Kadsura interior A .C. Smith/ the stems of Kadsura heteroclita
BL-P1761/(6R,7R,8R,14aS)-2,3-Dimethoxy-6,7-dimethyl-1-oxo-5,6,7,8-tetrahydro-1H-10,12,13-trioxabenzo[1,8]cycloocta[1,2,3-cd]-as-indacen-8-yl (2Z)-2-methyl-2-butenoate/Sarpicillina/Hetacillin-methoxymethylester/heteroclitin D/Sarpicillinum/Sarpicilline/2-Butenoic acid, 2-methyl-, (6R,7R,8R,14aS)-5,6,7,8-tetrahydro-2,3-dimethoxy-6,7-dimethyl-1-oxo-1H,14H-10,12,13-trioxabenzo[1,8]cyclooct[1,2,3-cd]-as-indacen-8-yl ester,(2Z)-/Sarpicillin/Sarpicillin (USAN)/Sarpicilline [INN-French]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
640.3±55.0 °C at 760 mmHg
HS Code Reference
Personal Projective Equipment
For Reference Standard and R&D, Not for Human Use Directly.
provides coniferyl ferulate(CAS#:140369-76-2) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate
De novo sequencing, a process to find the whole genome or the regions of a species without references, requires much higher computational power compared to mapped sequencing with references. The advent and continuous evolution of next-generation sequencing technologies further stress the demands of high-throughput processing of myriads of short DNA fragments. Recently announced sequence assemblers, such as Velvet, SOAPdenovo, and ABySS, all exploit parallelism to meet these computational demands since contemporary computer systems primarily rely on scaling the number of computing cores to improve performance. However, most of them are not tailored to exploit the full potential of these systems, leading to suboptimal performance. In this paper, we present ccTSA, a parallel sequence assembler that utilizes coverage to prune k-mers, find preferred edges, and resolve conflicts in preferred edges between k-mers. We minimize computation dependencies between threads to effectively parallelize k-mer processing. We also judiciously allocate and reuse memory space in order to lower memory usage and further improve sequencing speed. The results of ccTSA are compelling such that it runs several times faster than other assemblers while providing comparable quality values such as N50.
ccTSA: A Coverage-Centric Threaded Sequence Assembler
Jung Ho Ahn *
Cognitive dysfunction in fibromyalgia has been reported, especially memory. Anodal transcranial direct current stimulation (tDCS) over the dorsolateral prefrontal cortex (DLPFC) has been effective in enhancing this function. We tested the effects of eight sessions of tDCS and cognitive training on immediate and delayed memory, verbal fluency and working memory and its association with brain-derived neurotrophic factor (BDNF) levels. Forty females with fibromyalgia were randomized to receive eight sessions of active or sham tDCS. Anodal stimulation (2 mA) was applied over the DLPFC and online combined with a working memory training (WMT) for 20 minutes. Pre and post-treatment neurocognitive tests were administered. Data analysis on deltas considering years of education and BDNF as covariates, indicated active-tDCS + WMT significantly increased immediate memory indexed by Rey Auditory Verbal Learning Test score when compared to sham. This effect was dependent on basal BDNF levels. In addition, the model showed active stimulation increased orthographic and semantic verbal fluency scores (Controlled Oral Word Association Test) and short-term memory (Forward Digit Span). The combination of both techniques seemed to produce effects on specific cognitive functions related to short-term and long-term episodic memory and executive functions, which has clinical relevance for top-down treatment approaches in FM.
Cognitive effects of transcranial direct current stimulation combined with working memory training in fibromyalgia: a randomized clinical trial
Vinicius Souza dos Souza dos Santos,1,2 Maxciel Zortea,1,2 Rael Lopes Alves,2,3 Catia Cilene dos Santos Naziazeno,2 Júlia Schirmer Saldanha,1,2 Sandra da Conceicão Ribeiro de Carvalho,4,5 Antonio Jorge da Costa Leite,4,5 Iraci Lucena da Silva Torres,6,7 Andressa de Souza,2,8 Prisla ucker Calvetti,2 Felipe Fregni,5 and Wolnei Caumocorresponding author1,2,9
A rapid, sensitive and specific liquid chromatography tandem mass spectrometry (LC/MS/MS) method was developed and validated for the quantification of heteroclitin D in rat plasma after using gambogic acid as internal standard (IS). Chromatographic separation was done on a Thermo Hypersil GOLD column (30 × 2.1 mm, 3 µm) using a mobile phase consisting of methanol-water-formic acid (80:20:0.1, v/v/v). The mass spectrometer worked with positive electrospray ionization in multiple reaction monitoring mode, using target ions at [M + H](+) m/z 483.3 for heteroclitin D and [M + H](+) m/z 629.3 for the IS. The standard curve was linear (R(2) ≥0.995) over the concentration range 9.98-2080 ng/mL and had good back-calculated accuracy and precision. The intra- and interday precision and accuracy determined on three quality control samples (29.94, 166.4 and 1872 ng/mL) were ≤12.8 and -8.9-3.6%, respectively. The extraction recovery was ≥88.2% and the lower limit of quantification was 9.98 ng/mL. The method was successfully applied to evaluate pharmacokinetics of heteroclitin D in Sprague-Dawley rats following a single intravenous bolus injection of 2.0 mg/kg heteroclitin.
Copyright © 2014 John Wiley & Sons, Ltd.
LC/MS/MS; heteroclitin D; pharmacokinetics; rat plasma
Quantification of heteroclitin D in rat plasma: validation of an LC/MS/MS method and its application in a preclinical pharmacokinetic study.
Zhang F1, Zhang N, Pang L, Tan Y, Xu H.