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Catalogue Number
BD-P0590
Analysis Method
Specification
98.0%(HPLC)
Storage
-20℃
Molecular Weight
947.16
Appearance
White powder
Botanical Source
This product is isolated and purified from the roots of Panax notoginseng (Burk.) F.H.Chen
Structure Type
Category
SMILES
CC(=CCCC(C)(C1CCC2(C1C(CC3C2(CCC4C3(CCC(C4(C)C)OC5C(C(C(C(O5)CO)O)O)O)C)C)O)C)OC6C(C(C(C(O6)COC7C(C(C(C(O7)CO)O)O)O)O)O)O)C
Synonyms
β-D-Glucopyranoside, (3β,12β)-20-[(6-O-β-D-glucopyranosyl-β-D-glucopyranosyl)oxy]-12-hydroxydammar-24-en-3-yl/Gynosaponin S/(3β,12β)-20-{[6-O-(β-D-Glucopyranosyl)-β-D-glucopyranosyl]oxy}-12-hydroxydammar-24-en-3-yl β-D-glucopyranoside/gypenoside XVII
IUPAC Name
Applications
Biotechnol Lett. 2014 Jun;36(6):1287-93. Highly selective hydrolysis for the outer glucose at the C-20 position in ginsenosides by β-glucosidase from Thermus thermophilus and its application to the production of ginsenoside F2 from gypenoside XVII.[Pubmed: 24563303]β-Glucosidase from Thermus thermophilus has specific hydrolytic activity for the outer glucose at the C-20 position in protopanaxadiol-type ginsenosides without hydrolysis of the inner glucose. METHODS AND RESULTS:The hydrolytic activity of the enzyme for Gypenoside XVII was optimal at pH 6.5 and 90 °C, with a half-life of 1 h with 3 g enzyme l(-1) and 4 g Gypenoside XVII l(-1). Under the optimized conditions, the enzyme converted the substrate Gypenoside XVII to ginsenoside F2 with a molar yield of 100 % and a productivity of 4 g l(-1) h(-1). The conversion yield and productivity of ginsenoside F2 are the highest reported thus far among enzymatic transformations.Appl Microbiol Biotechnol. 2015 Mar 31. An amino acid at position 512 in β-glucosidase from Clavibacter michiganensis determines the regioselectivity for hydrolyzing gypenoside XVII.[Pubmed: 25820645]A recombinant β-glucosidase from Clavibacter michiganensis specifically hydrolyzed the outer and inner glucose linked to the C-3 position in protopanaxadiol (PPD)-type ginsenosides and the C-6 position in protopanaxatriol (PPT)-type ginsenosides except for the hydrolysis of gypenoside LXXV (GypLXXV). The enzyme converted Gypenoside XVII (GypXVII) to gypenoside LXXV by hydrolyzing the inner glucose linked to the C-3 position. METHODS AND RESULTS:The substrate-binding residues obtained from the Gypenoside XVII-docked homology models of β-glucosidase from C. michiganensis were replaced with alanine, and the amino acid residue at position 512 was selected because of the changed regioselectivity of W512A. Site-directed mutagenesis for the amino acid residue at position 512 was performed. W512A and W512K hydrolyzed the inner glucose linked to the C-3 position and the outer glucose linked to the C-20 position of Gypenoside XVII to produce gypenoside LXXV and F2. W512R hydrolyzed only the outer glucose linked to the C-20 position of Gypenoside XVII to produce F2. However, W512E and W512D exhibited no activity for Gypenoside XVII. CONCLUSIONS:Thus, the amino acid at position 512 is a critical residue to determine the regioselectivity for the hydrolysis of Gypenoside XVII. These wild-type and variant enzymes produced diverse ginsenosides, including Gypenoside XVII, GypLXXV, F2, and compound K, from ginsenoside Rb1. To the best of our knowledge, this is the first report of the alteration of regioselectivity on ginsenoside hydrolysis by protein engineering.
Density
1.4±0.1 g/cm3
Solubility
Methanol; Water
Flash Point
566.8±34.3 °C
Boiling Point
1013.5±65.0 °C at 760 mmHg
Melting Point
InChl
InChl Key
ZRBFCAALKKNCJG-SJYBZOGZSA-N
WGK Germany
RID/ADR
HS Code Reference
Personal Projective Equipment
Correct Usage
For Reference Standard and R&D, Not for Human Use Directly.
Meta Tag
provides coniferyl ferulate(CAS#:80321-69-3) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate
No Technical Documents Available For This Product.
31867056
Out-of-hospital cardiac arrest (OHCA) is an important cause of mortality and morbidity in developed countries and remains an important public health burden. A primary cardiac aetiology is common in OHCA patients, and so patients are increasingly brought to specialist cardiac centres for consideration of coronary angiography, percutaneous coronary intervention and mechanical circulatory support. This article focuses on the management of OHCA in the cardiac catheterisation laboratory. In particular, it addresses conveyance of the OHCA patient direct to a specialist centre, the role of targeted temperature management, pharmacological considerations, provision of early coronary angiography and mechanical circulatory support.
Out-of-hospital cardiac arrest, percutaneous coronary intervention, mechanical circulatory support
Contemporary Management of Out-of-hospital Cardiac Arrest in the Cardiac Catheterisation Laboratory: Current Status and Future Directions
Nilesh Pareek,corresponding author1,,2 Peter Kordis,3 Ian Webb,1 Marko Noc,3 Philip MacCarthy,2 and Jonathan Byrne1,,2
2019 Nov 18
28529774
Treatment of an S-bridged pentanuclear AgI 3CoIII 2 complex, [Ag3{Co(L)}2]3+ [L 3- = N(CH2NHCH2CH2S−)3], in which two tris(thiolate)-type mononuclear CoIII units ([Co(L)]) are bridged by three AgI ions through S atoms, with iodomethane (CH3I) gave a new CoIII mononuclear complex, [Co(LMe2)]2+ [LMe2 − = N(CH2NHCH2CH2S−)(CH2NHCH2CH2SCH3)2], systematic name: {2-[(bis{[2-(methylsulfanyl)ethyl]aminomethyl}aminomethyl)amino]ethanethiolato}cobalt(III) bis(hexafluoridophosphate). This cationic complex was crystallized with PF6 − anions to form the title compound, [Co(LMe2)](PF6)2. In the [Co(LMe2)]2+ cation, two of three thiolate groups in [Co(L)] are methylated while one thiolate group remains unreacted. Although a total of eight stereoisomers are possible for [Co(LMe2)]2+, only a pair of enantiomers {ΛRR- and ΔSS-[Co(LMe2)]2+} are selectively formed. In the crystal, the complex cations and the PF6 − anions are connected through weak N—H⋯F, C—H⋯F and C—H⋯S hydrogen bonds into a three-dimensional structure. Two F atoms in one PF6 anion are disordered over two sets of sites with refined occupancies of 0.61 (4) and 0.39 (4) and two F atoms in the other PF6 − anion are disordered over two sets of sites with occupancies of 0.5.
crystal structure, alkylation reaction, coordination compound, thiolate complex, thioether complex, cobalt ion
Synthesis and crystallographic characterization of a mononuclear cobalt(III) complex possessing both thiolate and thioether donors: reactivity of an thiolate-bridged pentanuclear Co2Ag3 complex with iodomethane
Yosuke Fukuda,a Nobuto Yoshinari,a,* and Takumi Konnoa
2017 Apr 11
24663113
Lipid production is an important indicator for assessing microalgal species for biodiesel production. In this work, the effects of medium composition on lipid production by Scenedesmus sp. were investigated using the response surface methodology. The results of a Plackett-Burman design experiment revealed that NaHCO3, NaH2PO4·2H2O and NaNO3 were three factors significantly influencing lipid production, which were further optimized by a Box-Behnken design. The optimal medium was found to contain 3.07 g L−1 NaHCO3, 15.49 mg L−1 NaH2PO4·2H2O and 803.21 mg L−1 NaNO3. Using the optimal conditions previously determined, the lipid production (304.02 mg·L−1) increased 54.64% more than that using the initial medium, which agreed well with the predicted value 309.50 mg L−1. Additionally, lipid analysis found that palmitic acid (C16:0) and oleic acid (C18:1) dominantly constituted the algal fatty acids (about 60% of the total fatty acids) and a much higher content of neutral lipid accounted for 82.32% of total lipids, which strongly proved that Scenedesmus sp. is a very promising feedstock for biodiesel production.
optimization, lipid production, Scenedesmus sp., response surface methodology, biodiesel
Optimization of Medium Using Response Surface Methodology for Lipid Production by Scenedesmus sp.
Fangfang Yang,1,2 Lijuan Long,1 Xiumei Sun,1,2 Hualian Wu,1 Tao Li,1 and Wenzhou Xiang1,*
2014 Mar 6.