Catalogue Number
BD-P0089
Analysis Method
HPLC,NMR,MS
Specification
98.0%(HPLC)
Storage
-20℃
Molecular Weight
416.46
Appearance
Powder
Botanical Source
Structure Type
Lignans
Category
SMILES
CC1CC2=CC3=C(C(=C2C4=C(C(=C(C=C4C(C1C)O)OC)OC)OC)OC)OCO3
Synonyms
(8R,9S,10S)-3,4,5,19-tetramethoxy-9,10-dimethyl-15,17-dioxatetracyclo[10.7.0.02,7.014,18]nonadeca-1(19),2,4,6,12,14(18)-hexaen-8-ol
IUPAC Name
(8R,9S,10S)-3,4,5,19-tetramethoxy-9,10-dimethyl-15,17-dioxatetracyclo[10.7.0.02,7.014,18]nonadeca-1(19),2,4,6,12,14(18)-hexaen-8-ol
Density
1.2±0.1 g/cm3
Solubility
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Flash Point
301.9±30.1 °C
Boiling Point
575.6±50.0 °C at 760 mmHg
Melting Point
InChl
InChI=1S/C23H28O7/c1-11-7-13-8-16-21(30-10-29-16)22(27-5)17(13)18-14(19(24)12(11)2)9-15(25-3)20(26-4)23(18)28-6/h8-9,11-12,19,24H,7,10H2,1-6H3/t11-,12-,19+/m0/s1
InChl Key
GWDFJIBHVSYXQL-SYTFOFBDSA-N
WGK Germany
RID/ADR
HS Code Reference
2933990000
Personal Projective Equipment
Correct Usage
For Reference Standard and R&D, Not for Human Use Directly.
Meta Tag
provides coniferyl ferulate(CAS#:72960-22-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate
No Technical Documents Available For This Product.
31614780
A small and focused library of steroidal non-fused and fused pyrimidines was prepared from pregnenolone acetate and diosgenin, respectively. The key step was the cycloaddition reaction of nitrogen-containing 1,3-binucleophiles with the steroidal α,β-unsaturated ketone. Urea, thiourea and guanidine reacted in a similar manner and afforded the steroidal pyrimidines in good yields. The antiproliferative tests against human tumor cell lines gave GI50 values in the micromolar range and had no effect on healthy fibroblasts. Additional experiments indicated that the compounds did not act as P-glycoprotein substrates, thus avoiding the rise of drug resistance. The fused steroidal pyrimidinethione was selected as drug lead for further testing due to its strong antiproliferative activities within the low micromolar range.
steroids, pyrimidine, heterocycle, cycloaddition reactions, antiproliferative activity
Synthesis and Evaluation of Pyrimidine Steroids as Antiproliferative Agents
Alejandra Cortes-Percino,1 Jose Luis Vega-Baez,1 Anabel Romero-Lopez,2 Adrian Puerta,3 Penelope Merino-Montiel,1 Socorro Meza-Reyes,1 Jose M. Padron,3,* and Sara Montiel-Smith1,*
2019 Oct
31161064
In the solid state, the title compound, C15H10ClN, is disordered over two orientations with a refined occupancy ratio of 0.86 (2):0.14 (2). The crystal structure is mainly stabilized by intermolecular C—H⋯N and C—H⋯Cl hydrogen bonds, and C—H⋯π interactions. The molecules pack in columns and adjacent columns are linked by weak C—H⋯Cl interactions. The PIXEL energy analysis suggests that the intermolecular C—H⋯π interactions form a strong dimer in the major component. Hirshfeld analysis reveals that H⋯C, H⋯H, H⋯Cl and H⋯N contacts are the most important contributors to the crystal packing.
crystal structure, acrylonitrile, conjugation, hydrogen bonding, C—H⋯π interactions, PIXEL, Hirshfeld surface, two-dimensional fingerprint plots.
Quantitative analysis of weak non-covalent interactions in (Z)-3-(4-chlorophenyl)-2-phenylacrylonitrile: insights from PIXEL and Hirshfeld surface analysis
Mani Udayakumar,a Margarita Ceron,b Paulina Ceballos,b Judith Percino,b and Subbiah Thamotharana,*
2019 Apr 1;
28494773
Background
The purposes of this study, performed on a large sample of cancer patient-caregiver dyads, were: i) to simultaneously investigate, using an individualized quality of life (QoL) measure (Schedule for the Evaluation of Individual QoL, SEIQoL), the QoL domains freely expressed by cancer patients and their caregivers, and ii) to explore overlapping between the SEIQoL assessment and QoL assessment using traditional instruments.
Methods
The study employed a cross-sectional design including cancer patients who were going to receive chemotherapy treatment and their caregivers. Quality of life was assessed using condition-specific questionnaires (EORTC QLQ-C30 and CarGOQoL), generic health-related questionnaire (SF-36), and open individualized measure (SEIQoL).
Results
The final sample included 205 patient-caregiver dyads. From the SEIQoL, Family, Health, and Leisures were the most freely expressed QoL domains by patients and caregivers, but reported with different weights. Love life and financial issues were less spontaneously mentioned. The SEIQoL index was moderately correlated to the condition-specific QoL questionnaires (R lower than |0.40|) and to SF-36 (correlation coefficients: R ranging from 0.17 to 0.31).
Conclusion
Individualized QoL measures allow individuals to spontaneously express important, non-predefined domains. This study highlights the need to explore QoL using a combination of individualized questionnaires and standardized questionnaires, capturing complementary facets that patients consider important in their life.
Domains of quality of life freely expressed by cancer patients and their caregivers: contribution of the SEIQoL
Zeinab Hamidou,1,2 Karine Baumstarck,corresponding author1 Olivier Chinot,3 Fabrice Barlesi,4 Sebastien Salas,5 Tanguy Leroy,6 and Pascal Auquier1
2017
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