  • Molecular Weight : 197.2

  • PUBCHEM ID : 11041703

  • Volume : 5mg

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Catalogue Number

BN-O1532

Analysis Method

Specification

98%(HPLC)

Storage

-20℃

Molecular Weight

197.2

Appearance

Powder

Botanical Source

This product is isolated and purified from the herbs of Micromelum sp.

Structure Type

Category

SMILES

CC1=CC2=C(C=C1)NC3=C2C=C(C=C3)O

Synonyms

6-Methyl-9H-carbazol-3-ol/9H-Carbazol-3-ol, 6-methyl-

IUPAC Name

Density

1.3±0.1 g/cm3

Solubility

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

Flash Point

219.3±23.2 °C

Boiling Point

439.0±25.0 °C at 760 mmHg

Melting Point

InChl

InChl Key

HGWWJXCROVKODY-UHFFFAOYSA-N

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:5257-08-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

30696034

Abstract

The objective of this study was to investigate the effects of different dietary energy levels on serum concentrations of growth hormone (GH) and insulin-like growth factor 1 (IGF-1), as well as gene expression of their associated binding proteins and receptors in yak. Fifteen adult male yaks with BW of 276.1 ± 3.5 kg were allotted in three dietary groups and were fed with low (LE), medium (ME), and high energy (HE) level diet having different NEg of 5.5 MJ/kg, 6.2 MJ/kg, 6.9 MJ/kg, respectively. The effects of these treatments on ADG, BW, ADFI, and feed conversion ratio were significant (p < 0.05) throughout the experimental period. Serum GH concentration decreased (p < 0.05) with an increase in dietary energy level on d 30 and d 60. While IGF-1 concentration was higher (p < 0.05) in ME group, as compared to LE and HE groups on d 60. The expression level of growth hormone receptor (GHR) was decreased (p < 0.001) and IGF-1 was increased with the increase in the dietary energy level. The relative expression of insulin-like growth factor binding protein 3 (IGFBP-3) was higher (p < 0.001) in ME and HE groups, except the LE group. In conclusion, our findings provide a first insight into the combined effect of GH and IGF-1 in controlling the metabolism and productivity of yak. It also showed that medium energy level diet contributed to promote growth performance of yak during the cold season.

KEYWORDS

Yak, dietary energy level, growth performance, growth hormone (GH), insulin-like growth factor 1 (IGF-1)

Title

Dietary Energy Levels Affect Growth Performance through Growth Hormone and Insulin-Like Growth Factor 1 in Yak (Bos grunniens)

Author

Chao Yang,1,2,† Jianbo Zhang,1,† Anum Ali Ahmad,3 Pengjia Bao,1 Xian Guo,1 Ruijun Long,3 Xuezhi Ding,1,* and Ping Yan1,*

Publish date

2019 Feb;

PMID

21175433

Abstract

The strong need for the development of alternative anti-HIV agents is primarily due to the emergence of strain-resistant viruses, the need for sustained adherence to complex treatment regimens and the toxicity of currently used antiviral drugs. This review analyzes proof of concept studies indicating that the immunomodulatory drug rapamycin (RAPA) possesses anti-HIV properties both in vitro and in vivo that qualifies it as a potential new anti-HIV drug. It represents a literature review of published studies that evaluated the in vitro and in vivo activity of RAPA in HIV. RAPA represses HIV-1 replication in vitro through different mechanisms including, but not limited, to down regulation of CCR5. In addition RAPA synergistically enhances the anti-HIV activity of entry inhibitors such as vicriviroc, aplaviroc and enfuvirtide in vitro. RAPA also inhibits HIV-1 infection in human peripheral blood leucocytes-SCID reconstituted mice. In addition, a prospective nonrandomized trial of HIV patient series receiving RAPA monotherapy after liver transplantation indicated significantly better control of HIV and hepatitis C virus (HCV) replication among patients taking RAPA monotherapy. Taken together, the evidence presented in this review suggests that RAPA may be a useful drug that should be evaluated for the prevention and treatment of HIV-1 infection.

KEYWORDS

CCR5, HIV, mTOR, rapamycin

Title

Potential use of rapamycin in HIV infection

Author

Marco Donia,1 James A McCubrey,2 Klaus Bendtzen,3 and Ferdinando Nicoletti1

Publish date

2010 Dec;

PMID

30304815

Abstract

Flavonoids are widely described plant secondary metabolites with high and diverse pro-health properties. In nature, they occur mostly in the form of glycosides. Our research showed that an excellent way to obtain the sugar derivatives of flavonoids is through biotransformations with the use of entomopathogenic filamentous fungi as biocatalysts. In the current paper, we described the biotransformations of five methoxylated flavonoid compounds (2′-methoxyflavanone, 3′-methoxyflavanone, 4′-methoxyflavanone, 6-methoxyflavanone, and 6-methoxyflavone) in cultures of Isaria fumosorosea KCH J2. As a result, we obtained twelve new flavonoid 4-O-methylglucopyranosides. The products were purified with methods that enabled the reduction of the consumption of organic solvents (preparative TLC and flash chromatography). The structures of the products were confirmed with spectroscopic methods (NMR: 1H, 13C, HSQC, HMBC, COSY). The compounds obtained by us expand the library of available flavonoid derivatives and can be used in biological research.

KEYWORDS

flavonoids, biotransformations, Isaria, fungi, flavonoid glycosides, 4-O-methylglucopyranoside, methoxyflavanone, methoxyflavone

Title

Glycosylation of Methoxylated Flavonoids in the Cultures of Isaria fumosorosea KCH J2

Author

Monika Dymarska,* Tomasz Janeczko, and Edyta Kostrzewa-Susłow

Publish date

2018 Oct;


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