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Isorhoifolin;Apigenin 7-O-rutinoside

$655

  • Brand : BIOFRON

  • Catalogue Number : AV-B01942

  • Specification : 99%

  • CAS number : 552-57-8

  • Formula : C27H30O14

  • Molecular Weight : 578.5

  • PUBCHEM ID : 9851181

  • Volume : 5mg

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Catalogue Number

AV-B01942

Analysis Method

HPLC,NMR,MS

Specification

99%

Storage

2-8°C

Molecular Weight

578.5

Appearance

Yellow powder

Botanical Source

Structure Type

Flavonoids

Category

Standards;Natural Pytochemical;API

SMILES

CC1C(C(C(C(O1)OCC2C(C(C(C(O2)OC3=CC(=C4C(=C3)OC(=CC4=O)C5=CC=C(C=C5)O)O)O)O)O)O)O)O

Synonyms

5-Hydroxy-2-(4-hydroxyphenyl)-7-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-({[(2S,3S,4S,5S,6R)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}methyl)tetrahydro-2H-pyran-2-yl]oxy}-4H-chromen-4-one/5-Hydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-7-yl-6-O-(6-deoxy-α-D-mannopyranosyl)-β-D-glucopyranoside/6-O-(6-Desoxy-α-D-mannopyranosyl)-β-D-glucopyranoside de 5-hydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-7-yle/APIGENIN-7-O-RUTINOSIDE/5-Hydroxy-2-(4-hydroxyphenyl)-7-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-({[(2S,3S,4S,5S,6R)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}methyl)tetrahydro-2H-pyran-2-yl]oxy}-4H-chromen-4-on/5-Hydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-7-yl 6-O-(6-deoxy-α-D-mannopyranosyl)-β-D-glucopyranoside/Apigenin-7-rutinoside/4H-1-Benzopyran-4-one, 7-[[6-O-(6-deoxy-α-D-mannopyranosyl)-β-D-glucopyranosyl]oxy]-5-hydroxy-2-(4-hydroxyphenyl)-/5-Hydroxy-2-(4-hydroxyphenyl)-7-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-({[(2S,3S,4S,5S,6R)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}methyl)tetrahydro-2H-pyran-2-yl]oxy}-4H-chromen-4-one

IUPAC Name

5-hydroxy-2-(4-hydroxyphenyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxychromen-4-one

Density

1.7±0.1 g/cm3

Solubility

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

Flash Point

304.2±27.8 °C

Boiling Point

912.7±65.0 °C at 760 mmHg

Melting Point

270-275ºC

InChl

InChI=1S/C27H30O14/c1-10-20(31)22(33)24(35)26(38-10)37-9-18-21(32)23(34)25(36)27(41-18)39-13-6-14(29)19-15(30)8-16(40-17(19)7-13)11-2-4-12(28)5-3-11/h2-8,10,18,20-29,31-36H,9H2,1H3

InChl Key

FKIYLTVJPDLUDL-UHFFFAOYSA-N

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:552-57-8) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

27661126

Abstract

Colorectal cancer (CRC) is one of the most common prevalent cancer types worldwide. MicroRNAs (miRNAs or miRs) have been demonstrated to play crucial roles in the development, metastasis and drug resistance of CRC. In the present study, a strikingly elevated expression of miR-552 was determined in CRC tumor tissues and cells by a miRNA profiling analysis. Importantly, the gene of A Disintegrin And Metalloprotease (ADAM) family member 28 (ADAM28) was identified as a target of miR-552, which was further validated in terms of genetic dual luciferase report assay. Furthermore, an inhibition of miR-552 in LOVE and LS174T CRC cells by transducing miR-552 inhibitor (antagomiR-552) with a lentiviral vector exhibited an ability to reduce cell proliferation, migration and clonogenicity. Moreover, both LOVO and LS174T cells stably expressing miR-552 inhibitor displayed a decreased ability to develop tumors in a murine xenograft model in vivo. In contrast, a knockdown of ADAM28 by short hairpin RNA could reverse the antagomiR-552-induced inhibition of metastatic features of CRC cells in vitro. These results suggested that miR-552 is an oncomir able to promote CRC metastasis in part through a mechanism of targeting ADAM28, which may be a novel target for CRC treatment and warrants for further investigation.

KEYWORDS

microRNAs, colorectal cancer, miR-552, antagomir, ADAM28

Title

MicroRNA-552 enhances metastatic capacity of colorectal cancer cells by targeting a disintegrin and metalloprotease 28

Author

Jian Wang,#1,2 Hai Li,#3 Yong Wang,1,2 Libin Wang,2 Xiurui Yan,2 Dong Zhang,3 Xiaoqiang Ma,3 Yong Du,1 Xiaoming Liu,2 and Yinxue Yang1,2,3

Publish date

2016 Oct 25;

PMID

29385532

Abstract

The piggyBac transposase (PB) is distinguished by its activity and utility in genome engineering, especially in humans where it has highly promising therapeutic potential. Little is known, however, about the structure-function relationships of the different domains of PB. Here, we demonstrate in vitro and in vivo that its C-terminal Cysteine-Rich Domain (CRD) is essential for DNA breakage, joining and transposition and that it binds to specific DNA sequences in the left and right transposon ends, and to an additional unexpectedly internal site at the left end. Using NMR, we show that the CRD adopts the specific fold of the cross-brace zinc finger protein family. We determine the interaction interfaces between the CRD and its target, the 5′-TGCGT-3′/3′-ACGCA-5′ motifs found in the left, left internal and right transposon ends, and use NMR results to propose docking models for the complex, which are consistent with our site-directed mutagenesis data. Our results provide support for a model of the PB/DNA interactions in the context of the transpososome, which will be useful for the rational design of PB mutants with increased activity.

Title

Sequence-specific DNA binding activity of the cross-brace zinc finger motif of the piggyBac transposase

Author

Nelly Morellet,1 Xianghong Li,2 Silke A Wieninger,3 Jennifer L Taylor,4 Julien Bischerour,5 Severine Moriau,1 Ewen Lescop,1 Benjamin Bardiaux,3 Nathalie Mathy,5 Nadine Assrir,1 Mireille Betermier,5 Michael Nilges,3 Alison B Hickman,4 Fred Dyda,4 Nancy L Craig,2 and Eric Guittet1

Publish date

2018 Mar 16

Title

ESICM LIVES 2016: part three Milan, Italy. 1-5 October 2016

Author

T. Velasquez,1 G. Mackey,2,3 J. Lusk,2,3 U. G. Kyle,2,3 T. Fontenot,2 P. Marshall,2 L. S. Shekerdemian,2,3 J. A. Coss-Bu,corresponding author2,3 A. Nishigaki,corresponding author4 T. Yatabe,4 T. Tamura,4 K. Yamashita,4 M. Yokoyama,4 J. C. Ruiz-Rodriguez,corresponding author5 B. Encina,5 R. Belmonte,5 I. Troncoso,5 P. Tormos,6 M. Riveiro,7 J. Baena,7 A. Sanchez,5 J. BaNeras,8 J. Cordon,5 N. Duran,9 A. Ruiz,5 J. Caballero,5 X. Nuvials,5 J. Riera,5 J. Serra,5 A. M. F. Rutten,10 S. N. M. van Ieperen,corresponding author10 E. P. H. M. Der Kinderen,10 T. Van Logten,10 L. Kovacikova,corresponding author11 P. Skrak,12 M. Zahorec,13 U. G. Kyle,14,15 A. Akcan-Arikan,14,15,16 J. C. Silva,14,15 G. Mackey,14,15 J. Lusk,14,15 M. Goldsworthy,14,15 L. S. Shekerdemian,14,15 J. A. Coss-Bu,corresponding author14,15 D. Wood,corresponding author17 D. Harrison,18 R. Parslow,19 P. Davis,17 J. Pappachan,20 S. Goodwin,17 P. Ramnarayan,21 S. Chernyshuk,22 H. Yemets,corresponding author22 V. Zhovnir,22 S. M. Pulitano’,23 S. De Rosa,23,24 A. Mancino,23 G. Villa,24,25 F. Tosi,23 P. Franchi,corresponding author23 G. Conti,23 B. Patel,corresponding author26 H. Khine,27 A. Shah,27 D. Sung,27 L. Singer,27 S. Haghbin,corresponding author28 S. Inaloo,29 Z. Serati,29 M. Idei,corresponding author30 T. Nomura,31 N. Yamamoto,30 Y. Sakai,30 T. Yoshida,30 Y. Matsuda,30 Y. Yamaguchi,30 S. Takaki,30 O. Yamaguchi,30 T. Goto,31 N. Longani,corresponding author32 S. Medar,32 I. R. Abdel-Aal,corresponding author33 A. S. El Adawy,34 H. M. E. H. Mohammed,34 A. N. Mohamed,34 S. M. Parry,corresponding author35 L. D. Knight,36 L. Denehy,35 N. De Morton,37 C. E. Baldwin,38,39 D. Sani,40 G. Kayambu,40 V. Z. M. da Silva,41,42 P. Phongpagdi,35 Z. A. Puthucheary,43,44,45 C. L. Granger,35,36 J. E. Rydingsward,corresponding author46 C. M. Horkan,47 K. B. Christopher,48,49 D. McWilliams,corresponding author50 C. Jones,50 E. Reeves,50 G. Atkins,50 C. Snelson,50 L. M. Aitken,corresponding author51,52,53 J. Rattray,54 J. Kenardy,55 A. M. Hull,56 A. Ullman,52 R. Le Brocque,55 M. Mitchell,52,53 C. Davis,53 B. Macfarlane,52,53 J. C. Azevedo,57 L. L. Rocha,57 F. F. M. De Freitas,57 A. M. Cavalheiro,57 N. M. Lucinio,57 M. S. Lobato,corresponding author57 G. Ebeling,corresponding author58 A. Kraegpoeth,58 E. Laerkner,59 I. De Brito-Ashurst,corresponding author60 C. White,61 S. Gregory,corresponding author62 L. G. Forni,61 E. Flowers,corresponding author63 A. Curtis,63 C. A. Wood,63 K. Siu,corresponding author64 K. Venkatesan,65 J. B. H. Muhammad,64 L. Ng,64 E. Seet,65 N. Baptista,66 A. Escoval,67 E. Tomas,corresponding author66 R. Agrawal,corresponding author68 R. Mathew,68 A. Varma,68 E. Dima,corresponding author69 E. Charitidou,70 E. Perivolioti,71 M. Pratikaki,71 C. Vrettou,71 A. Giannopoulos,71 S. Zakynthinos,71 C. Routsi,71 E. Atchade,corresponding author72 S. Houze,72 S. Jean-Baptiste,72 G. Thabut,72 C. Geneve,72 S. Tanaka,72 B. Lortat-Jacob,72 P. Augustin,72 M. Desmard,72 P. Montravers,72 F. J. Gonzalez de Molina,corresponding author73,74 S. Barbadillo,75,76 R. Alejandro,77 F. alvarez-Lerma,78 J. Valles,79 R. M. Catalan,80 E. Palencia,81 A. JareNo,82 R. M. Granada,83 M. L. Ignacio,84 GETGAG Working Group, N. Cui,corresponding author85 D. Liu,85 H. Wang,85 L. Su,85 H. Qiu,86 R. Li,87 K. Jaffal,88 A. Rouze,88 J. Poissy,88 B. Sendid,89 S. Nseir,corresponding author88 E. Paramythiotou,corresponding author90 M. Rizos,90 F. Frantzeskaki,90 A. Antoniadou,90 S. Vourli,90 L. Zerva,90 A. Armaganidis,90 J. Riera,corresponding author91,92,93 J. Gottlieb,94,95 M. Greer,94,95 O. Wiesner,94 M. Martinez,91 M. AcuNa,91 J. Rello,91,93 T. Welte,94,95 E. Atchade,corresponding author96 T. Mignot,96 S. Houze,96 S. Jean-Baptiste,96 G. Thabut,96 B. Lortat-Jacob,96 S. Tanaka,96 P. Augustin,96 M. Desmard,96 P. Montravers,96 S. Soussi,corresponding author97 E. Dudoignon,97 A. Ferry,97 M. Chaussard,97 M. Benyamina,97 A. Alanio,98 S. Touratier,99 M. Chaouat,100 M. Lafaurie,101 M. Mimoun,100 A. Mebazaa,97 M. Legrand,97 M. A. Sheils,corresponding author102 C. Patel,102 L. Mohankumar,103 N. Akhtar,102 S. K. Pacheco Noriega,corresponding author104 N. Navarrete Aldana,104 J. L. avila Leon,104 J. Durand Baquero,104 F. Fernandez Bernal,104 E. Ahmadnia,corresponding author105 J. S. Hadley,105,106 M. Millar,107 D. Hall,105 H. Hewitt,105 H. Yasuda,corresponding author108,109 M. Sanui,110 T. Komuro,111 S. Kawano,111 K. Andoh,111 H. Yamamoto,111 E. Noda,111 J. Hatakeyama,111 N. Saitou,111 H. Okamoto,111 A. Kobayashi,111 T. Takei,111 S. Matsukubo,111 JSEPTIC (Japanese Society of Education for Physicians and Trainees in Intensive Care) Clinical Trial Group, H. B. Rotzel,corresponding author112 A. Serrano Lazaro,112 D. Aguillon Prada,112 M. Rodriguez Gimillo,112 O. Diaz Barinas,112 M. L. Blasco Cortes,112 J. Ferreres Franco,112 J. M. Segura Roca,112 A. Carratala,112 B. Goncalves,corresponding author113 R. Turon,113 A. Mendes,113 F. Miranda,113 P. J. Mata,113 D. Cavalcanti,113 N. Melo,113 P. Lacerda,113 P. Kurtz,113 C. Righy,113 L. E. de la Cruz Rosario,corresponding author114 S. P. Gomez Lesmes,114 J. C. Garcia Romero,115 A. N. Garcia Herrera,114 E. D. Diaz Pertuz,116 M. J. Gomez Sanchez,114 E. Regidor Sanz,114 J. Barado Hualde,114 A. Ansotegui Hernandez,114 J. M. Guergue Irazabal,114 V. Spatenkova,corresponding author117 O. Bradac,118 P. Suchomel,119 T. Urli,120 E. Heusch Lazzeri,121 R. Aspide,corresponding author120 M. Zanello,120,121 L. Perez-Borrero,corresponding author122 J. M. Garcia-Alvarez,122 M. D. Arias-Verdu,123 E. Aguilar-Alonso,124 R. Rivera-Fernandez,122 J. Mora-OrdoNez,123 C. De La Fuente-Martos,124 E. Castillo-Lorente,125 F. Guerrero-Lopez,126 S. P. Gomez Lesmes,corresponding author127 L. E. De la Cruz Rosario,127 E. D. Diaz Pertuz,128 A. Ansotegui Hernandez,127 J. C. Garcia Romero,129 M. J. Gomez Sanchez,127 A. N. Garcia Herrera,127 J. Roldan Ramirez,127 E. Regidor Sanz,127 J. Barado Hualde,127 J. P. Tirapu Leon,127 L. Navarro-Guillamon,corresponding author130 S. Cordovilla-Guardia,130 A. Iglesias-Santiago,130 F. Guerrero-Lopez,130 E. Fernandez-Mondejar,130 A. Vidal,corresponding author131 M. Perez,132 A. Juez,132 N. Arias,131 L. Colino,131 J. L. Perez,131 H. Perez,131 P. Calpe,131 M. A. Alcala,131 D. Robaglia,131 C. Perez,131 S. K. Lan,corresponding author133 M. M. Cunha,corresponding author134 T. Moreira,134 F. Santos,134 E. Lafuente,134 M. J. Fernandes,134 J. G. Silva,134 L. E. de la Cruz Rosario,corresponding author135 S. P. Gomez Lesmes,135 A. N. Garcia Herrera,135 J. C. Garcia Romero,136 E. D. Diaz Pertuz,137 M. J. Gomez Sanchez,135 E. Regidor Sanz,135 J. G. Armando Echeverria,135 A. Ansotegui Hernandez,135 J. Barado Hualde,135 V. Podlepich,corresponding author138 E. Sokolova,138 E. Alexandrova,138 K. Lapteva,138 P. Kurtz,corresponding author139,140 C. Shuinotsuka,141 L. Rabello,141 G. Vianna,141 A. Reis,141 C. Cairus,141 J. Salluh,141 F. Bozza,141 J. C. Barrios Torres,corresponding author142 N. J. Fernandez Araujo,142 P. Garcia-Olivares,142 E. Keough,142 M. Dalorzo,142 L. K. Tang,142 I. De Sousa,142 M. Diaz,142 L. J. Marcos-Zambrano,143 J. E. Guerrero,142 S. E. Zamora Gomez,corresponding author144 G. D. Hernandez Lopez,144 A. I. Vazquez Cuellar,144 O. R. Perez Nieto,144 J. A. Castanon Gonzalez,144 D. Bhasin,corresponding author145 S. Rai,145 H. Singh,145 O. Gupta,145 M. K. Bhattal,145 S. Sampley,145 K. Sekhri,146 R. Nandha,146 F. A. Aliaga,corresponding author147,148 F. Olivares,148 F. Appiani,148 P. Farias,148 F. Alberto,148 A. Hernandez,148 S. Pons,corresponding author149 R. Sonneville,149 L. Bouadma,149 M. Neuville,149 E. Mariotte,149 A. Radjou,149 J. Lebut,149 S. Chemam,149 G. Voiriot,149 M. P. Dilly,150 B. Mourvillier,149 R. Dorent,151 P. Nataf,151 M. Wolff,149 J. F. Timsit,149 O. Ediboglu,corresponding author152 S. Ataman,152 H. Ozkarakas,152 C. Kirakli,152 A. Vakalos,corresponding author153 V. Avramidis,153 O. Obukhova,corresponding author154 I. A. Kurmukov,154 S. Kashiya,154 E. Golovnya,155 V. N. Baikova,155 T. Ageeva,156 T. Haritydi,156 E. V. Kulaga,157 J. J. Rios-Toro,158 L. Perez-Borrero,corresponding author158 E. Aguilar-Alonso,159 M. D. Arias-Verdu,160 J. M. Garcia-Alvarez,158 C. Lopez-Caler,160 C. De La Fuente-Martos,159 S. Rodriguez-Fernandez,158 M. Gomez Sanchez-Orezzoli,158 F. Martin-Gallardo,158 J. Nikhilesh,corresponding author161 V. Joshi,162 E. Villarreal,corresponding author163 J. Ruiz,164 M. Gordon,164 A. Quinza,164 J. Gimenez,164 M. PiNol,164 A. Castellanos,164 P. Ramirez,164 Y. D. Jeon,corresponding author165 W. Y. Jeong,166 M. H. Kim,166 I. Y. Jeong,166,167 M. Y. Ahn,166 J. Y. Ahn,166 S. H. Han,166,167 J. Y. Choi,166,167 Y. G. Song,166,167 J. M. Kim,166,167 N. S. Ku,166,167 H. Shah,corresponding author168 F. Kellner,168 F. Rezai,168 N. Mistry,168 P. Yodice,168 V. Ovnanian,168 K. Fless,168 E. Handler,168 R. Martinez Alejos,corresponding author169 J. D. Marti Romeu,170 D. Gonzalez Anton,169 A. Quinart,169 A. Torres Marti,170 M. Llaurado-Serra,corresponding author171 A. Lobo-Civico,172 A. Ventura-Rosado,173 A. PiNol-Tena,174 M. Pi-Guerrero,175 C. PaNos-Espinosa,176 M. Peralvo-Bernat,177 J. Marine-Vidal,178 R. Gonzalez-Engroba,173 N. Montesinos-Cerro,172 M. Treso-Geira,174 A. Valeiras-Valero,175 L. Martinez-Reyes,176 A. Sandiumenge,178 M. F. Jimenez-Herrera,171 CAPCRI Study, S. Helyar,179 P. Riozzi,corresponding author179 A. Noon,179 G. Hallows,179 H. Cotton,179 J. Keep,179 P. A. Hopkins,179 A. Taggu,corresponding author180 S. Renuka,181 S. Sampath,181 P. J. T. Rood,corresponding author182 T. Frenzel,182 R. Verhage,182 M. Bonn,182 P. Pickkers,182 J. G. van der Hoeven,182 M. van den Boogaard,182 F. Corradi,183 L. Melnyk,corresponding author183 F. Moggia,183 R. Pienovi,183 G. Adriano,183 C. Brusasco,183 L. Mariotti,183 M. Lattuada,183 M. J. Bloomer,corresponding author184,185 M. Coombs,186 K. Ranse,187 R. Endacott,188,189,190 B. Maertens,corresponding author191 K. Blot,191 S. Blot,192 M. P. van Nieuw Amerongen,corresponding author193 E. S. van der Heiden,193 J. W. R. Twisk,194 A. R. J. Girbes,193 J. J. Spijkstra,193 P. Riozzi,corresponding author195 S. Helyar,195 H. Cotton,195 G. Hallows,195 A. Noon,195 C. Bell,196 K. Peters,196 A. Feehan,196 J. Keep,195 P. A. Hopkins,195 K. Churchill,corresponding author197 K. Hawkins,197 R. Brook,197 N. Paver,197 R. Endacott,198,199 N. Maistry,corresponding author200 A. van Wijk,corresponding author201 N. Rouw,201 T. van Galen,202 S. Evelein-Brugman,203 A. Taggu,corresponding author204 B. Krishna,205 S. Sampath,206 A. Putzu,corresponding author207 M. Fang,208,209 M. Boscolo Berto,207 A. Belletti,208 T. Cassina,207 L. Cabrini,208 M. Mistry,corresponding author210 Y. Alhamdi,211 I. Welters,211,212 S. T. Abrams,211 C. H. Toh,211 H. S. Han,corresponding author213 E. M. Gil,214 D. S. Lee,214 C. M. Park,213 S. Winder-Rhodes,corresponding author215 R. Lotay,215 J. Doyle,215 M. W. Ke,216 W. C. Huang,216 C. H. Chiang,corresponding author217 W. T. Hung,216 C. C. Cheng,217 K. C. Lin,216 S. C. Lin,216 K. R. Chiou,217 S. R. Wann,216 C. W. Shu,218 P. L. Kang,217 G. Y. Mar,217 C. P. Liu,217 S. Dubo,219 A. Aquevedo,220 M. Jibaja,221 D. Berrutti,222 C. Labra,223 R. Lagos,223 M. F. Garcia,221 V. Ramirez,221 M. Tobar,221 F. Picoita,221 C. Pelaez,221 D. Carpio,223 L. Alegria,223 C. Hidalgo,224 K. Godoy,224 J. Bakker,223 G. Hernandez,corresponding author223 Y. Sadamoto,corresponding author225 K. Katabami,225 T. Wada,225 Y. Ono,225 K. Maekawa,225 M. Hayakawa,225 A. Sawamura,225 S. Gando,225 H. Marin-Mateos,corresponding author226 J. L. Perez-Vela,226 R. Garcia-Gigorro,226 M. A. Corres Peiretti,226 M. J. Lopez-Gude,226 S. Chacon-Alves,226 E. Renes-CarreNo,226 J. C. Montejo-Gonzalez,226 K. L. Parlevliet,corresponding author227 H. R. W. Touw,228 M. Beerepoot,227 C. Boer,228 P. W. G. Elbers,227 P. R. Tuinman,227 S. A. Abdelmonem,229 T. A. Helmy,229 I. El Sayed,230 S. Ghazal,229 S. H. Akhlagh,231 M. Masjedi,corresponding author231,232 K. Hozhabri,231 E. Kamali,233 I. Z?kova,corresponding author234 B. Paldusova,234 P. Sedlak,234 D. Morman,234 A. M. Youn,corresponding author235 Y. Ohta,corresponding author236 M. Sakuma,237 D. Bates,238 T. Morimoto,237 P. L. Su,corresponding author239 W. Y. Chang,239 W. C. Lin,239 C. W. Chen,239,240 F. Facchin,corresponding author241 F. Zarantonello,241 G. Panciera,241 A. De Cassai,241 A. Venrdramin,241 A. Ballin,241 T. Tonetti,241 P. Persona,242 C. Ori,241 L. Del Sorbo,243 S. Rossi,242 G. Vergani,244 M. Cressoni,244 D. Chiumello,245,246 C. Chiurazzi,corresponding author247 M. Brioni,244 I. Algieri,244 T. Tonetti,248 M. Guanziroli,244 A. Colombo,245 I. Tomic,249 A. Colombo,244 F. Crimella,244 E. Carlesso,244 V. Gasparovic,249 L. Gattinoni,248 A. Serpa Neto,corresponding author250,251 M. Schmidt,252,253 T. Pham,254,255,256 A. Combes,253,257 M. Gama de Abreu,258 P. Pelosi,259 M. J. Schultz,251 for the ReVA Research Network and the PROVE Network Investigators, B. H. Katira,corresponding author260,261,262 D. Engelberts,260 R. E. Giesinger,263 C. Ackerley,264 T. Yoshida,260,261,262 D. Zabini,265 G. Otulakowski,260 M. Post,260 W. M. Kuebler,265,266 P. J. McNamara,263 B. P. Kavanagh,260,261,262 R. Pirracchio,corresponding author267,268 M. Resche Rigon,269 M. Carone,270 S. Chevret,269 D. Annane,271 S. Eladawy,corresponding author272 M. El-Hamamsy,272 N. Bazan,273 M. Elgendy,274 G. De Pascale,corresponding author275 M. S. Vallecoccia,275 S. L. Cutuli,275 V. Di Gravio,275 M. A. Pennisi,275 G. Conti,275 M. Antonelli,275 D. T. Andreis,corresponding author276,277 W. Khaliq,276 M. Singer,276 J. Hartmann,278 S. Harm,corresponding author278 S. Alcantara Carmona,corresponding author279 P. Matia Almudevar,279 A. Naharro Abellan,279 J. Veganzones Ramos,279 L. Perez Perez,279 B. Lobo Valbuena,279 N. Martinez Sanz,279 I. Fernandez Simon,279 M. Arrigo,corresponding author280 E. Feliot,280 N. Deye,280 A. Cariou,281 B. Guidet,282 S. Jaber,283 M. Leone,284 M. Resche-Rigon,285 A. Vieillard Baron,286 M. Legrand,280 E. Gayat,280 A. Mebazaa,280 from the FROG ICU Investigators, M. Balik,corresponding author287 I. Kolnikova,287 M. Maly,287 P. Waldauf,288 G. Tavazzi,289 J. Kristof,287 A. Herpain,corresponding author290,291 F. Su,291 E. Post,291 F. Taccone,290,291 J. L. Vincent,290,291 J. Creteur,290,291 C. Lee,corresponding author292,293 F. Hatib,292 Z. Jian,292 S. Buddi,292 M. Cannesson,294 S. Filekovi?,corresponding author295 M. Turel,296 R. Knafelj,297 V. Gorjup,297 R. Stani?,295 P. Gradi?ek,295 O. Cerovi?,295 T. Mirkovi?,295 M. No?,297 J. Tirkkonen,corresponding author298,299 H. Hellevuo,300 K. T. Olkkola,301 S. Hoppu,299 K. C. Lin,302 W. T. Hung,corresponding author302 C. C. Chiang,303 W. C. Huang,302 W. C. Juan,304 S. C. Lin,302 C. C. Cheng,305 P. H. Lin,304 K. Y. Fong,304 D. S. Hou,304 P. L. Kang,305 S. R. Wann,304 Y. S. Chen,306 G. Y. Mar,305 C. P. Liu,303 M. Paul,corresponding author307 W. Bougouin,307 G. Geri,307 F. Dumas,308 B. Champigneulle,307 S. Legriel,309 J. Charpentier,307 J. P. Mira,307 C. Sandroni,310 A. Cariou,307 J. Zimmerman,corresponding author311 E. Sullivan,311 M. Noursadeghi,312 B. Fox,313 D. Sampson,313 L. McHugh,313 T. Yager,313 S. Cermelli,313 T. Seldon,313 S. Bhide,313 R. A. Brandon,313 R. B. Brandon,313 J. Zwaag,corresponding author314 R. Beunders,314 P. Pickkers,314 M. Kox,314 F. Gul,corresponding author315 M. K. Arslantas,315 D. Genc,316 N. Zibandah,316 L. Topcu,315 T. Akkoc,316 I. Cinel,315 E. Greco,corresponding author317 M. P. Lauretta,317 D. T. Andreis,317 M. Singer,317 I. Palacios Garcia,corresponding author318 M. Cordero,318 A. Diaz Martin,318 T. Aldabo Pallas,318 J. Garnacho Montero,318 J. Revuelto Rey,318 L. Roman Malo,318 A. A. Tanaka Montoya,corresponding author319 A. D. C. Amador Martinez,320 L. Y. Delgado Ayala,320 E. Monares Zepeda,320 J. Franco Granillo,320 J. Aguirre Sanchez,320 G. Camarena Alejo,320 A. Rugerio Cabrera,320 A. Pedraza Montenegro,320 T. Pham,321,322,323 G. Beduneau,corresponding author324,325 F. Schortgen,326 L. Piquilloud,327 E. Zogheib,328,329 M. Jonas,330 F. Grelon,331 I. Runge,332 N. Terzi,333,334 S. Grange,334 G. Barberet,335 P. G. Guitard,336 J. P. Frat,337,338 A. Constan,339 J. M. Chretien,340 J. Mancebo,341 A. Mercat,342 J. C. M. Richard,343 L. Brochard,323 The WIND study group, E. Soilemezi,corresponding author344 E. Koco,344 S. Savvidou,344 C. Nouris,344 D. Matamis,344 Plug Working Group, R. Di Mussi,corresponding author345 S. Spadaro,346 C. A. Volta,346 M. Mariani,345 A. Colaprico,345 C. Antonio,345 F. Bruno,345 S. Grasso,345 A. Rodriguez,corresponding author347,348 I. Martin-Loeches,349 E. Diaz,350 J. R. Masclans,351 F. Gordo,352 J. Sole-Violan,353 M. Bodi,347,348 F. X. Aviles-Jurado,348,354 S. Trefler,347,348 M. Magret,347,348 L. F. Reyes,355 J. Marin-Corral,351 J. C. Yebenes,356 A. Esteban,357 A. Anzueto,355 S. Aliberti,358 M. I. Restrepo,355 GETGAG/SEMICYUC, J. Skytte Larsson,corresponding author359 B. Redfors,360 S. E. Ricksten,359 R. Haines,361 J. Powell-Tuck,361 H. Leonard,361 M. Ostermann,corresponding author361 R. E. Berthelsen,corresponding author362 T. S. Itenov,362 A. Perner,363 J. U. Jensen,364 M. Ibsen,362 A. E. K. Jensen,365 M. H. Bestle,362 T. Bucknall,corresponding author366 J. Dixon,367 F. Boa,368 I. MacPhee,369 B. J. Philips,370 AKI Research Group, St George’s University of London, J. Doyle,corresponding author371 F. Saadat,371 T. Samuels,371 S. Huddart,372 B. McCormick,373 R. DeBrunnar,373 J. Preece,373 M. Swart,374 C. Peden,375 S. Richardson,376 L. Forni,371 P. Kalfon,corresponding author377 K. Baumstarck,378 P. Estagnasie,379 M. A. Geantot,380 A. Berric,381 G. Simon,382 B. Floccard,383 T. Signouret,384 M. Boucekine,378 M. Fromentin,385 M. Nyunga,386 A. Sossou,387 M. Venot,388 R. Robert,389 A. Follin,390 A. Renault,391 M. Garrouste,392 O. Collange,393 Q. Levrat,394 I. Villard,395 D. Thevenin,396 J. Pottecher,397 R. G. Patrigeon,398 N. Revel,399 C. Vigne,400 O. Mimoz,401 P. Auquier,378 IPREA Study Group, S. Pawar,corresponding author402 T. Jacques,403 K. Deshpande,403 R. Pusapati,403 B. Wood,403 R. A. Pulham,corresponding author404 J. Wray,404 K. Brown,404 C. Pierce,405 S. Nadel,406 P. Ramnarayan,407 J. R. Azevedo,corresponding author408 W. S. Montenegro,408 D. P. Rodrigues,409 S. C. Sousa,408 V. F. Araujo,408 A. L. Leitao,408 P. H. Prazeres,408 A. V. Mendonca,408 M. P. Paula,409 A. Das Neves,410 C. I. Loudet,410 M. Busico,411 D. Vazquez,412 D. Villalba,413 A. Lischinsky,414 M. Veronesi,415 M. Emmerich,416 E. Descotte,417 A. Juliarena,418 M. Carboni Bisso,419 M. Grando,420 A. Tapia,421 M. Camargo,422 D. Villani Ulla,423 L. Corzo,424 H. Placido dos Santos,425 A. Ramos,426 J. A. Doglia,427 E. Estenssoro,423 M. Carbonara,corresponding author428 S. Magnoni,429 C. L. Mac Donald,430 J. S. Shimony,431 V. Conte,429 F. Triulzi,432 F. Stretti,433 M. Macr?,433 A. Z. Snyder,431 N. Stocchetti,429,433 D. L. Brody,434 V. Podlepich,corresponding author435 V. Shimanskiy,435 I. Savin,435 K. Lapteva,435 A. Chumaev,435 M. C. Tjepkema-Cloostermans,corresponding author436 J. Hofmeijer,437,438 A. Beishuizen,439 H. Hom,439 M. J. Blans,440 M. J. A. M. van Putten,436,438 L. Longhi,corresponding author441 B. Frigeni,442 M. Curinga,443 D. Mingone,444 S. Beretta,445 A. Patruno,446 L. Gandini,446 A. Vargiolu,446 F. Ferri,441 R. Ceriani,441 M. R. Rottoli,442 L. Lorini,441 G. Citerio,444,446 S. Pifferi,corresponding author447 M. Battistini,447 V. Cordolcini,447 A. Agarossi,448 R. Di Rosso,448 F. Ortolano,447 N. Stocchetti,447,448 C. Mora Lourido,449 J. L. Santana Cabrera,449 J. D. Martin Santana,450 L. Melian Alzola,450 C. Garcia del Rosario,449 H. Rodriguez Perez,449 R. Lorenzo Torrent,449 S. Eslami,451,452 A. Dalhuisen,453 T. Fiks,453 M. J. Schultz,454 A. Abu Hanna,451 P. E. Spronk,453,454 M. Wood,455 D. Maslove,456 J. Muscedere,456 S. H. Scott,455 T. Saha,457 A. Hamilton,458 D. Petsikas,458 D. Payne,458 J. G. Boyd,455,459 Z. A. Puthucheary,corresponding author460,461,462 A. S. McNelly,461,463 J. Rawal,463 B. Connolly,464,465 M. J. McPhail,466,467 P. Sidhu,468 A. Rowlerson,469 J. Moxham,470 S. D. Harridge,469 N. Hart,465,470 H. E. Montgomery,461,463 T. Jovaisa,471 B. Thomas,471 D. Gupta,472 D. S. Wijayatilake,471 H. P. Shum,corresponding author473 H. S. King,473 K. C. Chan,474 K. B. Tang,473 W. W. Yan,473 C. Castro Arias,corresponding author475 J. Latorre,475 A. Suarez De La Rica,475 E. Maseda Garrido,475 A. Montero Feijoo,475 C. Hernandez Gancedo,475 A. Lopez TofiNo,475 F. Gilsanz Rodriguez,475 L. K. Gemmell,corresponding author476 R. Campbell,476 P. Doherty,476 A. MacKay,476 N. Singh,corresponding author477 S. Vitaller,corresponding author478 H. Nagib,478 J. Prieto,478 A. Del Arco,478 B. Zayas,478 C. Gomez,478 S. Tirumala,corresponding author479 S. A. Pasha,479 B. K. Kumari,479 P. Martinez-Lopez,corresponding author480 A. Puerto-Morlan,480 P. Nuevo-Ortega,480 L. Martinez Pujol,corresponding author481 R. Algarte Dolset,481 B. Sanchez Gonzalez,481 S. Quintana Riera,481 J. Trenado alvarez,481 S. Quintana,482 L. Martinez,corresponding author482 R. Algarte,482 B. Sanchez,482 J. Trenado,482 E. Tomas,corresponding author483 N. Brock,483 E. Viegas,483 E. Filipe,483 D. Cottle,corresponding author484 T. Traynor,484 M. V. Trasmonte Martinez,corresponding author485 M. Perez Marquez,485,486 L. Colino Gomez,485 N. Arias Martinez,485 J. M. Milicua MuNoz,485,486 B. Quesada Bellver,485,486 M. MuNoz Varea,485 M. a. Alcala Llorente,485 C. Perez Calvo,485 S. D. Hillier,487 M. C. Faulds,corresponding author487 H. Hendra,corresponding author488 N. Lawrence,488 K. Maekawa,corresponding author489 M. Hayakawa,489 Y. Ono,489 A. Kodate,489 Y. Sadamoto,489 N. Tominaga,489 A. Mizugaki,489 H. Murakami,489 T. Yoshida,489 K. Katabami,489 T. Wada,489 A. Sawamura,489 S. Gando,489 S. Silva,corresponding author490,491 L. Kerhuel,492 B. Malagurski,491 G. Citerio,493 R. Chabanne,494 S. Laureys,495 L. Puybasset,496 L. Nobile,corresponding author497 E. R. Pognuz,498 A. O. Rossetti,499 F. Verginella,498 N. Gaspard,500 J. Creteur,497 N. Ben-Hamouda,501 M. Oddo,501 F. S. Taccone,497 Y. Ono,corresponding author502 M. Hayakawa,502 H. Iijima,503 K. Maekawa,502 A. Kodate,502 Y. Sadamoto,502 A. Mizugaki,502 H. Murakami,502 K. Katabami,502 T. Wada,502 A. Sawamura,502 S. Gando,502 A. Kodate,corresponding author504 K. Katabami,504 T. Wada,504 Y. Ono,504 K. Maekawa,504 M. Hayakawa,504 A. Sawamura,504 S. Gando,504 L. W. Andersen,corresponding author505,506 T. Raymond,507 R. Berg,508 V. Nadkarni,508 A. Grossestreuer,509 T. Kurth,510 M. Donnino,506,511 A. Kr?ger,corresponding author512 P. Ostadal,512 M. Janotka,512 D. Vondrakova,512 N. Kongpolprom,corresponding author513,514 J. Cholkraisuwat,514,515 P. T. Pekkarinen,corresponding author516 G. Ristagno,517 S. Masson,517 R. Latini,517 S. Bendel,518 T. Ala-Kokko,519 T. Varpula,516 J. Vaahersalo,516 S. Hoppu,520 M. Tiainen,521 M. M. Mion,522 M. Plebani,522 V. Pettil?,516 M.B. Skrifvars,516 FINNRESUSCI Study Group, Y. Son,corresponding author523 K. S. Kim,523 G. J. Suh,523 W. Y. Kwon,523 J. I. Ko,523 M. J. Park,523 F. Zama Cavicchi,corresponding author524 E. Iesu,524 L. Nobile,524 J. L. Vincent,524 J. Creteur,524 F. S. Taccone,524 H. Tanaka,corresponding author525 N. Otani,526 S. Ode,526 S. Ishimatsu,526 L. Martinez,corresponding author527 R. Algarte,527 B. Sanchez,527 I. Romero,528 F. Martinez,527 S. Quintana,527 J. Trenado,527 D. Vondrakova,corresponding author529 P. Ostadal,529 A. Kruger,529 M. Janotka,529 F. Malek,529 P. Neuzil,529 Y. C. Yeh,corresponding author530 Y. S. Chen,531 C. H. Wang,531 C. H. Huang,530 A. Chao,530 C. T. Lee,530 C. H. Lai,531 W. S. Chan,532 Y. J. Cheng,530 W. Z. Sun,530 S. Kaese,corresponding author533 C. Horstmann,534 P. Lebiedz,534 M. Mourad,535 P. Gaudard,535 J. Eliet,535 N. Zeroual,535 P. Colson,535 P. Ostadal,corresponding author536 M. Mlcek,537 M. Hrachovina,537 A. Kruger,536 D. Vondrakova,536 M. Janotka,536 M. Mates,536 P. Hala,536 O. Kittnar,537 P. Neuzil,536 A. Jacky,corresponding author538 A. Rudiger,539 D. R. Spahn,539 D. A. Bettex,539 A. Kara,corresponding author540 S. Akin,540 D. Dos reis Miranda,540 A. Struijs,540 K. Caliskan,540 R. J. van Thiel,540 E. A. Dubois,540 W. de Wilde,540 F. Zijlstra,540 D. Gommers,540 C. Ince,540 L. Marca,1 A. Xini,541 W. Mongkolpun,corresponding author541 C. P. R. Cordeiro,541 R. T. Leite,541 O. Lheureux,541 A. Bader,541 L. Rincon,541 C. Santacruz,541 J. C. Preiser,541 A. Chao,corresponding author542 A. S. Chao,543 Y. S. Chen,544 W. Kim,corresponding author545 C. Ahn,546 Y. Cho,545 T. H. Lim,546 J. Oh,546 K. S. Choi,547 B. H. Jang,548 J. K. Ha,545 A. Mecklenburg,corresponding author549 J. Stamm,549 G. Soeffker,549 M. Kubik,549 K. Sydow,550 H. Reichenspurner,551 S. Kluge,549 S. Braune,552 B. Bergantino,corresponding author553 F. Ruberto,553 E. Magnanimi,553 E. Privato,553 V. Zullino,553 K. Bruno,553 F. Pugliese,553 G. Sales,corresponding author554 V. Girotto,554 F. Vittone,555 L. Brazzi,554,555 C. Fritz,556,557 A. Kimmoun,corresponding author556,557 F. Vanhuyse,557 B. Trifan,558 S. Orlowski,556 E. Albuisson,559 N. Tran,558 B. Levy,556,557 V. Chhor,corresponding author560 J. Joachim,560 A. Follin,560 B. Champigneulle,560 J. Chatelon,560 G. Fave,560 J. Mantz,560 R. Pirracchio,560 D. Diaz Diaz,corresponding author561 M. Villanova,561 M. Aguirregabyria,561 G. Andrade,561 L. Lopez,561 E. Palencia,561 G. John,corresponding author562 R. Cowan,562 R. Hart,562 K. Lake,562 K. Litchfield,562 J. W. Song,563 Y. J. Lee,563 Y. J. Cho,corresponding author563 S. Choi,563 P. Vermeir,corresponding author564 D. Vandijck,565 S. Blot,566 A. Mariman,567 R. Verhaeghe,565 M. Deveugele,568 D. Vogelaers,569 L. Chok,570 E. B. Bachli,571 D. Bettex,572 S. R. Cottini,573 E. Keller,574 M. Maggiorini,575 R. Schuepbach,corresponding author576 T. Fiks,577 C. Stiphout,577 M. Grevelink,577 I. Vaneker,577 A. Ruijter,578 M. Buise,579 P. E. Spronk,corresponding author577,580 S. Altaba Tena,corresponding author581 L. Galarza Barrachina,581 J. H. Rodriguez Portillo,581 G. Pages Aznar,581 L. Mateu Campos,581 M. D. Ferrandiz Selles,581 M. Arlandis Tomas,581 A. Belenguer Muncharaz,581 L. Skinner,582 S. Monsalvo,583 E. Olavarria,583 R. St?mpfle,corresponding author582 S. J. Na,corresponding author584 J. Park,584 C. R. Chung,584 C. M. Park,584 G. Y. Suh,584 J. H. Yang,584 T. Witter,corresponding author585,586 C. Brousseau,587 M. B. Butler,585 M. Erdogan,588 P. C. Mac Dougall,586 R. S. Green,585,588 T. E. F. Abbott,corresponding author589 H. D. T. Torrance,589 N. Cron,590 N. Vaid,591 J. Emmanuel,592 S. S. Siddiqui,corresponding author593 N. Prabu,593 H. K. Chaudhari,593 V. P. Patil,593 J. V. Divatia,593 S. Solanki,593 A. P. Kulkarni,593 L. A. Rincon Gutierrez,corresponding author594,595 A. Bader,594 A. Brasseur,594 O. Lheureux,594 J. L. Vincent,594 J. Creteur,594 F. S. Taccone,594 D. Hempel,corresponding author596 N. Stauffert,597 F. Recker,598 T. Schr?der,599 S. Reusch,600 J. Schleifer,598 R. Breitkreutz,601 F. Sj?vall,corresponding author602,603 A. Perner,602 M. Hylander Møller,602 R. B. Moraes,corresponding author604,605 F. K. Borges,606 J. A. V. Guillen,606 W. J. C. Zabaletta,606 PICS- HCPA: Programa Intrahospitalar de Combate ? Sepse do Hospital de Clinicas de Porto Alegre, J. Ruiz-Ramos,607 P. Ramirez,corresponding author607 M. R. Marques-MiNana,608 E. Villarreal,607 M. Gordon,607 M. Sosa,607 P. Concha,607 A. Castellanos,607 R. Menendez,609 C. Sanchez Ramirez,corresponding author610 M. Cabrera Santana,610 L. Caipe Balcazar,610 S. Hipola Escalada,610 M. A. Hernandez Viera,610 C. F. L?bbe Vazquez,610 J. J. Diaz Diaz,610 F. Artiles Campelo,611 N. Sangil Monroy,612 P. Saavedra Santana,613 S. Ruiz Santana,610 A. Gutierrez-Pizarraya,corresponding author614 J. Garnacho-Montero,615 C. Martin,616 K. Baumstarck,617 M. Leone,616 I. Martin-Loeches,618 R. Pirracchio,corresponding author619,620 M. Legrand,621 J. L. Mainardi,622 J. Mantz,623 B. Cholley,624 A. Hubbard,625 P. Ruiz Frontera,corresponding author624 L. M. Claraco Vega,624 P. Ruiz de Gopegui Miguelena,624 M. C. Villuendas Uson,624 A. Rezusta Lopez,625 E. Aurensanz Clemente,626 P. Gutierrez IbaNes,624 A. L. Ruiz Aguilar,624 M. Palomar,corresponding author627 P. Olaechea,628 S. Uriona,629 M. Vallverdu,627 M. Catalan,630 X. Nuvials,627 C. Aragon,631 F. Alvarez Lerma,632 ENVIN-HELICS Study Group, Y. D. Jeon,corresponding author633 W. Y. Jeong,634 M. H. Kim,634 I. Y. Jeong,634,635 M. Y. Ahn,634 J. Y. Ahn,634 S. H. Han,634,635 J. Y. Choi,634,635 Y. G. Song,634,635 J. M. Kim,634,635 N. S. Ku,634,635 G. Li Bassi,corresponding author636 E. Aguilera Xiol,636 T. Senussi,636 F. A. Idone,636 A. Motos,636 C. Chiurazzi,637 C. Travierso,638 L. Fernandez-Barat,636 R. Amaro,636 Y. Hua,636 O. T. Ranzani,636 Q. Bobi,636 M. Rigol,636 A. Torres,636 I. Fuentes Fernandez,corresponding author639 E. Andreu Soler,639 A. Pareja Rodriguez de Vera,640 E. Escudero Pastor,641 V. Hernandis,641 J. Ros Martinez,639 R. Jara Rubio,639 M. Miralbes Torner,corresponding author642 S. Carvalho Brugger,642 A. Aragones Eroles,643 S. Iglesias Moles,642 J. Trujillano Cabello,642 J. A. Schoenenberger,642 X. Nuvials Casals,642 M. Vallverdu Vidal,642 B. Balsera Garrido,642 M. Palomar Martinez,642 L. Mirabella,corresponding author644 A. Cotoia,644 L. Tullo,644 A. Stella,644 F. Di Bello,644 A. Di Gregorio,644 M. Dambrosio,644 G. Cinnella,644 L. E. de la Cruz Rosario,corresponding author645 S. P. Gomez Lesmes,645 J. C. Garcia Romero,646 A. N. Garcia Herrera,645 E. D. Diaz Pertuz,647 M. J. Gomez Sanchez,645 E. Regidor Sanz,645 J. Barado Hualde,645 A. Ansotegui Hernandez,645 J. Roldan Ramirez,645 H. Takahashi,corresponding author648,649 F. Kazutoshi,648 Y. Okada,650 W. Oobayashi,651 T. Naito,648 D. K. Baidya,corresponding author652 S. Maitra,652 R. K. Anand,652 B. R. Ray,652 M. K. Arora,652 C. Ruffini,corresponding author653 L. Rota,653 A. Corona,653 G. Sesana,654 S. Ravasi,654 E. Catena,653 D. N. Naumann,corresponding author655 C. Mellis,656 S. L. Husheer,657 J. Bishop,655 M. J. Midwinter,655 S. Hutchings,656 F. Corradi,corresponding author658 C. Brusasco,658 T. Manca,659 A. Ramelli,659 M. Lattuada,658 F. Nicolini,659 T. Gherli,659 A. Vezzani,659 A. Young,corresponding author660 A. Fernandez Carmona,corresponding author661 A. Iglesias Santiago,661 L. Navarro Guillamon,661 M. J. Garcia Delgado,661 M. Delgado-Amaya,corresponding author662 E. Curiel-Balsera,662 L. Rivera-Romero,662 E. Castillo-Lorente,663 F. Carrero-Gomez,664 E. Aguayo-DeHoyos,665 ARIAM registry of adult cardiac surgery, A. J. Healey,corresponding author666 C. Cameron,666 L.R. Jiao,666 R. St?mpfle,666 A. Perez,corresponding author667 S. Martin,667 O. Lopez del Moral,667 S. Toval,667 J. Rico,667 C. Aldecoa,667 K. Oguzhan,668 O. Demirkiran,corresponding author668 M. Kirman,668 S. Bozbay,668 M. E. Kosuk,668 G. Asyralyyeva,668 M. Dilek,668 M. Duzgun,668 S. Telli,668 M. Aydin,668 F. Yilmazer,668 L. E. Hodgson,corresponding author669,670 B. D. Dimitrov,669 C. Stubbs,671 L. G. Forni,672,673 R. Venn,670 D. Vedage,corresponding author674 S. Shawaf,674 P. Naran,674 N. Sirisena,674 J. Kinnear,674 B. D. Dimitrov,675 L. E. Hodgson,corresponding author675,676 C. Stubbs,677 L. G. Forni,678,679 R. Venn,676 J. Gonzalez LondoNo,corresponding author680 C. Lorencio Cardenas,680 A. Sanchez Gines,680 C. Murcia Gubianas,680 E. Clapes Sanchez,681 J. M. Sirvent,680 V. Panafidina,corresponding author682 I. Shlyk,682 V. Ilyina,683 S. Judickas,684 G. Kezyte,corresponding author685 I. Urbanaviciute,685 M. Serpytis,684 E. Gaizauskas,684 J. Sipylaite,684 C. L. Sprung,corresponding author686 G. Munteanu,686 R. C. Morales,686 H. Kasdan,687 T. Volker,687 A. Reiter,687 Y. Cohen,687 Y. Himmel,687 J. Meissonnier,687 M. E. Banderas-Bravo,688 C. Gomez-Jimenez,corresponding author688 M. V. Garcia-Martinez,688 J. F. Martinez-Carmona,688 J. F. Fernandez-Ortega,688 M. J. O‘Dwyer,corresponding author689 M. Starczewska,690 M. Wilks,691 J. L. Vincent,692 The Rapid Diagnosis of Infections in the Critically Ill Team, M. Torsvik,corresponding author693 L. T. Gustad,694,695 I. L. Bangstad,694 L. J. Vinje,694 J. K. Dam?s,696,697,698 E. Sollig?rd,698,699,700 A. Mehl,693,698,701 M. Tsunoda,corresponding author702 M. Kang,702 M. Saito,702 N. Saito,702 N. Akizuki,702 M. Namiki,702 M. Takeda,702 J. Yuzawa,702 A. Yaguchi,702 Tokyo Womens Medical University, F. Frantzeskaki,corresponding author703 P. Tsirigotis,704 S. Chondropoulos,704 E. Paramythiotou,703 M. Theodorakopoulou,703 M. Stamouli,704 K. Gkirkas,704 I. K. Dimopoulou,705 S. Makiko,corresponding author706 M. Tsunoda,706 M. Kang,706 J. Yuzawa,706 N. Akiduki,706 M. Namiki,706 M. Takeda,706 A. Yaguchi,706 S. Preau,corresponding author707,708 M. Ambler,707 A. Sigurta,707 S. Saeed,707 M. Singer,707 S. Jochmans,corresponding author709,710,711 J. Chelly,709,710 L. V. P. Vong,709 O. Sy,709 J. Serbource-Goguel,709 N. Rolin,709 C. M. Weyer,709 R. I.

Publish date

2016 Sep 29


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