White crystalline powder
fruits of Citrus medica L.
2H-Furo[2,3-h]-1-benzopyran-2-one, 5-methoxy-/5-Methoxy-2H-furo[2,3-h]-1-benzopyran-2-one/isobergaptene/2H-Furo(2,3-h)-1-benzopyran-2-one, 5-methoxy-/Isobergapten,5-Methoxy-7,8:5',4'-furocumarin/Isobergapten/5-Methoxy-2H-furo(2,3-h)-1-benzopyran-2-one/5-Methoxy-2H-furo[2,3-h]chromen-2-one
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
412.4±45.0 °C at 760 mmHg
HS Code Reference
Personal Projective Equipment
For Reference Standard and R&D, Not for Human Use Directly.
provides coniferyl ferulate(CAS#:482-48-4) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate
SNX-482, a peptide toxin isolated from tarantula venom, has become widely used as an inhibitor of Cav2.3 voltage-gated calcium channels. Unexpectedly, we found that SNX-482 dramatically reduced the A-type potassium current in acutely dissociated dopamine neurons from mouse substantia nigra pars compacta. The inhibition persisted when calcium was replaced by cobalt, showing that it was not secondary to a reduction of calcium influx. Currents from cloned Kv4.3 channels expressed in HEK-293 cells were inhibited by SNX-482 with an IC50 of <3 nm, revealing substantially greater potency than for SNX-482 inhibition of Cav2.3 channels (IC50 20-60 nm). At sub-saturating concentrations, SNX-482 produced a depolarizing shift in the voltage dependence of activation of Kv4.3 channels and slowed activation kinetics. Similar effects were seen on gating of cloned Kv4.2 channels, but the inhibition was less pronounced and required higher toxin concentrations. These results reveal SNX-482 as the most potent inhibitor of Kv4.3 channels yet identified. Because of the effects on both Kv4.3 and Kv4.2 channels, caution is needed when interpreting the effects of SNX-482 on cells and circuits where these channels are present.
Cav2.3, IA, ICK toxin, Kv4.2, Kv4.3, tarantula toxin
Inhibition of A-Type Potassium Current by the Peptide Toxin SNX-482
Tilia Kimm and Bruce P. Beancorresponding author
2014 Jul 9
ESICM LIVES 2016: part twoMilan, Italy. 1-5 October 2016
2016 Sep 29
ESICM LIVES 2016: part threeMilan, Italy. 1-5 October 2016
2016 Sep 29