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Isotschimgin

$980

  • Brand : BIOFRON

  • Catalogue Number : AV-C10443

  • Specification : 98%

  • CAS number : 62356-47-2

  • Formula : C17H22O3

  • Molecular Weight : 274.4

  • PUBCHEM ID : 1798663

  • Volume : 5mg

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Catalogue Number

AV-C10443

Analysis Method

HPLC,NMR,MS

Specification

98%

Storage

2-8°C

Molecular Weight

274.4

Appearance

Powder

Botanical Source

Structure Type

Monoterpenoids

Category

Standards;Natural Pytochemical;API

SMILES

CC1(C2CCC1(C(C2)OC(=O)C3=CC=C(C=C3)O)C)C

Synonyms

1,7,7-Trimethylbicyclo[2.2.1]hept-2-yl 4-hydroxybenzoate/Benzoic acid, 4-hydroxy-, 1,7,7-trimethylbicyclo[2.2.1]hept-2-yl ester

IUPAC Name

[(1S,2S,4S)-1,7,7-trimethyl-2-bicyclo[2.2.1]heptanyl] 4-hydroxybenzoate

Applications

Density

1.2±0.1 g/cm3

Solubility

Farnesoid X receptor; Isotschimgine; Non-alcoholic fatty liver disease; Obesity

Flash Point

153.2±13.2 °C

Boiling Point

381.6±15.0 °C at 760 mmHg

Melting Point

InChl

InChI=1S/C17H22O3/c1-16(2)12-8-9-17(16,3)14(10-12)20-15(19)11-4-6-13(18)7-5-11/h4-7,12,14,18H,8-10H2,1-3H3/t12-,14-,17+/m0/s1

InChl Key

WZBMPPVYPMMRNT-RVSPLBMKSA-N

WGK Germany

RID/ADR

HS Code Reference

2933990000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:62356-47-2) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

31679693

Abstract

Obesity and its associated non-alcoholic fatty liver disease (NAFLD) have become epidemic medical problems worldwide; however, the current available therapeutic options are limited. Farnesoid X receptor (FXR) has recently emerged as an attractive target for obesity treatment. Here we demonstrate that isotschimgine (ITG), a constituent in genus Ferula, as a novel FXR agonist with anti-obesity and anti-hepatic steatosis effects. The results showed that ITG activated the FXR transactivity and bound with the ligand binding dormain (LBD) of FXR with gene reporter assays and AlphaScreen assays. In high-fat diet-induced obese (DIO) mice, ITG lowered body weight and fat mass, improved insulin resistance and hepatic steatosis. Mechanistic studies showed that ITG altered the expression levels of FXR downstream genes, lipid synthesis and energy metabolism genes in the liver of mice. Our findings suggest that ITG is a novel FXR agonist and may be a potential therapeutic choice for obesity associated with NAFLD.

Copyright ? 2019 Elsevier Inc. All rights reserved.

KEYWORDS

Farnesoid X receptor; Isotschimgine; Non-alcoholic fatty liver disease; Obesity

Title

Identification of isotschimgine as a novel farnesoid X receptor agonist with potency for the treatment of obesity in mice.

Author

Li Y1, Chen H1, Ke Z1, Huang J2, Huang L2, Yang B1, Fan S3, Huang C4.

Publish date

2020 Jan 15