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Hypoxanthine

$45

  • Brand : BIOFRON

  • Catalogue Number : AV-P11503

  • Specification : 98%

  • CAS number : 68-94-0

  • Formula : C5H4N4O

  • Molecular Weight : 136.11

  • PUBCHEM ID : 135398638

  • Volume : 100mg

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Catalogue Number

AV-P11503

Analysis Method

HPLC,NMR,MS

Specification

98%

Storage

2-8°C

Molecular Weight

136.11

Appearance

Off-white crystalline powder

Botanical Source

Structure Type

Nucleosides/Nucleotide

Category

Standards;Natural Pytochemical;API

SMILES

C1=NC2=C(N1)C(=O)NC=N2

Synonyms

3,9-Dihydro-6H-purin-6-on/1,7-Dihydro-6H-purin-6-on/6-Oxopurine/1,7-Dihydro-6H-purin-6-one/7H-Purin-6-ol/PURIN-6-OL/Hypexanthine/SARKIN/SARCINE/Hypoxathine/3,9-Dihydro-6H-purin-6-one/Hypoxanthine/Purine-6-ol/6-oxypurine/Sarkine/Hypoxanthin/6-Hydroxypurine/1H,7H-Hypoxanthine/1,7-dihydro-purin-6-one/1,7-Dihydro-6H-purine-6-one

IUPAC Name

1,7-dihydropurin-6-one

Density

1.7±0.1 g/cm3

Solubility

Aqueous base; DMSO

Flash Point

287.0±24.6 °C

Boiling Point

551.0±30.0 °C at 760 mmHg

Melting Point

>300 °C(lit.)

InChl

InChl Key

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:68-94-0) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

27888108

Abstract

Endothelial cell injury and dysfunction caused by reactive oxygen species (ROS) are implicated in the pathogenesis of vascular diseases. ROS are generated and hypoxanthine is degraded by xanthine oxidase. Smoking and alcohol consumption are associated with an increased level of hypoxanthine. We aimed to study the direct role of hypoxanthine in endothelial dysfunction in human umbilical vascular endothelial cells (HUVECs). Hypoxanthine induced cell death and production of ROS. Furthermore, hypoxanthine induced apoptosis through regulation of protein expression related to apoptosis. When cells were pretreated with N-acetylcysteine or a pancaspase inhibitor (Z-VAD-fmk) and stimulated with hypoxanthine, Z-VAD-fmk and N-acetylcysteine prevented hypoxanthine-induced apoptosis by inhibiting the ROS production and caspase pathway. Thus, an increased extracellular concentration of hypoxanthine induces endothelial dysfunction through ROS production and regulates expression of apoptosis-related proteins in HUVECs. These effects are expected to be associated with some vascular diseases.

Copyright ? 2016 Elsevier Inc. All rights reserved.

KEYWORDS

Apoptosis; Endothelial cell; Hypoxanthine; Reactive oxygen species

Title

Hypoxanthine causes endothelial dysfunction through oxidative stress-induced apoptosis.

Author

Kim YJ1, Ryu HM2, Choi JY3, Cho JH3, Kim CD2, Park SH2, Kim YL4.

Publish date

2017 Jan 22

PMID

28820221

Abstract

Intramolecular proton transfer of hypoxanthine, induced by application of a laser on the surface of a bare noble nanomaterial, was monitored in real time using surface-enhanced Raman spectroscopy (SERS). This monitoring demonstrated the dependence of the reaction on the identity of the nanomaterial and on the laser power density. The results pave the way for monitoring the proton transfer reaction in various relevant fields. In addition, we observed the presence of the proton transfer phenomenon of hypoxanthine in serum, providing a way to avoid the effect of proton transfer and hence achieve more reliable spectra of sera for clinical diagnosis.

Title

Real-time monitoring of plasmon-induced proton transfer of hypoxanthine in serum.

Author

Zhou B1, Li S, Tang X, Li P, Cao X, Yu B, Yang L, Liu J.

Publish date

2017 Aug 31

PMID

28583948

Abstract

In recent years, biofilms have become a central subject of research in the fields of microbiology, medicine, agriculture, and systems biology, among others. The sociomicrobiology of multispecies biofilms, however, is still poorly understood. Here, we report a screening system that allowed us to identify soil bacteria which induce architectural changes in biofilm colonies when cocultured with Bacillus subtilis We identified the soil bacterium Lysinibacillus fusiformis M5 as an inducer of wrinkle formation in B. subtilis colonies mediated by a diffusible signaling molecule. This compound was isolated by bioassay-guided chromatographic fractionation. The elicitor was identified to be the purine hypoxanthine using mass spectrometry and nuclear magnetic resonance (NMR) spectroscopy. We show that the induction of wrinkle formation by hypoxanthine is not dependent on signal recognition by the histidine kinases KinA, KinB, KinC, and KinD, which are generally involved in phosphorylation of the master regulator Spo0A. Likewise, we show that hypoxanthine signaling does not induce the expression of biofilm matrix-related operons epsABCDEFGHIJKLMNO and tasA-sipW-tapA Finally, we demonstrate that the purine permease PbuO, but not PbuG, is necessary for hypoxanthine to induce an increase in wrinkle formation of B. subtilis biofilm colonies. Our results suggest that hypoxanthine-stimulated wrinkle development is not due to a direct induction of biofilm-related gene expression but rather is caused by the excess of hypoxanthine within B. subtilis cells, which may lead to cell stress and death.IMPORTANCE Biofilms are a bacterial lifestyle with high relevance regarding diverse human activities. Biofilms can be beneficial, for instance, in crop protection. In nature, biofilms are commonly found as multispecies communities displaying complex social behaviors and characteristics. The study of interspecies interactions will thus lead to a better understanding and use of biofilms as they occur outside laboratory conditions. Here, we present a screening method suitable for the identification of multispecies interactions and showcase L. fusiformis as a soil bacterium that is able to live alongside B. subtilis and modify the architecture of its biofilms.

Copyright ? 2017 American Society for Microbiology.

KEYWORDS

Bacillus subtilis; Lysinibacillus fusiformis; biofilms; hypoxanthine; interaction

Title

Lysinibacillus fusiformis M5 Induces Increased Complexity in Bacillus subtilis 168 Colony Biofilms via Hypoxanthine.

Author

Gallegos-Monterrosa R1, Kankel S1, Gotze S2, Barnett R2, Stallforth P3, Kovacs aT4,5.

Publish date

2017 Oct 17


Description :

Hypoxanthine, a purine derivative, is a potential free radical generator and could be used as an indicator of hypoxia.