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Catalogue Number
BD-P0611
Analysis Method
Specification
98.0%(HPLC)
Storage
-20℃
Molecular Weight
192.17
Appearance
Powder
Botanical Source
This product is isolated and purified from the herbs of Paederia scandens (Lour.) Merr
Structure Type
Category
SMILES
COC1=C(C=C2C=CC(=O)OC2=C1)O
Synonyms
2H-1-Benzopyran-2-one, 6-hydroxy-7-methoxy-/7-Methoxyesculetin/iso-Scopoletin/6-Hydroxy-7-methoxy-2H-chromen-2-one/6-hydroxy-7-methoxychromen-2-one/Isoscopoletin
IUPAC Name
Applications
Machilusmarin, a new neuroprotective isocoumarin dimer from the stems of Machilus ichangensis Rehd. et Wils.[Pubmed: 23082968 ]Nat Prod Res. 2013;27(17):1542-7. A new isocoumarin dimer, Machilusmarin (1), was isolated from the stem of Machilus ichangensis Rehd. et Wils., together with two known coumarins, scopoletin (2) and Isoscopoletin (3). METHODS AND RESULTS:The structure of Machilusmarin (1) was elucidated by HRMS and NMR spectrums. Machilusmarin (1) showed significant neuroprotective activity against SH-SY5Y human neuroblastoma cells apoptosis induced by hydrogen peroxide at concentrations ranging from 0.625 to 10.0 μg mL(-1).
Density
1.4±0.1 g/cm3
Solubility
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Flash Point
172.4±22.2 °C
Boiling Point
413.5±45.0 °C at 760 mmHg
Melting Point
206-208ºC
InChl
InChl Key
SYTYLPHCLSSCOJ-UHFFFAOYSA-N
WGK Germany
RID/ADR
HS Code Reference
Personal Projective Equipment
Correct Usage
For Reference Standard and R&D, Not for Human Use Directly.
Meta Tag
provides coniferyl ferulate(CAS#:776-86-3) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate
No Technical Documents Available For This Product.
16881019
The ethyl acetate extract of Artemisia argyi leaves showed substantial inhibition in a cell proliferation assay using human CCRF-CEM leukaemia cells. Bioassay-guided fractionation of the extract led to the isolation of scopoletin and isoscopoletin as the active principles. Their IC50 values were 2.6 and 4.0 microM, respectively. Additionally the two substances were tested against the multidrug resistant subline, CEM/ADR5000 where they both showed IC50 values of 1.6 microM. In contrast to the standard cytostatic drugs doxorubicin, vincristine, and paclitaxel, CEM/ADR5000 cells therefore did not exhibit cross-resistance to scopoletin and isoscopoletin.
Activity-guided isolation of scopoletin and isoscopoletin, the inhibitory active principles towards CCRF-CEM leukaemia cells and multi-drug resistant CEM/ADR5000 cells, from Artemisia argyi.
Adams M1, Efferth T, Bauer R.
2006 Jul