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Harmine Hydrochloride

$78

  • Brand : BIOFRON

  • Catalogue Number : BF-H2005

  • Specification : 98%

  • CAS number : 343-27-1

  • Formula : C13H13ClN2O

  • Molecular Weight : 248.71

  • PUBCHEM ID : 5359389

  • Volume : 20mg

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Catalogue Number

BF-H2005

Analysis Method

HPLC,NMR,MS

Specification

98%

Storage

2-8°C

Molecular Weight

248.71

Appearance

Yellow crystalline powder

Botanical Source

herbs of Peganum harmala L.

Structure Type

Alkaloids

Category

Standards;Natural Pytochemical;API

SMILES

CC1=NC=CC2=C1NC3=C2C=CC(=C3)OC.Cl

Synonyms

7-Methoxy-1-methyl-9H-β-carbolinhydrochlorid/7-Methoxy-1-methyl-9H-β-carboline hydrochloride/Harmine.HCL/Harmine hydrochloride hydrate/Harmine monohydrochloride/9H-Pyrido[3,4-b]indole, 7-methoxy-1-methyl-, monohydrochloride/HARMINE HYDROCHLORIDE/7-Methoxy-1-methyl-9H-β-carboline hydrochloride (1:1)/7-Methoxy-1-methyl-9H-β-carboline chlorhydrate/9H-Pyrido[3,4-b]indole, 7-methoxy-1-methyl-, hydrochloride (1:1)/Banisterine Hydrochloride

IUPAC Name

7-methoxy-1-methyl-9H-pyrido[3,4-b]indole;hydrochloride

Density

Solubility

Flash Point

139.8ºC

Boiling Point

421.4ºC at 760mmHg

Melting Point

265-270°C

InChl

InChl Key

WGK Germany

RID/ADR

HS Code Reference

2939990000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:343-27-1) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

PMID

25751815

Abstract

Types 1 and 2 diabetes affect some 380 million people worldwide. Both result ultimately from a deficiency of functional pancreatic insulin-producing beta cells. Beta cells proliferate in humans during a brief temporal window beginning around the time of birth, with peak beta cell labeling indices achieving approximately 2% in first year of life1-4. In embryonic life and after early childhood, beta cell replication rates are very low. While beta cell expansion seems an obvious therapeutic approach to beta cell deficiency, adult human beta cells have proven recalcitrant to such efforts1-8. Hence, there remains an urgent need for diabetes therapeutic agents that can induce regeneration and expansion of adult human beta cells in vivo or ex vivo. Here, we report the results of a high-throughput small molecule screen (HTS) revealing a novel class of human beta cell mitogenic compounds, analogues of the small molecule, harmine. We also define dual specificity tyrosine-regulated kinase-1a (DYRK1A) as the likely target of harmine, and the Nuclear Factors of activated T-cells (NFAT) family of transcription factors as likely mediators of human beta cell proliferation as well as beta cell differentiation. These observations suggest that harmine analogues (“harmalogs”) may have unique therapeutic promise for human diabetes therapy. Enhancing potency and beta cell specificity are important future challenges.

KEYWORDS

Biological Sciences, Drug Discovery, Drug Screening, High-Throughput Screening

Title

Induction of human pancreatic beta cell replication by inhibitors of dual specificity tyrosine regulated kinase

Author

Peng Wang, PhD,1,2 Juan-Carlos Alvarez-Perez, PhD,1,2 Dan P. Felsenfeld, PhD,3,4 Hongtao Liu, BA,1 Sharmila Sivendran, PhD,3,4 Aaron Bender, BS,1,2 Anil Kumar, PhD,1,2 Roberto Sanchez, PhD,3 Donald K. Scott, PhD,1,2,5 Adolfo Garcia-OcaNa, PhD,1,2,5 and Andrew F. Stewart, MD1,2,6

Publish date

2015 Mar 9.

PMID

32002886

Abstract

BACKGROUND:
The effects of chemical products on the nervous system have been studied by various scientists. In this work, the antiparkinsonian action of a water-soluble form of harmine hydrochloride was studied. The present studies aim to research antiparkinsonian action of the harmine hydrochloride original compound.

METHODS:
To achieve the objective of the study, the authors used haloperidol-induced catalepsy and a method of Parkinson’s syndrome (PS) induced by the MPTP (the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) neurotoxin. The experiments were performed on rats and mice which were divided into groups of 10 animals.

RESULTS:
It was established that harmine hydrochloride (HH), at a certain dose, eliminated haloperidol-induced catalepsy in rats and reduced oligokinesia and rigidity in the parkinsonism test in mice. Seven days after the experiment, the authors found the presence of rigidity in animals which had received the neurotoxin. It manifested itself in a shortened stride length compared tothis parameterin intact controls.

CONCLUSIONS:
During the study the efficacy of harmine hydrochloride was equivalent to the effects of levodopa at a certain dose, which suggested that harmine hydrochloride compensated dopamine deficiency in the brain.

KEYWORDS

Catalepsy; Motor deficiency; Neurotoxin; Oligokinesia; Rigidity

Title

Experimental study of antiparkinsonian action of the harmine hydrochloride original compound

Author

Nurmaganbetov ZS1, Arystan LI2, Muldaeva GM3, Haydargalieva LS3, Adekenov SM4.

Publish date

2019 Nov

PMID

31749766

Abstract

Several studies have demonstrated the significant antiviral, antimicrobial, antiplasmodial, antioxidative, antifungal, antimutagenic, and antitumor properties of harmine hydrochloride (HMH). The main objective of the present study was to investigate the antifungal effects and underlying mechanisms of HMH when combined with azoles to determine whether such combinations act in a synergistic manner. As a result, we found that HMH exhibits synergistic antifungal effects in combination with azoles against resistant Candida albicans (C. albicans) planktonic cells, as well as resistant C. albicans biofilm in the early stage. Antifungal potential of HMH with fluconazole was also explored in vivo using an invertebrate model. Our results suggest that HMH combined with azoles is synergistic against resistant C. albicans in vitro and in vivo. No synergy is seen with azole sensitive C. albicans strains nor with other Candida species. Such synergistic mechanisms on resistance C. albicans are involved in increasing intracellular azoles, inhibiting hyphal growth, disturbing cytosolic calcium concentration, and inducing apoptosis of resistant C. albicans cells.

Copyright © 2019 Li, Wu, Gao and Hao.

KEYWORDS

Galleria mellonella; azoles; harmine hydrochloride; resistant Candida albicans; synergistic mechanism

Title

Synergistic Effects and Mechanisms of Combined Treatment With Harmine Hydrochloride and Azoles for Resistant Candida albicans.

Author

Li X1, Wu X1, Gao Y1, Hao L1.

Publish date

2019 Oct 15;


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