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Hydroquinone

$52

  • Brand : BIOFRON

  • Catalogue Number : BD-P0260

  • Specification : 98.0%(HPLC)

  • CAS number : 123-31-9

  • Formula : C6H6O2

  • Molecular Weight : C6H6O2

  • Volume : 100mg

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Catalogue Number

BD-P0260

Analysis Method

Specification

98.0%(HPLC)

Storage

2-8°C

Molecular Weight

C6H6O2

Appearance

Botanical Source

Structure Type

Simple Phenolic Compounds

Category

SMILES

Synonyms

IUPAC Name

Applications

Density

1.3±0.1 g/cm3

Solubility

Flash Point

141.6±14.4 °C

Boiling Point

286.0±0.0 °C at 760 mmHg

Melting Point

172-175 °C(lit.)

InChl

InChl Key

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:123-31-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

31950744

Abstract

The formation of growth-mediated structures from gold nanoparticle seeds was studied in the presence of amine-modified single-strand DNA sequences and reducing agents such as hydroxylamine and hydroquinone. In the case of hydroxylamine, spherical gold nanoparticle seeds (0.45 nM) were incubated with amine-modified single-strand DNA probes PMR (amine-5′-ACATCAGT-3′) and PML (amine-5′-GATAAGCT-3′), which resulted in gold nanoflowers and nanospheres, respectively. When the concentration of the nanoparticle seeds was varied (0.15-0.45 nM), only the PMR sequence showed growth-mediated development of gold nanoflowers. The size of the gold nanoparticles obtained is independent of the seed concentration for both PMR and PML sequences. In contrast, in the presence of the reducing agent hydroquinone, the growth processes are identical in for both the sequences. At a lower seed concentrations (0.15 nM), gold nanoflowers of larger size were observed for both sequences, whereas at higher seed concentrations (0.45 nM), much smaller gold nanospheres resulted. The formation and stability of nanoflowers and nanospheres for PMR and PML with hydroxylamine-based reduction were further studied in detail with diverse controlled amine-modified (5′-, 3′- and both end-modified) and non-modified DNA sequences with other mutants of these two sequences.

KEYWORDS

DNA structures; gold nanoparticles; growth factors; nanoflowers; reducing agents.

Title

Formation of Growth-Mediated Gold Nanoflowers: Roles of the Reducing Agent and Amine-Modified, Single-Strand DNA Sequences

Author

Shahbaz Ahmad Lone 1, Kalyan K Sadhu 1

Publish date

2019 Jan

PMID

31899212

Abstract

Benzene exposure is a risk factor of acute myeloid leukemia (AML), during such carcinogenesis long non-coding RNAs (lncRNAs) are important epigenetic regulators. HOTAIRM1 (HOXA transcript antisense RNA, myeloid-specific 1) plays an indispensable role in the development of AML. Hydroquinone (HQ) is one major metabolite of benzene and its ideal replacement in toxicology research. But the influence of benzene or HQ on HOTAIRM1 expression in AML associated pathway is still unclear. In the TK6 cells with short-term exposure to HQ (HQ-ST cells) or long term HQ exposure induced malignant transformed TK6 cells (HQ-MT cells), the relationship between DNMT3b and HOTAIRM1 was explored. Comparing to counterparts, HOTAIRM1 expression was increased firstly and then decreased in HQ-ST cells, and definitely decreased in HQ-MT cells; while the expression change tendency of DNMT3b was in contrast to that of HOTAIRM1. Moreover, the average HOTAIRM1 expression of 17 paired workers being exposed to benzene within 1.5 years was increased, but that of the remaining 92 paired workers with longer exposure time was decreased. Furthermore, in 5-AzaC (DNA methyltransferase inhibitor) or TSA (histone deacetylation inhibitor) treated HQ-MT cells, the expression of HOTAIRM1 was restored by reduced DNA promoter methylation levels. HQ-MT cells with DNMT3b knockout by CRISPR/Cas9 displayed the promoter hypomethylation and the increase of HOTAIRM1, also confirmed in benzene exposure workers. These suggest that long term exposure to HQ or benzene might induce the increase of DNMT3b expression and the promoter hypermethylation to silence the expression of HOTAIRM1, a possible tumor-suppressor in the AML associated carcinogenesis pathway.

KEYWORDS

Benzene; DNA methylation; DNMT3b; HOTAIRM1; Hydroquinone.

Title

Up-regulation of DNMT3b Contributes to HOTAIRM1 Silencing via DNA Hypermethylation in Cells Transformed by Long-Term Exposure to Hydroquinone and Workers Exposed to Benzene

Author

Haiqiao Zhang 1, Qian Yuan 2, Zhijie Pan 2, Xiaoxuan Ling 2, Qiang Tan 3, Minhua Wu 4, Dongyan Zheng 2, Peien Xie 2, Daxiao Xie 2, Linhua Liu 5

Publish date

2020 Apr 1

PMID

31808287

Abstract

Electrofermentation actively regulates the bacterial redox state, which is essential for bioconversion and has been highlighted as an effective method for further improvements of the productivity of either reduced or oxidized platform chemicals. 1,3-Propanediol (1,3-PDO) is an industrial value-added chemical that can be produced from glycerol fermentation. The bioconversion of 1,3-PDO from glycerol requires additional reducing energy under anoxic conditions. The cathode-based conversion of glycerol to 1,3-PDO with various electron shuttles (2-hydroxy-1,4-naphthoquinone, neutral red, and hydroquinone) using Klebsiella pneumoniae L17 was investigated. The externally poised potential of -0.9 V vs. Ag/AgCl to the cathode increased 1,3-PDO (35.5±3.1 mm) production if 100 μm neutral red was used compared with non-bioelectrochemical system fermentation (23.7±2.4 mm). Stoichiometric metabolic flux and transcriptional analysis indicated a shift in the carbon flux toward the glycerol reductive pathway. The homologous overexpression of glycerol dehydratase (DhaB) and 1,3-PDO oxidoreductase (DhaT) enzymes synergistically enhanced 1,3-PDO conversion (39.3±0.8 mm) under cathode-driven fermentation. Interestingly, a small current uptake (0.23 mmol of electrons) caused significant metabolic flux changes with a concomitant increase in 1,3-PDO production. This suggests that both an increase in 1,3-PDO production and regulation of the cellular metabolic pathway are feasible by electrode-driven control in cathodic electrofermentation.

KEYWORDS

1,3-propanediol; bacteria; electrochemical conversion; electrofermentation; metabolic shift.

Title

Small Current but Highly Productive Synthesis of 1,3-Propanediol From Glycerol by an Electrode-Driven Metabolic Shift in Klebsiella Pneumoniae L17

Author

Changman Kim 1 2, Jae Hyeon Lee 1, Jiyun Baek 1, Da Seul Kong 1, Jeong-Geol Na 3, Jinwon Lee 3, Eric Sundstrom 4, Sunghoon Park 5, Jung Rae Kim 1

Publish date

2020 Feb 7