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Isorhamnetin

$113

  • Brand : BIOFRON

  • Catalogue Number : BF-I3009

  • Specification : 98%

  • CAS number : 480-19-3

  • Formula : C16H12O7

  • Molecular Weight : 316.27

  • PUBCHEM ID : 5281654

  • Volume : 25mg

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Catalogue Number

BF-I3009

Analysis Method

HPLC,NMR,MS

Specification

98%

Storage

2-8°C

Molecular Weight

316.27

Appearance

Yellow crystal

Botanical Source

Albizia julibrissin,Nelumbo nucifera,Artemisia annua,Bupleurum chinense,Cuscuta chinensis

Structure Type

Flavonoids

Category

Standards;Natural Pytochemical;API

SMILES

COC1=C(C=CC(=C1)C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O)O

Synonyms

3 4' 5 7-tetrahydroxy-3'-methoxy flavone/3,5,7-Trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4H-1-benzopyran-4-one/isorhamnetine/3,4',5,7-tetrahydroxy-3'-methoxyflavone/3-methylquercetin/3,5,7-Trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4H-chromen-4-one/quercetin-3'-methyl ether/ISOHAMNETIN/3'-O-Methyl Quercetin/Isorhanetin/4H-1-Benzopyran-4-one, 3,5,7-trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-/Isorhamnetin/3'-methylquercetin/iso-rhamnetin/3'-Methoxy-3,4',5,7-tetrahydroxyflavone/Isorhamnetol/3'-methoxykaempferol

IUPAC Name

3,5,7-trihydroxy-2-(4-hydroxy-3-methoxyphenyl)chromen-4-one

Density

1.6±0.1 g/cm3

Solubility

Methanol; DMSO

Flash Point

227.8±23.6 °C

Boiling Point

599.4±50.0 °C at 760 mmHg

Melting Point

307°C

InChl

InChl Key

WGK Germany

RID/ADR

HS Code Reference

2932990000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:480-19-3) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

PMID

28176246

Abstract

Isorhamnetin, a flavonoid compound extracted from the Chinese herb Hippophae rhamnoides L., is well known for its anti-inflammatory, anti-oxidative, anti-adipogenic, anti-proliferative, and anti-tumor activities. However, the role of isorhamnetin in cardiac hypertrophy has not been reported. The aims of the present study were to find whether isorhamnetin could alleviate cardiac hypertrophy and to define the underlying molecular mechanisms. Here, we investigated the effects of isorhamnetin (100 mg/kg/day) on cardiac hypertrophy induced by aortic banding in mice. Cardiac hypertrophy was evaluated by echocardiographic, hemodynamic, pathological, and molecular analyses. Our data demonstrated that isorhamnetin could inhibit cardiac hypertrophy and fibrosis 8 weeks after aortic banding. The results further revealed that the effect of isorhamnetin on cardiac hypertrophy was mediated by blocking the activation of phosphatidylinositol 3-kinase-AKT signaling pathway. In vitro studies performed in neonatal rat cardiomyocytes confirmed that isorhamnetin could attenuate cardiomyocyte hypertrophy induced by angiotensin II, which was associated with phosphatidylinositol 3-kinase-AKT signaling pathway. In conclusion, these data indicate for the first time that isorhamnetin has protective potential for targeting cardiac hypertrophy by blocking the phosphatidylinositol 3-kinase-AKT signaling pathway. Thus, our study suggests that isorhamnetin may represent a potential therapeutic strategy for the treatment of cardiac hypertrophy and heart failure.

KEYWORDS

AKT; Cardiac hypertrophy; Isorhamnetin; PI3K; Pressure overload

Title

Isorhamnetin protects against cardiac hypertrophy through blocking PI3K-AKT pathway.

Author

Gao L1, Yao R1, Liu Y1, Wang Z1, Huang Z1, Du B1, Zhang D1, Wu L1, Xiao L1, Zhang Y2.

Publish date

2017 May

PMID

29684859

Abstract

Isorhamnetin, a flavonoid compound extracted from plants’ fruit or leaves, like sea buckthorn (Hippophae rhamnoides L.), has many biological functions, including anti-tumor, anti-oxidant and anti-inflammatory effect. The present study is in order to explore the hepatoprotective effect of isorhamnetin on concanavalin A (ConA)-induced acute fulminant hepatitis and the underlying mechanism. Mice were injected with ConA (25 mg/kg) to induce acute fulminant hepatitis, three doses of isorhamnetin (10/30/90 mg/kg) was intraperitoneally administrated about 1 h previously. The serum and liver tissues were harvested at 2, 8, and 24 h after ConA injection. The levels of serum liver enzymes and proinflammatory cytokines were significantly reduced in isorhamnetin administration groups. Besides, isorhamnetin improved pathological damage. Furthermore, isorhamnetin affected P38/PPAR-α pathway, and subsequently regulated the expression of apoptosis and autophagy related proteins. The present study investigated that isorhamnetin inhibits apoptosis and autophagy via P38/PPAR-α pathway in mice.
Copyright © 2018 Elsevier Masson SAS. All rights reserved.

KEYWORDS

3-methylquercetin; Apoptosis; Autophagy; Concanavalin A; Hepatitis

Title

Isorhamnetin: A hepatoprotective flavonoid inhibits apoptosis and autophagy via P38/PPAR-α pathway in mice.

Author

Lu X1, Liu T2, Chen K3, Xia Y4, Dai W5, Xu S6, Xu L7, Wang F8, Wu L9, Li J10, Li S11, Wang W12, Yu Q13, Feng J14, Fan X15, Zhou Y16, Niu P17, Guo C18.

Publish date

2018 Jul

PMID

29115489

Abstract

Isorhamnetin, a 3‑O‑methylated metabolite of quercetin, exhibits antioxidant effects. However, to the best of our knowledge, no study to date has focused on the effects of isorhamnetin on retinal pigment epithelium (RPE) cells, and its underlying molecular mechanisms. Therefore, the present study aimed to examine the potential protective effect of isorhamnetin against oxidative stress in human RPE cells. The results demonstrated that pretreatment of RPE cells with isorhamnetin significantly protected cell viability against oxidative stress. In addition, isorhamnetin pretreatment inhibited hydrogen peroxide (H2O2)‑induced reactive oxygen species (ROS) production and caspase‑3 activation in RPE cells. Furthermore, isorhamnetin pretreatment significantly increased the phosphorylation of phosphoinositide 3‑kinase (PI3K) and AKT serine/threonine kinase 1 (Akt) in RPE cells exposed to H2O2, compared with cells treated with H2O2 alone. Taken together, the present results demonstrated that isorhamnetin protected human RPE cells from oxidative stress‑induced cell death, and this effect was associated with activation of the PI3K/Akt signaling pathway. Thus, isorhamnetin may be considered as a potential antioxidant useful for the prevention of age‑related macular degeneration.

Title

Isorhamnetin prevents H2O2‑induced oxidative stress in human retinal pigment epithelial cells.

Author

Wang J1, Gong HM2, Zou HH3, Liang L3, Wu XY1.

Publish date

2018 Jan


Description :

Isorhamnetin is a flavonoid compound extracted from the Chinese herb Hippophae rhamnoides L.. Isorhamnetin suppresses skin cancer through direct inhibition of MEK1 and PI3K.