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Isofuranodiene

$1,120

  • Brand : BIOFRON

  • Catalogue Number : BN-O1646

  • Specification : 98%(HPLC)

  • CAS number : 57566-47-9

  • Formula : C15H20O

  • Molecular Weight : 216.3

  • PUBCHEM ID : 636458

  • Volume : 5mg

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Catalogue Number

BN-O1646

Analysis Method

HPLC,NMR,MS

Specification

98%(HPLC)

Storage

-20℃

Molecular Weight

216.3

Appearance

Oil

Botanical Source

This product is isolated and purified from the herbs of Chloranthus spicatus

Structure Type

Sesquiterpenoids

Category

Standards;Natural Pytochemical;API

SMILES

CC1=CCC2=C(CC(=CCC1)C)OC=C2C

Synonyms

Cyclodeca[b]furan, 4,7,8,11-tetrahydro-3,6,10-trimethyl-, (5Z)-/3,6,10-Trimethyl-4,7,8,11-tetrahydro-cyclodeca[b]furan/Germacra-1(10),4,7,11-tetraene, 8,12-epoxy-, (Z,E)-/Isofuranodiene/(5Z)-3,6,10-Trimethyl-4,7,8,11-tetrahydrocyclodeca[b]furan/Cyclodeca[b]furan, 4,7,8,11-tetrahydro-3,6,10-trimethyl-, (5E,9E)-/Cyclodeca(b)furan, 4,7,8,11-tetrahydro-3,6,10-trimethyl-, (E,E)-/(5E,9E)-3,6,10-Trimethyl-4,7,8,11-tetrahydrocyclodeca[b]furan

IUPAC Name

(5E,9E)-3,6,10-trimethyl-4,7,8,11-tetrahydrocyclodeca[b]furan

Density

0.9±0.1 g/cm3

Solubility

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

Flash Point

137.1±6.1 °C

Boiling Point

309.6±11.0 °C at 760 mmHg

Melting Point

InChl

InChI=1S/C15H20O/c1-11-5-4-6-12(2)9-15-14(8-7-11)13(3)10-16-15/h6-7,10H,4-5,8-9H2,1-3H3/b11-7-,12-6-

InChl Key

VMDXHYHOJPKFEK-ADUATRDFSA-N

WGK Germany

RID/ADR

HS Code Reference

2933990000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:57566-47-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

26304411

Abstract

In the search for neuroactive compounds that mimic the nerve growth factor (NGF) activity for the protection against neurodegenerative diseases, the potential medicinal values of foods and plants attracts intense interest. Isofuranodiene is the major constituent of the essential oil of wild celery (Smyrnium olusatrum L., Apiaceae). The cytotoxic effects of isofuranodiene towards rat neuronal PC-12 pheochromocytoma cells were determined by MTT assay, while the cell differentiation was evaluated with xCELLigence real time cell analysis system (RTCA DP), and the neuritogenic activity was assessed by neurite outgrowth image analysis. Isofuranodiene at concentrations of 25 and 12.5 μM alone, or in combination with 50 nM NGF, showed a marked stimulation of neuritogenesis, but it was more effective at 12.5 μM with or without NGF. The present study reports the first evidence of the neuritogenic effects of isofuranodiene, which appears to be a promising neurotrophic and neuroprotective agent deserving further investigation.

Copyright © 2015 Elsevier Ltd. All rights reserved.

KEYWORDS

Isofuranodiene; Isofuranodiene (PubChem CID: 5317424); Nerve growth factor; Neurite outgrowth image analysis; Neuritogenic activity; PC-12 cells; Smyrnium olusatrum L.; xCELLigence RTCA DP system

Title

Isofuranodiene: A neuritogenic compound isolated from wild celery (Smyrnium olusatrum L., Apiaceae)

Author

Mustafa AM1, Maggi F2, Papa F3, Kaya E4, Dikmen M4, ozturk Y4

Publish date

2016 Feb 1

PMID

26134598

Abstract

The essential oil hydrodistilled from the aerial parts of Smyrnium perfoliatum subsp. perfoliatum growing in central Italy was analysed by GC-MS. The main peak in the gas chromatogram was given by the furanosesquiterpene curzerene which is the Cope rearrangement product of isofuranodiene formed into injector and column during the gas chromatographic run. A truthful quantification of these compounds was achieved by HPLC-DAD analysis which showed that isofuranodiene is the main volatile component (180.0 mg/g eo) of S. perfoliatum subsp. perfoliatum, while curzerene occurs in small amounts (18.1 mg/g eo).

KEYWORDS

GC-MS; HPLC; Smyrnium perfoliatum subsp. perfoliatum; essential oil; isofuranodiene

Title

Isofuranodiene is the main volatile constituent of Smyrnium perfoliatum L. subsp. perfoliatum growing in central Italy

Author

Papa F1, Ricciutelli M2, Cianfaglione K3, Maggi F4

Publish date

2016

PMID

25978596

Abstract

Isofuranodiene is a natural sesquiterpene rich occurring in Smyrnium olusatrum, a forgotten culinary herb which was marginalised after the domestication of the improved form of celery. Our recent data showed that isofuranodiene inhibited the proliferation and induced apoptosis in cancer cells. In this study, we investigated its protective effect on d-galactosamine/lipopolysacchride (GalN/LPS)-induced liver injury in SD rats. Oral administration of isofuranodiene (20 and 50 mg/kg) dramatically inhibited GalN/LPS-induced serum elevation of aspartate aminotransferase, alanine aminotransferase and malondialdehyde levels, and significantly ameliorated liver injury as evidenced by the histological improvement in H&E staining. Furthermore, isofuranodiene treatment significantly inhibited GalN/LPS-induced mRNA expression of IL-1β, IL-6 and inducible nitric oxide synthase in liver tissues. The results from this study showed that isofuranodiene protects GalN/LPS-induced liver injury in SD rats and suggested that it may be a potential functional food ingredient for the prevention and treatment of liver diseases.

KEYWORDS

galactosamine/lipopolysaccharide; hepatoprotective; isofuranodiene; rats

Title

Isofuranodiene, the main volatile constituent of wild celery (Smyrnium olusatrum L.), protects d-galactosamin/lipopolysacchride-induced liver injury in rats.

Author

Li W1, Shi J1, Papa F2, Maggi F3, Chen X1,4.

Publish date

2016


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