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Hydrocortisone

$43

  • Brand : BIOFRON

  • Catalogue Number : BF-H3022

  • Specification : 98%

  • CAS number : 50-23-7

  • Formula : C21H30O5

  • Molecular Weight : 362.46

  • Volume : 50mg

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Catalogue Number

BF-H3022

Analysis Method

HPLC,NMR,MS

Specification

98%

Storage

2-8°C

Molecular Weight

362.46

Appearance

powder

Botanical Source

Structure Type

Others

Category

SMILES

CC12CCC(=O)C=C1CCC3C2C(CC4(C3CCC4(C(=O)CO)O)C)O

Synonyms

IUPAC Name

Density

1.3±0.1 g/cm3

Solubility

Soluble to 100 mM in DMSO and to 25 mM in ethanol

Flash Point

310.4±26.6 °C

Boiling Point

566.5±50.0 °C at 760 mmHg

Melting Point

211-214 °C(lit.)

InChl

InChI=1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1

InChl Key

JYGXADMDTFJGBT-VWUMJDOOSA-N

WGK Germany

RID/ADR

HS Code Reference

2937290000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:50-23-7) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

PMID

32580144

Abstract

Objective: Patients with adrenal insufficiency (AI) suffer from impaired quality of life and are at risk of adrenal crisis (AC) despite established replacement therapy. Patient education is regarded an important measure for prevention of AC and improvement of AI management. A standardized education programme was elaborated for patients with chronic AI in Germany.

Design: Longitudinal, prospective, questionnaire-based, multi-centre study.

Methods: During 2-h sessions, patients (n = 526) were provided with basic knowledge on AI, equipped with emergency cards and sets and trained in self-injection of hydrocortisone. To evaluate the education programme, patients from eight certified centres completed questionnaires before, immediately after and 6-9 months after training.

Results: 399 completed data sets were available for analysis. Questionnaire score-values were significantly higher after patient education, indicating successful knowledge transfer (baseline: 17 ± 7.1 of a maximum score of 29; after training: 23 ± 4.2; P < 0.001), and remained stable over 6-9 months. Female sex, younger age and primary cause of AI were associated with higher baseline scores; after education, age, cause of AI and previous adrenal crisis had a significant main effect on scores. 91% of patients would dare performing self-injection after training, compared to 68% at baseline. An improvement of subjective well-being through participation in the education programme was indicated by 95% of the patients 6-9 months after participation.

Conclusion: Patient group education in chronic AI represents a helpful tool for the guidance of patients, their self-assurance and their knowledge on prevention of adrenal crises. Repeated training and adaptation to specific needs, for example, of older patients is needed.

Title

Standardised patient education in adrenal insufficiency: a prospective multi-centre evaluation

Author

Stephanie Burger-Stritt 1, Annemarie Eff 1, Marcus Quinkler 2, Tina Kienitz 3, Bettina Stamm 4, Holger S Willenberg 5, Gesine Meyer 6, Johannes Klein 7, Nicole Reisch 8, Michael Droste 9, Stefanie Hahner 1

Publish date

2020 Aug;

PMID

32555949

Abstract

The coronavirus disease 2019 (COVID-19) is an emerging pandemic challenge. Acute respiratory distress syndrome (ARDS) in COVID-19 is characterized by a severe cytokine storm. Patients undergoing glucocorticoid (GC) replacement therapy for adrenal insufficiency (AI) represent a highly vulnerable group that could develop severe complications due to the SARS-CoV-2 infection. In this review, we highlight the strategies to avoid an adrenal crisis in patients with AI and COVID-19. Adrenal crisis is a medical emergency and an important cause of death. Once patients with AI present symptoms of COVID-19, the dose of GC replacement therapy should be immediately doubled. In the presence of any emergency warning signs or inability to administer oral GC doses, we recommend that patients should immediately seek Emergency services to evaluate COVID-19 symptoms and receive 100 mg hydrocortisone by intravenous injection, followed by 50 mg hydrocortisone intravenously every 6 h or 200 mg/day by continuous intravenous infusion.

Title

Adrenal Insufficiency and Glucocorticoid Use During the COVID-19 Pandemic

Author

Madson Q Almeida 1 2, Berenice B Mendonca 1

Publish date

2020 Jun 12;

PMID

32535969

Abstract

Background: Early puberty is associated with higher than average risk of antisocial behaviour, both in girls and boys. Most studies of such association, however, have focused on psychosocial mediating and moderating factors. Few refer to coterminous hormonal measures.

Aim: The aim of this review is to consider the role of hormonal markers as potential mediating or moderating factors between puberty timing and antisocial behaviour.

Method: A systematic literature search was conducted searching Medline, Embase, Web of Science, Scopus, Psycinfo, Cochrane and Google Scholar.

Results: Just eight studies were found to fit criteria, all cross-sectional. Measurements were too heterogeneous to allow meta-analysis. The most consistent associations found were between adrenal hormones-both androgens and cortisol-which were associated with early adrenarche and antisocial behaviours in girls and later adrenarche and antisocial behaviour in boys.

Conclusions: The findings from our review suggest that longitudinal studies to test bidirectional hormone-behaviour associations with early or late puberty would be worthwhile. In view of the interactive processes between hypothalamic-pituitary-adrenal and hypothalamic-pituitary-gonadal axes, integrated consideration of the hormonal end products is recommended.

© 2020 John Wiley & Sons Ltd.

Title

Endocrine markers of puberty timing and antisocial behaviour in girls and boys

Author

Philip Jules Simon Michielsen 1 2, Sabine Judith Roza 1 3, Hjalmar Johan Carel van Marle 4

Publish date

2020 Jun;


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