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Gomisin O

$717

  • Brand : BIOFRON

  • Catalogue Number : BD-P0089

  • Specification : 98.0%(HPLC)

  • CAS number : 72960-22-6

  • Formula : C23H28O7

  • Molecular Weight : 416.46

  • PUBCHEM ID : 5317808

  • Volume : 25mg

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Catalogue Number

BD-P0089

Analysis Method

HPLC,NMR,MS

Specification

98.0%(HPLC)

Storage

-20℃

Molecular Weight

416.46

Appearance

Powder

Botanical Source

Structure Type

Lignans

Category

SMILES

CC1CC2=CC3=C(C(=C2C4=C(C(=C(C=C4C(C1C)O)OC)OC)OC)OC)OCO3

Synonyms

(8R,9S,10S)-3,4,5,19-tetramethoxy-9,10-dimethyl-15,17-dioxatetracyclo[10.7.0.02,7.014,18]nonadeca-1(19),2,4,6,12,14(18)-hexaen-8-ol

IUPAC Name

(8R,9S,10S)-3,4,5,19-tetramethoxy-9,10-dimethyl-15,17-dioxatetracyclo[10.7.0.02,7.014,18]nonadeca-1(19),2,4,6,12,14(18)-hexaen-8-ol

Applications

Density

1.2±0.1 g/cm3

Solubility

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

Flash Point

301.9±30.1 °C

Boiling Point

575.6±50.0 °C at 760 mmHg

Melting Point

InChl

InChI=1S/C23H28O7/c1-11-7-13-8-16-21(30-10-29-16)22(27-5)17(13)18-14(19(24)12(11)2)9-15(25-3)20(26-4)23(18)28-6/h8-9,11-12,19,24H,7,10H2,1-6H3/t11-,12-,19+/m0/s1

InChl Key

GWDFJIBHVSYXQL-SYTFOFBDSA-N

WGK Germany

RID/ADR

HS Code Reference

2933990000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:72960-22-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

31614780

Abstract

A small and focused library of steroidal non-fused and fused pyrimidines was prepared from pregnenolone acetate and diosgenin, respectively. The key step was the cycloaddition reaction of nitrogen-containing 1,3-binucleophiles with the steroidal α,β-unsaturated ketone. Urea, thiourea and guanidine reacted in a similar manner and afforded the steroidal pyrimidines in good yields. The antiproliferative tests against human tumor cell lines gave GI50 values in the micromolar range and had no effect on healthy fibroblasts. Additional experiments indicated that the compounds did not act as P-glycoprotein substrates, thus avoiding the rise of drug resistance. The fused steroidal pyrimidinethione was selected as drug lead for further testing due to its strong antiproliferative activities within the low micromolar range.

KEYWORDS

steroids, pyrimidine, heterocycle, cycloaddition reactions, antiproliferative activity

Title

Synthesis and Evaluation of Pyrimidine Steroids as Antiproliferative Agents

Author

Alejandra Cortes-Percino,1 Jose Luis Vega-Baez,1 Anabel Romero-Lopez,2 Adrian Puerta,3 Penelope Merino-Montiel,1 Socorro Meza-Reyes,1 Jose M. Padron,3,* and Sara Montiel-Smith1,*

Publish date

2019 Oct

PMID

31161064

Abstract

In the solid state, the title compound, C15H10ClN, is disordered over two orientations with a refined occupancy ratio of 0.86 (2):0.14 (2). The crystal structure is mainly stabilized by inter­molecular C—H⋯N and C—H⋯Cl hydrogen bonds, and C—H⋯π inter­actions. The mol­ecules pack in columns and adjacent columns are linked by weak C—H⋯Cl inter­actions. The PIXEL energy analysis suggests that the inter­molecular C—H⋯π inter­actions form a strong dimer in the major component. Hirshfeld analysis reveals that H⋯C, H⋯H, H⋯Cl and H⋯N contacts are the most important contributors to the crystal packing.

KEYWORDS

crystal structure, acrylo­nitrile, conjugation, hydrogen bonding, C—H⋯π inter­actions, PIXEL, Hirshfeld surface, two-dimensional fingerprint plots.

Title

Qu­anti­tative analysis of weak non-covalent inter­actions in (Z)-3-(4-chloro­phen­yl)-2-phenyl­acrylo­nitrile: insights from PIXEL and Hirshfeld surface analysis

Author

Mani Udayakumar,a Margarita Ceron,b Paulina Ceballos,b Judith Percino,b and Subbiah Thamotharana,*

Publish date

2019 Apr 1;

PMID

28494773

Abstract

Background
The purposes of this study, performed on a large sample of cancer patient-caregiver dyads, were: i) to simultaneously investigate, using an individualized quality of life (QoL) measure (Schedule for the Evaluation of Individual QoL, SEIQoL), the QoL domains freely expressed by cancer patients and their caregivers, and ii) to explore overlapping between the SEIQoL assessment and QoL assessment using traditional instruments.

Methods
The study employed a cross-sectional design including cancer patients who were going to receive chemotherapy treatment and their caregivers. Quality of life was assessed using condition-specific questionnaires (EORTC QLQ-C30 and CarGOQoL), generic health-related questionnaire (SF-36), and open individualized measure (SEIQoL).

Results
The final sample included 205 patient-caregiver dyads. From the SEIQoL, Family, Health, and Leisures were the most freely expressed QoL domains by patients and caregivers, but reported with different weights. Love life and financial issues were less spontaneously mentioned. The SEIQoL index was moderately correlated to the condition-specific QoL questionnaires (R lower than |0.40|) and to SF-36 (correlation coefficients: R ranging from 0.17 to 0.31).

Conclusion
Individualized QoL measures allow individuals to spontaneously express important, non-predefined domains. This study highlights the need to explore QoL using a combination of individualized questionnaires and standardized questionnaires, capturing complementary facets that patients consider important in their life.

Title

Domains of quality of life freely expressed by cancer patients and their caregivers: contribution of the SEIQoL

Author

Zeinab Hamidou,1,2 Karine Baumstarck,corresponding author1 Olivier Chinot,3 Fabrice Barlesi,4 Sebastien Salas,5 Tanguy Leroy,6 and Pascal Auquier1

Publish date

2017