6,8-Dimethoxy-2-oxo-2H-chromen-7-yl Beta-D-glucopyranoside/6,8-Dimethoxy-2-oxo-2H-chromen-7-yl β-D-glucopyranoside/2H-1-Benzopyran-2-one, 7-(β-D-glucopyranosyloxy)-6,8-dimethoxy-
Calycanthoside is a natural compound isolated from Angelica tenuissima.
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
675.0±55.0 °C at 760 mmHg
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provides coniferyl ferulate(CAS#:483-91-0) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate
The choice of surgical treatment for hepatocellular carcinoma (HCC) depends on several prognostic variables, among which histological features, like microvascular invasion and tumor grade, are well established. This study aims to identify the tissue miRNAs predictive of recurrence after liver resection in “histologically advanced” HCC. We selected 54 patients: 15 retrospective resected patients without recurrence (group A), 19 retrospective resected patients with HCC recurrence (group B), and 20 prospective patients (group C), with 4 recurrence cases. All selected HCC were “histologically advanced” (high Edmondson grade and/or presence of microvascular invasion). A wide spectrum of miRNAs was studied with TaqMan Human microRNA Arrays; qRT-PCR assays were used to validate results on selected miRNAs; immunohistochemistry for IGF2 was applied to study the mechanism of miR-483-3p. As a result, a significant differential expression between group A and B was found for 255 miRNAs. Among them we selected miR-483-3p and miR-548e (P<0.001). As a single variable (group C), HCC with miR-483-3p downregulation (mean fold increase 0.21) had 44.4% of recurrence cases; HCC with miR-483-3p upregulation (mean fold increase 5.94) showed no recurrence cases (P=0.011). At immunohistochemistry (group C), the HCC with loss of cytoplasmic IGF2 expression showed a down-regulation of miR-483-3p (fold increase 0.57). In conclusion, in patients with “histologically advanced” HCC, the analysis of specific tissue miRNAs (particularly miR-483-3p) could help identify the recurrence risk and choose which treatment algorithm to implement (follow-up, resection or transplantation). This could have an important impact on patient survival and transplantation outcome, improving organ allocation.
hepatocellular carcinoma, IGF2, liver resection, miRNA, tumor recurrence
Tissue miRNA 483-3p expression predicts tumor recurrence after surgical resection in histologically advanced hepatocellular carcinomas
Francesco Vasuri,1 Silvia Fittipaldi,1 Vanessa De Pace,2 Laura Gramantieri,3 Valentina Bertuzzo,2 Matteo Cescon,2 Antonio D. Pinna,2 Michelangelo Fiorentino,1 Antonia D’Errico,1 and Matteo Ravaioli2
2018 Apr 3;
ESICM LIVES 2016: part three Milan, Italy. 1-5 October 2016
2016 Sep 29
ESICM LIVES 2016: part two Milan, Italy. 1-5 October 2016
2016 Sep 29