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Isosinensetin

$236

  • Brand : BIOFRON

  • Catalogue Number : BD-P0636

  • Specification : 98.0%(HPLC)

  • CAS number : 17290-70-9

  • Formula : C20H20O7

  • Molecular Weight : 372.4

  • PUBCHEM ID : 632135

  • Volume : 25mg

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Catalogue Number

BD-P0636

Analysis Method

Specification

98.0%(HPLC)

Storage

-20℃

Molecular Weight

372.4

Appearance

Yellow powder

Botanical Source

This product is isolated and purified from the fruit of Citrus aurantium L.

Structure Type

Category

SMILES

COC1=C(C=C(C=C1)C2=CC(=O)C3=C(O2)C(=C(C=C3OC)OC)OC)OC

Synonyms

2-(3,4-Dimethoxyphenyl)-5,7,8-trimethoxy-4H-chromen-4-one/6-Demethoxynobiletin/5,7,8,3',4'-pentamethoxyflavone/Isosinensetin/3',4',5,7,8-Pentamethoxyflavone/4H-1-Benzopyran-4-one, 2-(3,4-dimethoxyphenyl)-5,7,8-trimethoxy-

IUPAC Name

Applications

Oxidative stress-related lung dysfunction by chromium(VI): alleviation by Citrus aurantium L.[Pubmed: 22972417 ]J Physiol Biochem. 2013 Jun;69(2):239-53. Chromium(VI), a very strong oxidant, causes high cytotoxicity through oxidative stress in tissue systems. METHODS AND RESULTS:Our study investigated the potential ability of ethanolic Citrus aurantium L., family Rutaceae extract, used as a nutritional supplement, to alleviate lung oxidative damage induced by Cr(VI). A high-performance liquid chromatography coupled with a mass spectrometer method was developed to separate and identify flavonoids in C. aurantium L. Six flavonoids were identified, as (1) poncirin, (2) naringin, (3) naringenin, (4) quercetin, (5) Isosinensetin, and (6) tetramethyl-o-isoscutellarein. Adult Wistar rats, used in this study, were divided into six groups of six animals each: group I served as controls which received standard diet, group II received via drinking water K2Cr2O7 alone (700 ppm), groups III and IV were pretreated for 10 days with ethanol extract of C. aurantium L. at doses of 100 and 300 mg/kg body weight/day, respectively, and then K2Cr2O7 was administrated during 3 weeks, and groups V and VI received during 10 days only C. aurantium L. ethanol extract at doses of 100 and 300 mg/kg/day, respectively. Ethanol extract of C. aurantium L. was administered orally. Rats exposed to Cr(VI) showed in lung an increase in malondialdehyde and protein carbonyl levels and a decrease in sulflydryl content, glutathione, nonprotein thiol, and vitamins C and E levels. Decreases in enzyme activities such as in Na(+)K(+) ATPase, catalase, glutathione peroxidase, and superoxide dismutase were noted. CONCLUSIONS:Pretreatment with C. aurantium L. of chromium-treated rats ameliorated all biochemical parameters. Lung histological studies confirmed the biochemical parameters and the beneficial role of C. aurantium L.

Density

1.244±0.06 g/cm3 (20 ºC 760 Torr)

Solubility

Methanol; DMF

Flash Point

248.4±30.2 °C

Boiling Point

565.3±50.0 °C at 760 mmHg

Melting Point

198-199 ºC

InChl

InChl Key

UYCWETIUOAGWIL-UHFFFAOYSA-N

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:17290-70-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

No Article Available.