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  • Brand : BIOFRON

  • Catalogue Number : BD-P0848

  • Specification : 98.0%(HPLC)

  • CAS number : 54081-48-0

  • Formula : C21H22O11

  • Molecular Weight : 450.4

  • PUBCHEM ID : 316844

  • Volume : 25mg

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Catalogue Number


Analysis Method






Molecular Weight




Botanical Source

Engelhardtia roxburghiana Wall.leaf

Structure Type










Antimicrobial activity against Streptococcus sobrinus and glucosyltransferase inhibitory activity of taxifolin and some flavanonol rhamnosides from kempas (Koompassia malaccensis) extracts PUMID/DOI:DOI: 10.1007/s10086-009-1026-4? J. Wood Sci., 2009, 55(4):308-13. Twenty plant materials collected from the islands of Java and Kalimantan in Indonesia were extracted with 50% aqueous ethanol (crude extract). The crude extracts were assayed for antimicrobial activities against Streptococcus sobrinus and for glucosyltransferase (GTase) inhibition. Fourteen extracts inhibited the growth of S. sobrinus by more than 50% and six extracts inhibited GTase activity by more than 50% at a concentration of 100 ??g/ml. Koompassia malaccensis (kempas) extracts showed 90% depression of S. sobrinus growth and 80% inhibition of GTase activity at a concentration of 100 ??g/ml. Kempas crude extracts were subjected to column chromatography using Sephadex LH-20 and then preparative high-performance liquid chromatography to isolate four compounds A, B, C, and D. These compounds were identified as taxifolin and the flavanonol rhamnoside isomers neoastilbin, astilbin, and isoastilbin, respectively, from ?1H and ?1?3C nuclear magnetic resonance (NMR) spectra and other two-dimensional NMR techniques (COSY, HMBC, and HMQC). Each compound depressed the growth of S. sobrinus over a concentration range of 9.3242.7 ??g/ml and showed GTase inhibitory activity with ICa??a?? values in the range 27.4a??57.3 ??g/ml. Taxifolin and flavanonol rhamnoside isomers isolated for the first time from kempas could be potent compounds for preventing dental caries. Anti-acne and Tyrosinase Inhibition Properties of Taxifolin and Some Flavanonol Rhamnosides from Kempas ( Koompassia malaccensis ) PUMID/DOI:无 Wood Research Journal ,2010, 1(1):45-9. Taxifolin (1) and some flavanonol rhamnosides (neoastilbin (2), astilbin (3), and Isoastilbin (4)) have been isolated from kempas (Koompassia malaccensis). Our previous research about antimicrobial activity against Streptococcus sobrinus and glucosyltransferase inhibitory activity of these compounds have been reported. Now, we carried out the antiacne and tyrosinase inhibition properties of all four compounds. Antimicrobial against Propionibacterium acnes, P. acnes lipase inhibitory activity and antioxidant activity were established for anti-acne activity. Tyrosinase inhibition property was measured using L-tyrosine and L-DOPA as substrate. The results for anti-acne showed that no antimicrobial activity against P. acnes for all compounds, the best lipase inhibition properties showed on compound 4 with IC50 about 1.36 g/ml, and % inhibition for antioxidant at concentration 10 g/ml are 31.16, 25.64, 28.47, and 31.01% respectively. Tyrosinase inhibition of compound 1 at concentration 1 mg/ml is 24.12% for monophenolase and 5.18% for diphenolase. Compound 2 has tyrosinase inhibition about 25.95% (monophenolase) and 14.18% (diphenolase) at concentration 1 mg/ml. Compound 3 has tyrosinase inhibition about 27.17% (monophenolase) and 6.23% (diphenolase) at same concentration, while compound 4 has tyrosinase inhibition about 11.17% (monophenolase) and 9.75% (diphenolase).


1.7±0.1 g/cm3


Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

Flash Point

282.9±27.8 °C

Boiling Point

801.1±65.0 °C at 760 mmHg

Melting Point



InChl Key


WGK Germany


HS Code Reference


Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:54081-48-0) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.




Astilbin (ASB), a dihydroflavonol glycoside, is widely found in a variety of plants and in functional foods and acts as a powerful antioxidant. The aim of this study was to investigate the underlying mechanisms involved in the antagonistic effects of ASB on cadmium (Cd)-induced necroptosis in chicken peripheral blood lymphocytes. Peripheral blood lymphocytes were aseptically collected from Roman white hens and then randomly divided into five groups: the control group was incubated without additional reagents, while the other groups were incubated with Cd, ASB, a combination of Cd and ASB, and 0.1% DMSO. After a 24 h treatment, cell samples were collected. The results showed that some morphological changes consistent with necroptosis were observed in the Cd-treated groups, suggesting the occurrence of necroptosis. Simultaneously, antioxidant activity markers (CAT, SOD, GSH, GSH-px, and T-AOC) decreased and indicators of oxidative stress (MDA, iNOS, NO, H2O2, ·OH and ROS) increased. The production of ROS induced the activation of the PI3K/Akt signaling pathway, as the expression levels of PI3K, Akt and PDK1 were significantly elevated. Additionally, the expression levels of RIPK3, RIPK1, MLKL, TAK1, TAB2 and TAB3 were increased and that of Caspase-8 was decreased, which could cause the necroptosis. However, the most important our results was that ASB supplements remarkably attenuated the Cd-induced effects. We conclude that the Cd treatment promoted an imbalance of the antioxidant status and activated the PI3K/Akt pathway, leading to necroptosis in chicken peripheral blood lymphocytes, and that ASB was able to partially ameliorate the effect of Cd-induced necroptosis.


Astilbin; Cadmium; Lymphocytes; Necroptosis; Oxidative stress; PI3K/Akt pathway.


Astilbin protects chicken peripheral blood lymphocytes from cadmium-induced necroptosis via oxidative stress and the PI3K/Akt pathway


Chi Xin 1, Shi Guangliang 1, Zhang Qing 1, Liu Qingqing 1, Yin Hang 1, Zhang Yiming 1, Li Shu 2

Publish date

2020 Mar 1




The quality of a wine largely depends on the balance between its sourness, bitterness and sweetness. Recently, epi-dihydrophaseic acid-3′-O-β-glucopyranoside (epi-DPA-G) and astilbin, two molecules obtained from grapes, have been shown to contribute notably to the sweet taste of dry wines. To study the parameters likely to affect their concentration, a new method was developed and optimized by LC-FTMS. Three gradients and five C18 columns were tested. Good results in terms of linearity (r2 > 0.9980), repeatability (RSD ≤ 3%), recovery (≥89%) and LOQ (≤20 µg.L-1) were obtained. The method was used to screen epi-DPA-G and astilbin in red wines of several vintages over one century. Both compounds were detected in all wines at concentrations varying from 1.2 to 14.7 mg/L for epi-DPA-G and from 0.5 to 42.6 mg/L for astilbin. Therefore, this new method can be used to quantify epi-DPA-G and astilbin reliably in wine.


Astilbin; Method validation; Orbitrap; Sweetness; Wine; epi-DPA-G.


Development and validation of an LC-FTMS method for quantifying natural sweeteners in wine


Syntia Fayad 1, Blandine N Cretin 1, Axel Marchal 2

Publish date

2020 May 1;




Engelhardtia chrysolepis Hance (ECH) is a perennial plant used in traditional medicine. A major active ingredient of ECH is astilbin (ASB), which has recently been shown to have neuroprotective effects as well as to affect catecholamine neurotransmissions in brain areas such as the prefrontal cortex. In this study, we investigated the effects of ECH and ASB on long-term memory in mice using a battery of behavioral tests. Acute ECH treatments dose-dependently facilitated nonspatial, but not spatial, memory. ECH treatments also upregulated expression of tyrosine hydroxylase, the enzyme mediating catecholamine synthesis, in neuroblastoma cell culture. Acute ASB treatments similarly improved nonspatial memory, whereas chronic ASB treatments improved both nonspatial and spatial memory. In accordance with such behavioral effects, the increased ratio of tissue concentrations of dopamine metabolites over dopamine in striatal regions was observed in mice with chronic ASB treatments. These results suggest that ECH and its active ingredient ASB may facilitate long-term memory by modulating catecholamine transmission.


The effects of Engelhardtia chrysolepis Hance on long-term memory and potential dopamine involvement in mice


So-Yeon Jeon 1, Na-Hyun Kim 1, Yu-Jeong Kim 1, Kyung-A Lee 1, Yukiori Goto 2, Young-A Lee 1

Publish date

2019 Oct;