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Isobergapten

$300

  • Brand : BIOFRON

  • Catalogue Number : BF-I4002

  • Specification : 98%(HPLC)

  • CAS number : 482-48-4

  • Formula : C12H8O4

  • Molecular Weight : 216.19

  • PUBCHEM ID : 68082

  • Volume : 10mg

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Catalogue Number

BF-I4002

Analysis Method

HPLC,NMR,MS

Specification

98%(HPLC)

Storage

2-8°C

Molecular Weight

216.19

Appearance

White crystalline powder

Botanical Source

fruits of Citrus medica L.

Structure Type

Phenylpropanoids

Category

Standards;Natural Pytochemical;API

SMILES

COC1=C2C=CC(=O)OC2=C3C=COC3=C1

Synonyms

2H-Furo[2,3-h]-1-benzopyran-2-one, 5-methoxy-/5-Methoxy-2H-furo[2,3-h]-1-benzopyran-2-one/isobergaptene/2H-Furo(2,3-h)-1-benzopyran-2-one, 5-methoxy-/Isobergapten,5-Methoxy-7,8:5',4'-furocumarin/Isobergapten/5-Methoxy-2H-furo(2,3-h)-1-benzopyran-2-one/5-Methoxy-2H-furo[2,3-h]chromen-2-one

IUPAC Name

5-methoxyfuro[2,3-h]chromen-2-one

Applications

Density

1.368

Solubility

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

Flash Point

203.2±28.7 °C

Boiling Point

412.4±45.0 °C at 760 mmHg

Melting Point

224 ºC

InChl

InChI=1S/C12H8O4/c1-14-9-6-10-8(4-5-15-10)12-7(9)2-3-11(13)16-12/h2-6H,1H3

InChl Key

AJSPSRWWZBBIOR-UHFFFAOYSA-N

WGK Germany

RID/ADR

HS Code Reference

2932990000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:482-48-4) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

PMID

25009251

Abstract

SNX-482, a peptide toxin isolated from tarantula venom, has become widely used as an inhibitor of Cav2.3 voltage-gated calcium channels. Unexpectedly, we found that SNX-482 dramatically reduced the A-type potassium current in acutely dissociated dopamine neurons from mouse substantia nigra pars compacta. The inhibition persisted when calcium was replaced by cobalt, showing that it was not secondary to a reduction of calcium influx. Currents from cloned Kv4.3 channels expressed in HEK-293 cells were inhibited by SNX-482 with an IC50 of <3 nm, revealing substantially greater potency than for SNX-482 inhibition of Cav2.3 channels (IC50 20-60 nm). At sub-saturating concentrations, SNX-482 produced a depolarizing shift in the voltage dependence of activation of Kv4.3 channels and slowed activation kinetics. Similar effects were seen on gating of cloned Kv4.2 channels, but the inhibition was less pronounced and required higher toxin concentrations. These results reveal SNX-482 as the most potent inhibitor of Kv4.3 channels yet identified. Because of the effects on both Kv4.3 and Kv4.2 channels, caution is needed when interpreting the effects of SNX-482 on cells and circuits where these channels are present.

KEYWORDS

Cav2.3, IA, ICK toxin, Kv4.2, Kv4.3, tarantula toxin

Title

Inhibition of A-Type Potassium Current by the Peptide Toxin SNX-482

Author

Tilia Kimm and Bruce P. Beancorresponding author

Publish date

2014 Jul 9

Title

ESICM LIVES 2016: part twoMilan, Italy. 1-5 October 2016

Publish date

2016 Sep 29

Title

ESICM LIVES 2016: part threeMilan, Italy. 1-5 October 2016

Publish date

2016 Sep 29