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Isovanillic Acid

$78

  • Brand : BIOFRON

  • Catalogue Number : BF-I2005

  • Specification : 98%

  • CAS number : 645-08-9

  • Formula : C8H8O4

  • Molecular Weight : 168.15

  • PUBCHEM ID : 12575

  • Volume : 20mg

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Catalogue Number

BF-I2005

Analysis Method

HPLC,NMR,MS

Specification

98%

Storage

2-8°C

Molecular Weight

168.15

Appearance

Off-White crystalline powder

Botanical Source

herbs of Senecio scandens

Structure Type

Phenolics

Category

Standards;Natural Pytochemical;API

SMILES

COC1=C(C=C(C=C1)C(=O)O)O

Synonyms

sovanillic acid/Benzoic acid, 3-hydroxy-4-methoxy-/p-Anisic acid,3-hydroxy/3-hydroxy-4-methoxy-benzoic acid/isovanilinic acid/3-Hydroxyanisic acid/4-methoxy-protocatechuic acid/3-Hydroxy-4-methoxybenzoic acid/Acide isovanillique/3-hydroxy-4-methoxybenzoate/3-Hydroxy-p-anisic acid

IUPAC Name

3-hydroxy-4-methoxybenzoic acid

Density

1.4±0.1 g/cm3

Solubility

Flash Point

145.2±17.2 °C

Boiling Point

344.3±27.0 °C at 760 mmHg

Melting Point

250-253 °C(lit.)

InChl

InChl Key

WGK Germany

RID/ADR

HS Code Reference

2918990000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:645-08-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

PMID

30183376

Abstract

The gut microbiome supplies essential metabolites such as short-chain fatty acids to skeletal muscle mitochondria, and the composition and activity of the microbiota is in turn affected by muscle fitness. To further our understanding of the complex interactions between the gut microbiome and muscle, we examined the effect of microbiota-derived phenolic metabolites on the ability of human muscle cells to take up and metabolize glucose. As a model, we used the differentiated human skeletal muscle myoblast line, LHCN-M2, which expresses typical muscle phenotypic markers. We initially tested a selected panel of parent phenolic compounds and microbial metabolites, and their respective phenolic conjugates, as found in blood. Several of the tested compounds increased glucose uptake and metabolism, notably in high glucose- and insulin-treated myotubes. One of the most effective was isovanillic acid 3 -O-sulfate (IVAS), a metabolite from the microbiome found in the blood, primarily derived from consumed cyanidin 3 -O-glucoside, a major compound in berry fruits. IVAS stimulated a dose-dependent increase in glucose transport through glucose transporter GLUT4- and PI3K-dependent mechanisms. IVAS also up-regulated GLUT1, GLUT4, and PI3K p85α protein, and increased phosphorylation of Akt. The stimulation of glucose uptake and metabolism by a unique microbiome metabolite provides a novel link among diet, gut microbiota, and skeletal muscle energy source utilization.-Houghton, M. J., Kerimi, A., Mouly, V., Tumova, S., Williamson, G. Gut microbiome catabolites as novel modulators of muscle cell glucose metabolism.

KEYWORDS

berry; flavonoid; insulin; microbiota; phenolic

Title

Gut microbiome catabolites as novel modulators of muscle cell glucose metabolism.

Author

Houghton MJ1, Kerimi A1, Mouly V2, Tumova S1, Williamson G1.

Publish date

2019 Feb;

PMID

28272837

Abstract

This study investigated the effect of antioxidants on lipid stability of frozen-stored meat products. Buckwheat hull extract was used to enrich fried meatballs made from ground pork. During 180-d storage of meat products, lipid oxidation (peroxide and 2-thiobarbituric acid reactive substances [TBARS] value) was periodically monitored. The results were compared with butylated hydroxytoluene (BHT). The addition of antioxidants decreased lipid oxidation in stored meatballs. The highest ability to control peroxide and TBARS values was demonstrated for buckwheat hull extract. Moreover, buckwheat hull extract showed a higher 2,2-diphenyl-1-picrylhydrazyl free radical scavenging activity as well as higher Fe(II) ion chelating ability, as compared with BHT. The total content of phenolic compounds are highly correlated to the individual polyphenols in extract of buckwheat hull, among which the following were assayed: 3,4-dihydroxybenzoic acid, 4-hydroxybenzoic acid, gallic acid, isovanillic acid and p-coumaric acid, and flavonoids: isoorientin, quercetin, quercetin 3-d-glucoside, rutin, and vitexin. These results indicate that plant extracts can be used to prolong shelf life of products by protecting them against lipid oxidation and deterioration of their nutritional quality.

© 2017 Institute of Food Technologists®.

KEYWORDS

antioxidants; buckwheat hull; lipid oxidation; meat

Title

The Effect of Buckwheat Hull Extract on Lipid Oxidation in Frozen-Stored Meat Products.

Author

Hęś M1, Szwengiel A2, Dziedzic K3, Le Thanh-Blicharz J4, Kmiecik D1, Gorecka D1.

Publish date

2017 Apr

PMID

24956816

Abstract

OBJECTIVE:
To study the chemical constituents from the roots of Ilex pubescens.

METHODS:
The 95% ethanol extract of the plant was separated by silica gel, Sephadex LH-20 and preparative HPLC chromatography. The structures were elucidated based on the physiochemical properties and spectroscopic analysis.

RESULTS:
Fifteen compounds were isolated and identified as oleuropein(1), oleoside dimethyl ester(2),8 (Z)-nuezhenide(3),3,4-dicaffeoylquinic acid methyl ester(4),3,4,5-tricaffeoylquinic acid methyl ester (5), isovanillic acid(6), syringic acid(7), 3beta-acetyloleanolic acid (8), 3beta-acetylursolic acid(9), uvaol(10), asiatic acid(11), 2alpha-hydroxyursolic acid(12), oleanolic acid (13), ursolic acid (14), stigmasterol-3-O-beta-D-glucopyranoside (15).

CONCLUSION:
Compounds 2,3,8,9 are obtained from this genus for the first time,compounds 5-7,10-12 are isolated from this plant for the first time.

Title

[Chemical constituents from the roots of Ilex pubescens].

Author

Jiang YP, Li H, Pan XZ, Sun XG, Tang QF, Shao M.

Publish date

2013 Nov


Description :

Isovanillic acid (3-Hydroxy-4-methoxybenzoic acid) is a phenolic acid isolated from isolated from S. frutescens, with Anti-inflammatory activity[1].