This product is isolated and purified from the rhizomes of Belamcanda chinensis (L.) DC.
Cancer chemopreventive in vitro activities of isoflavones isolated from Iris germanica.[Pubmed: 12567273 ]Planta Med. 2003 Jan;69(1):15-20. METHODS AND RESULTS:Six known isoflavones were isolated from the rhizomes of Iris germanica, and were established by UV, MS and NMR techniques as irisolidone (1), irisolidone 7-O-alpha-D-glucoside (1a), Irigenin (2), irilone (3), iriflogenin (4), and iriskashmirianin (5). These compounds were examined for their cancer chemopreventive potential. They were shown to be potent inhibitors of cytochrome P450 1A activity with IC 50 values in the range 0.25-4.9 microM. The isoflavones 2, 3 and 5 displayed moderate activity as inducers of NAD(P)H:quinone reductase (QR) in cultured mouse Hepa 1c1c7 cells, with CD values (concentration required to double the specific activity of QR) of 3.5-16.7 microM, whereas weak activity was observed with compounds 4 and 5 in the radical (DPPH) scavenging bioassay (IC 50 values 89.6 and 120.3 microM, respectively). CONCLUSIONS:With respect to anti-tumor promoting potential based on anti-inflammatory mechanisms, none of the compounds demonstrated significant activity in the concentration range tested.
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
646.1ºC at 760mmHg
HS Code Reference
Personal Projective Equipment
For Reference Standard and R&D, Not for Human Use Directly.
provides coniferyl ferulate(CAS#:548-76-5) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate
ESICM LIVES 2016: part two Milan, Italy. 1-5 October 2016
2016 Sep 29
Multiple vertebral compression fractures in a patient treated with corticosteroids for cystic fibrosis
David Yen, MD* and Douglas Hedden, MD†
To study factors that affect femorotibial (F-T) alignment after valgus closing wedge tibial osteotomy.
A review of standardized standing radiographs. Femorotibial alignment was measured 1 year postoperatively for over- and under-correction. Changes in F-T alignment and in tibial plateau angle were measured.
An urban hospital and orthopedic clinic.
Eighty-two patients with osteoarthritis and varus femorotibial alignment underwent valgus closing wedge tibial osteotomy. Patients having a diagnosis of inflammatory arthritis or a prior osteotomy about the knee were excluded.
A 1° wedge removed from the tibia resulted in an average correction of F-T alignment of 1.2°. A knee that had increased valgus orientation of the distal femur had a greater degree of correction, averaging 1.46° in F-T alignment per degree of tibial wedge. This resulted in excessive postoperative valgus alignment for some patients who had increased valgus tilt of the distal femur. Optimal F-T alignment of 6° to 14° of valgus occurred when the postoperative tibial inclination was 4° to 8° of valgus.
There was a trend for knees with increased valgus orientation of the distal femur to have greater correction in F-T alignment after tibial osteotomy, likely because of a greater opening up of the medial joint space during stance. Surgeons need to account for this in their preoperative planning.
Optimizing femorotibial alignment in high tibial osteotomy
John Rudan, MD , Mark Harrison, MD , and Michael A Simurda, MD