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Isoeugenol acetate

$52

  • Brand : BIOFRON

  • Catalogue Number : BD-P0209

  • Specification : 98.0%(GC)

  • CAS number : 93-29-8

  • Formula : C12H14O3

  • Molecular Weight : C12H14O3

  • Volume : 25mg

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Catalogue Number

BD-P0209

Analysis Method

Specification

98.0%(GC)

Storage

-20℃

Molecular Weight

C12H14O3

Appearance

Botanical Source

Structure Type

Simple Phenylpropanoids

Category

SMILES

Synonyms

IUPAC Name

Applications

Density

1.1±0.1 g/cm3

Solubility

Flash Point

113.9±16.4 °C

Boiling Point

283.0±20.0 °C at 760 mmHg

Melting Point

79-81 °C(lit.)

InChl

InChl Key

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:93-29-8) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

18416757

Abstract

Background: Isoeugenol, an important fragrance allergen in consumers, has been restricted to 200 p.p.m. since 1998 according to guidelines issued by the fragrance industry. However, no decline in contact allergy to isoeugnol has been detected. It has been speculated that isoeugenol derivatives, especially isoeugenyl acetate, are used instead. Isoeugenyl acetate is probably metabolized in the skin to isoeugenol and gives positive patch test reactions in 1/3 of isoeugenol-sensitized individuals.

Objectives: To investigate the content of isoeugenol, isoeugenyl acetate, and two isoeugenol ethers in perfumes/aftershaves.

Materials and methods: 29 international brand perfumes/aftershaves were analysed for the target fragrance ingredient by gas chromatography-mass spectrometry. All samples were analysed in duplicate at detection levels of 1-5 p.p.m.

Results: 16 products (55%) contained isoeugenol. The maximum concentration was 202 p.p.m. 10 products (34%) contained isoeugenyl acetate, which in 9 cases occurred together with isoeugenol. The concentrations of isoeugenyl acetate ranged from 20 to 4689 p.p.m. 13 products (44%) contained 64.9-1755.0 p.p.m. isoeugenyl methyl ether. Isoeugenyl benzyl ether was not detected in any of the investigated products.

Conclusions: Isoeugenyl acetate is present in perfumes/aftershaves, in some products in significant amounts. This may lead to elicitation of contact allergy in isoeugenol-sensitized individuals and may contribute to unchanged levels of isoeugenol sensitization.

Title

Significant exposures to isoeugenol derivatives in perfumes

Author

Suresh Chandra Rastogi 1, Jeanne Duus Johansen

Publish date

2008 May;

PMID

15606655

Abstract

A total of 2261 (808 male, 1453 female) consecutive patients attending contact dermatitis clinics were patch tested to isoeugenol and its derivatives listed in the EU Inventory of Fragrance Ingredients. Positive reactions were found to isoeugenol in 40, transisoeugenol in 40, isoeugenyl acetate in 19, isoeugenyl benzoate in 4, isoeugenyl phenylacetate in 16, isoeugenyl methyl ether in 6 and benzyl isoeugenyl ether in 2 patients. There was a concomitant reaction to isoeugenol in 36/40 of those positive to transisoeugenol, 13/19 of those to isoeugenyl acetate, 3/4 of those to isoeugenyl benzoate and 15/16 of those to isoeugenyl phenylacetate but in none of those 6 positive to isoeugenyl methyl ether and in neither of those 2 positive to benzyl isoeugenyl ether. Concomitant contact allergy between isoeugenol and its derivatives may occur through chemical cross-reactivity or local skin metabolism of the derivatives. It is more commonly observed with the esters rather than the ethers. Isoeugenyl acetate has been proposed as an alternative to isoeugenol, but there is a high degree of concomitant reactivity with isoeugenol.

Title

Contact allergy to isoeugenol and its derivatives: problems with allergen substitution

Author

S Tanaka 1, C Royds, D Buckley, D A Basketter, A Goossens, M Bruze, C Svedman, T Menne, J D Johansen, I R White, J P McFadden

Publish date

Nov-Dec 2004

PMID

10750869

Title

Fragrance allergen substitution

Author

J Middleton

Publish date

2000 Apr;