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Isogosferol

$1,280

  • Brand : BIOFRON

  • Catalogue Number : BN-O1611

  • Specification : 98%(HPLC)

  • CAS number : 53319-52-1

  • Formula : C16H14O5

  • Molecular Weight : 286.3

  • PUBCHEM ID : 148619

  • Volume : 5mg

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Catalogue Number

BN-O1611

Analysis Method

HPLC,NMR,MS

Specification

98%(HPLC)

Storage

-20℃

Molecular Weight

286.3

Appearance

Powder

Botanical Source

This product is isolated and purified from the roots of Heracleum repula

Structure Type

Coumarins

Category

Standards;Natural Pytochemical;API

SMILES

CC(=C)C(COC1=C2C(=CC3=C1OC=C3)C=CC(=O)O2)O

Synonyms

9-[(2-Hydroxy-3-methyl-3-buten-1-yl)oxy]-7H-furo[3,2-g]chromen-7-one/9-((2-Hydroxy-3-methyl-3-butenyl)oxy)-7H-furo(3,2-g)(1)benzopyran-7-one/rtuprhihxsawdp-uhfffaoysa/7H-Furo[3,2-g][1]benzopyran-7-one, 9-[[(2S)-2-hydroxy-3-methyl-3-buten-1-yl]oxy]-/9-[(2-Hydroxy-3-methylbut-3-en-1-yl)oxy]-7H-furo[3,2-g]chromen-7-one/9-{[(2S)-2-Hydroxy-3-methyl-3-buten-1-yl]oxy}-7H-furo[3,2-g]chromen-7-one/7H-Furo(3,2-g)(1)benzopyran-7-one, 9-((2-hydroxy-3-methyl-3-butenyl)oxy)-/7H-Furo[3,2-g][1]benzopyran-7-one, 9-[(2-hydroxy-3-methyl-3-buten-1-yl)oxy]-

IUPAC Name

9-(2-hydroxy-3-methylbut-3-enoxy)furo[3,2-g]chromen-7-one

Density

1.3±0.1 g/cm3

Solubility

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

Flash Point

255.1±28.7 °C

Boiling Point

498.2±45.0 °C at 760 mmHg

Melting Point

InChl

InChI=1S/C16H14O5/c1-9(2)12(17)8-20-16-14-11(5-6-19-14)7-10-3-4-13(18)21-15(10)16/h3-7,12,17H,1,8H2,2H3

InChl Key

RTUPRHIHXSAWDP-UHFFFAOYSA-N

WGK Germany

RID/ADR

HS Code Reference

2933990000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:53319-52-1) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

2989799

Abstract

We have determined the complete nucleotide sequences of three functionally related nitrogen assimilation regulatory genes from Klebsiella pneumoniae and Rhizobium meliloti. These genes are: 1) The K. pneumoniae general nitrogen assimilation regulatory gene ntrC (formerly called glnG), 2) the K. pneumoniae nif-specific regulatory gene nifA, and 3) an R. meliloti nif-specific regulatory gene that appears to be functionally analogous to the K. pneumoniae nifA gene. In addition to the DNA sequence data, gel-purified K. pneumoniae nifA protein was used to determine the amino acid composition of the nifA protein. The K. pneumoniae ntrC and nifA genes code for proteins of 52,259 and 53,319 d respectively. The R. meliloti nifA gene codes for a 59,968 d protein. A central region within each polypeptide, consisting of approximately 200 amino acids, is between 52% and 58% conserved among the three proteins. Neither the amino termini nor the carboxy termini show any conserved sequences. Together with data that shows that the three regulatory proteins activate promoters that share a common consensus sequence in the -10 (5′-TTGCA-3′) and -23 (5′-CTGG-3′) regions, the sequence data presented here suggest a common evolutionary origin for the three regulatory genes.

Title

Nitrogen fixation specific regulatory genes of Klebsiella pneumoniae and Rhizobium meliloti share homology with the general nitrogen regulatory gene ntrC of K. pneumoniae.

Author

W J Buikema, W W Szeto, P V Lemley, W H Orme-Johnson, and F M Ausubel

Publish date

1985 Jun 25;

PMID

25995914

Abstract

The central imidazole ring of the title compound, C24H20Cl2N2O, is twisted with respect to with the planes of the 2,6-di­chloro­benzene and two phenyl rings, making dihedral angles of 74.06 (18), 28.52 (17) and 67.65 (18)°, respectively. The phenyl ring not adjacent to the N-bonded 2-hy­droxy­propyl group shows the greatest twist, presumably to minimize steric inter­actions. In the crystal, mol­ecules are linked by O—H⋯N and C—H⋯O hydrogen-bond contacts into chains along the a-axis direction. The series of parallel chains form a two-dimensional sheet approximately parallel to the bc diagonal. In addition, C—H⋯π inter­actions are observed between the sheets. The atoms of the 2-hy­droxy­propyl group and the N atom of the 1H-imidazole ring to which it is bonded are disordered over two sets of sites, with an occupancy ratio of 0.722 (5):0.278 (5). The structure was refined as an inversion twin.

KEYWORDS

crystal structure, 1-[2-(2,6-di­chloro­phen­yl)-4,5-diphenyl-1H-imidazol-1-yl]propan-2-ol, imidazole ring, amino alcohol, hydrogen bonding, C—H⋯π inter­actions

Title

Crystal structure of 1-[2-(2,6-di­chloro­phen­yl)-4,5-diphenyl-1H-imidazol-1-yl]propan-2-ol

Author

Mehmet Akkurt,a Jerry P. Jasinski,b Shaaban K. Mohamed,c,d Adel A. Marzouk,e and Mustafa R. Albayatif,*

Publish date

2015 May 1;

PMID

31932577

Abstract

Autoimmune hepatitis (AIH) is a necroinflammatory disease associated with interactive cell populations of the innate and adaptive immune systems. The contribution of conventional dendritic cells (cDCs) to AIH and the underlying mechanism remain poorly understood. The frequency of peripheral mature cDCs increased in AIH patients and was positively correlated with disease severity. In experimental autoimmune hepatitis (EAH), hepatic accumulation of mature cDCs was observed, along with an increase in the periphery. Sequentially, bone marrow-derived dendritic cells (BMDC) from EAH mice exhibit more proinflammatory function than those from control mice. In vitro, ConA treatment promotes the maturation of BMDCs, which are characterized by higher expression of MHC-II, costimulatory molecules and cytokine secretion. ConA also induced the expression of autophagy-related protein and the formation of autophagosomes in DCs. To further investigate whether ConA-induced DC activation is associated with autophagy, we utilized 3-MA and bafilomycin A1 to block autophagy flux and accessed the maturation and function of DCs induced by ConA. 3-MA and bafilomycin A1 inhibited the mature status and proinflammatory cytokine secretion and diminished the proliferation and differentiation of CD4+ T cells when ConA-induced BMDCs cocultured CD4+ T cells. We demonstrated that cDCs contribute to the pathogenesis of AIH through excessive maturation. Aberrant autophagy flux plays a vital role in the immunogenic maturation of cDCs in AIH, and tolerogenic cDCs by inhibition of autophagy flux can be exploited as a new therapeutic approach for AIH.

Subject terms: Phosphorylation, Autoimmune diseases

Title

Critical roles of conventional dendritic cells in autoimmune hepatitis via autophagy regulation

Author

Xiaoli Fan,#1 Ruoting Men,#1 Chen Huang,1 Mengyi Shen,1 Tingting Wang,1 Yasmeen Ghnewa,2 Yun Ma,2 Tinghong Ye,3 and Li Yang1

Publish date

2020 Jan


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