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Glycyrrhizic acid

$58

  • Brand : BIOFRON

  • Catalogue Number : BD-D1332

  • Specification : 98%(HPLC)

  • CAS number : 1405-86-3

  • Formula : C42H62O16

  • Molecular Weight : 822.94

  • PUBCHEM ID : 14982

  • Volume : 20MG

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Catalogue Number

BD-D1332

Analysis Method

HPLC,NMR,MS

Specification

98%(HPLC)

Storage

2-8℃

Molecular Weight

822.94

Appearance

White crystal

Botanical Source

Glycyrrhiza uralensis Fisch./Glycyrrhiza glabra (liquorice), also from Polypodium vulgare, Pradosia and Periandra spp.

Structure Type

Triterpenoids

Category

Standards;Natural Pytochemical;API

SMILES

CC1(C2CCC3(C(C2(CCC1OC4C(C(C(C(O4)C(=O)O)O)O)OC5C(C(C(C(O5)C(=O)O)O)O)O)C)C(=O)C=C6C3(CCC7(C6CC(CC7)(C)C(=O)O)C)C)C)C

Synonyms

Glycyrrhizin/Olean-12-en-30-oic acid, 3-[(2-O-β-D-glucopyranuronosyl-α-D-glucopyranuronosyl)oxy]-11-oxo-, (3β)-/Potenlini/Glycyrrhizate/glycyron/DerMacrin/20b-Carboxy-11-oxo-30-norolean-12-en-3b-yl-2-O-b-D-glucopyranuronosyl-a-D-glucopyranosiduronic Acid/(3β)-30-Hydroxy-11,30-dioxoolean-12-en-3-yl 2-O-β-D-glucopyranuronosyl-α-D-glucopyranosiduronic acid/Glycyrrhizic acid/Glycyrrhizine/liquorice/(3b,20b)-20-Carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-b-D-Glucopyranuronosyl-a-D-glucopyranosiduronic Acid/30-Noroleanane, α-D-glucopyranosiduronic acid deriv/glycyrrhizinic acid/glycyrrhetinic acid glycoside/Glycyrrhitin/Glycyrrhizi

IUPAC Name

(2S,3S,4S,5R,6R)-6-[(2S,3R,4S,5S,6S)-2-[[(3S,4aR,6aR,6bS,8aS,11S,12aR,14aR,14bS)-11-carboxy-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-2,3,4a,5,6,7,8,9,10,12,12a,14a-dodecahydro-1H-picen-3-yl]oxy]-6-carboxy-4,5-dihydroxyoxan-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid

Applications

Glycyrrhizic acid is a triterpenoid saponinl, acting as a direct HMGB1 antagonist, with anti-tumor, anti-diabetic activities.

Density

1.4±0.1 g/cm3

Solubility

Methanol; DMSO

Flash Point

288.1±27.8 °C

Boiling Point

971.4±65.0 °C at 760 mmHg

Melting Point

220ºC decomposes

InChl

InChl Key

WGK Germany

RID/ADR

HS Code Reference

2938900000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:1405-86-3) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

28886526

Abstract

Drug delivery systems have become an integral part of anticancer drugs today. Design of novel drug carriers may lead to significant enhancement in antineoplastic therapy. Glycyrrhizic acid (GL), which is the most important active ingredient extracted from the licorice root shows great potential as a carrier material in this field. Recent studies have indicated that the combination of GL and first-line drugs had better therapeutic effects on cancers. GL showed a series of anti-cancer-related pharmacological activities, such as broad-spectrum anti-cancer ability, resistance to the tissue toxicity caused by chemotherapy and radiation, drug absorption enhancing effects and anti-multidrug resistance (MDR) mechanisms, as a carrier material in drug delivery systems. This review introduced the current research progress on pharmacological mechanisms of GL and development of GL-based drug carriers in anti-cancer field to provide basis for the application prospects of GL. The design of novel GL-based drug delivery systems will bring new opportunities and challenges to anti-cancer therapy.

KEYWORDS

Absorption enhancer; Anti-cancer; Delivery systems; Drug combination; Glycyrrhizic acid.

Title

Glycyrrhizic Acid: A Promising Carrier Material for Anticancer Therapy

Author

Xitong Su 1 , Lei Wu 1 , Mingming Hu 1 , Wenxiang Dong 1 , Meng Xu 1 , Peng Zhang 2

Publish date

2017 Nov

PMID

30690130

Abstract

Glycyrrhizic acid is the main active component of Licorice root which has been known in traditional Chinese and Japanese medicine since ancient times. In these cultures glycyrrhizic acid (GA) is one of the most frequently used drugs. However, only in 21-st century a novel unusual property of the GA to enhance the activity of other drugs has been discovered. The review describes briefly the experimental evidences of wide spectrum of own biological activities of glycyrrhizic acid as well as discusses the possible mechanisms of the ability of GA to enhance the activity of other drugs. We have shown that due to its amphiphilic nature GA is able to form self-associates in aqueous and non-aqueous media, as well as water soluble complexes with a wide range of lipophilic drugs. The main purpose of our review is to focus reader’s attention on physicochemical studies of the molecular mechanisms of GA activity as a drug delivery system (DDS). In our opinion, the most intriguing feature of glycyrrhizic acid which might be the key factor in its therapeutic activity is the ability of GA to incorporate into the lipid bilayer and to increase the membrane fluidity and permeability. The ability of biomolecules and their aggregates to change the properties of cell membranes is of great significance, from both fundamental and practical points of view.

KEYWORDS

Complex formation; Drug delivery; Glycyrrhizic acid; Lipid membrane; Membrane permeability; Self-association; Therapeutic activity.

Title

Glycyrrhizic Acid as a Multifunctional Drug Carrier - From Physicochemical Properties to Biomedical Applications: A Modern Insight on the Ancient Drug

Author

O Yu Selyutina 1 , N E Polyakov 2

Publish date

2019 Mar 25

PMID

30659537

Abstract

Glycyrrhizic acid (GA), a triterpene isolated from the roots and rhizomes of licorice, named Glycyrrhiza glabra, is the principal bioactive ingredient of anti-viral, anti-inflammatory and hepatoprotective effects. GA has been used in the clinical treatment of hepatitis, bronchitis, gastric ulcer, AIDS (acquired immunodeficiency syndrome), certain cancers and skin diseases. It has a direct effect on anti-HBV (hepatitis B virus) via affecting the HBsAg (hepatitis B surface antigen) to extracellular secretion, improving liver dysfunction in patients with chronic hepatitis B, and ultimately improving the immune status of HBV. GA can significantly inhibit the proliferation of HIV, showing an immune activation. The clinical application of GA on the prevention and treatments of various diseases may derive from its numerous pharmacological properties. This review provides the summary of the antiviral effects of GA on research progress and mechanism in recent years.

KEYWORDS

Glycyrrhizic acid; HIV; antiviral effects; hepatitis virus; herpes virus; influenza virus..

Title

Research Progress of Glycyrrhizic Acid on Antiviral Activity

Author

Zhi-Gang Sun 1 2 , Ting-Ting Zhao 2 , Na Lu 3 , Yong-An Yang 4 , Hai-Liang Zhu 2

Publish date

2019