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Isoscopoletin

$161

  • Brand : BIOFRON

  • Catalogue Number : BD-P0611

  • Specification : 98.0%(HPLC)

  • CAS number : 776-86-3

  • Formula : C10H8O4

  • Molecular Weight : 192.17

  • PUBCHEM ID : 69894

  • Volume : 20mg

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Catalogue Number

BD-P0611

Analysis Method

Specification

98.0%(HPLC)

Storage

-20℃

Molecular Weight

192.17

Appearance

Powder

Botanical Source

This product is isolated and purified from the herbs of Paederia scandens (Lour.) Merr

Structure Type

Category

SMILES

COC1=C(C=C2C=CC(=O)OC2=C1)O

Synonyms

2H-1-Benzopyran-2-one, 6-hydroxy-7-methoxy-/7-Methoxyesculetin/iso-Scopoletin/6-Hydroxy-7-methoxy-2H-chromen-2-one/6-hydroxy-7-methoxychromen-2-one/Isoscopoletin

IUPAC Name

Applications

Machilusmarin, a new neuroprotective isocoumarin dimer from the stems of Machilus ichangensis Rehd. et Wils.[Pubmed: 23082968 ]Nat Prod Res. 2013;27(17):1542-7. A new isocoumarin dimer, Machilusmarin (1), was isolated from the stem of Machilus ichangensis Rehd. et Wils., together with two known coumarins, scopoletin (2) and Isoscopoletin (3). METHODS AND RESULTS:The structure of Machilusmarin (1) was elucidated by HRMS and NMR spectrums. Machilusmarin (1) showed significant neuroprotective activity against SH-SY5Y human neuroblastoma cells apoptosis induced by hydrogen peroxide at concentrations ranging from 0.625 to 10.0 μg mL(-1).

Density

1.4±0.1 g/cm3

Solubility

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

Flash Point

172.4±22.2 °C

Boiling Point

413.5±45.0 °C at 760 mmHg

Melting Point

206-208ºC

InChl

InChl Key

SYTYLPHCLSSCOJ-UHFFFAOYSA-N

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:776-86-3) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

16881019

Abstract

The ethyl acetate extract of Artemisia argyi leaves showed substantial inhibition in a cell proliferation assay using human CCRF-CEM leukaemia cells. Bioassay-guided fractionation of the extract led to the isolation of scopoletin and isoscopoletin as the active principles. Their IC50 values were 2.6 and 4.0 microM, respectively. Additionally the two substances were tested against the multidrug resistant subline, CEM/ADR5000 where they both showed IC50 values of 1.6 microM. In contrast to the standard cytostatic drugs doxorubicin, vincristine, and paclitaxel, CEM/ADR5000 cells therefore did not exhibit cross-resistance to scopoletin and isoscopoletin.

Title

Activity-guided isolation of scopoletin and isoscopoletin, the inhibitory active principles towards CCRF-CEM leukaemia cells and multi-drug resistant CEM/ADR5000 cells, from Artemisia argyi.

Author

Adams M1, Efferth T, Bauer R.

Publish date

2006 Jul